Therapeutic Uses
Anti-Diabetic
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
5-[[4-[1,1,2,2-tetradeuterio-2-[(5-hydroxypyridin-2-yl)-methylamino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Refer MSDS for complete information
Useful research chemical for a range of applications
Refund Policy
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5-Hydroxy Rosiglitazone D4 usage and description
5-Hydroxy Rosiglitazone D4 is a synthetic drug that is primarily used in clinical research studies to investigate the pharmacokinetics and metabolic pathways of Rosiglitazone, which is an anti-diabetic medication. This compound is a deuterated derivative of Rosiglitazone, which means that it contains four hydrogen atoms that have been replaced with deuterium atoms. This modification is done to improve the accuracy and sensitivity of analytical methods used for drug analysis.
Chemically, 5-Hydroxy Rosiglitazone D4 is a thiazolidinedione derivative that works by activating peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which is a nuclear receptor that regulates glucose and lipid metabolism. PPAR-gamma activation increases insulin sensitivity and glucose uptake in adipose tissue, skeletal muscle, and liver, resulting in improved glycemic control.
In addition to its use in research studies, 5-Hydroxy Rosiglitazone D4 may have potential therapeutic applications in the treatment of type 2 diabetes mellitus. However, due to the limited clinical data available, its safety and efficacy in humans are not yet established.
Overall, 5-Hydroxy Rosiglitazone D4 is a valuable tool for researchers and scientists who are working to understand the mechanisms of action and metabolism of Rosiglitazone, as well as its potential therapeutic applications in the treatment of diabetes.
