Smiles
ClC1=CC=C2/C(C3=NC=CC=C3CCC2=C1)=C(CC4)\CCN4C(OC([2H])([2H])C([2H])([2H])[2H])=O
Therapeutic Uses
Antihistamine
Storage Condition
Store at refrigerator (2-8°C) for long term storage
IUPAC Name
ethyl-d5 4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidine-1-carboxylate
References
"Bruttmann, G,, et al,: J, Allergy Clin, Immunol,, 83, 411 (1989); Haria, M,, et al,: Drugs, 48, 617 (1994)"
Synonyms
ethyl-d5 4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidine-1-carboxylate
Application Notes
"Labeled Loratadine, intended for use as an internal standard for the quantification of Loratadine by GC- or LC-mass spectrometry."
Hazard Compound
Refer MSDS for accurate information
"Labeled Loratadine, intended for use as an internal standard for the quantification of Loratadine by GC- or LC-mass spectrometry."
Refund Policy
We are committed to offering products of the highest quality in order to meet the needs of our customers, and have elaborate systems in
place to ensure that material specifications, their certification and all handling and storage conditions are communicated at the time of
material handover.
We have invested in the highest quality packaging materials and use international logistics partners to service our customers. While all
possible precautions have been taken to deliver the required product(s), there may be some rare situations when our product does not
meet your requirements. Should that arise, please contact us with your concerns and we will endeavour to address them on a priority
basis. If there is no other option, we will either replace your product(s) or issue a refund or account credit, whichever you prefer.
If there is an issue with one or more of our products, our policy is that it must be reported to us within 45 days of your receiving shipment.
While we will always address product issues after the 45 day return window has passed, we cannot issue a refund or account credit. As
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Loratadine-d5 (Ethyl-d5) usage and description
Loratadine D5 is a deuterated version of the antihistamine drug Loratadine, which is primarily used to treat allergic reactions such as hay fever, hives, and other related conditions. Loratadine D5 is a white crystalline powder that is soluble in water and has a molecular weight of 407.55 g/mol. It is a selective antagonist of the H1 histamine receptor, which means that it binds to the receptor and inhibits the action of histamine, which is responsible for causing allergic reactions.
One of the main advantages of using Loratadine D5 over Loratadine is that it is isotopically labeled with five deuterium atoms, which can be used in pharmacokinetic studies to determine the metabolic fate of the drug in the body. This labeling also allows for more accurate and sensitive detection of the drug in biological samples, which is useful in clinical trials and other research studies.
Loratadine D5 is typically administered orally in the form of tablets or syrup, and the recommended dosage is usually 10 mg once per day. The drug is metabolized in the liver and excreted primarily in the urine, with a half-life of approximately 8-14 hours.
Overall, Loratadine D5 is a useful tool for studying the pharmacokinetics and metabolism of Loratadine, and it offers several advantages over the non-deuterated form of the drug.
