Trabectedin impurity F (14-des hydroxy)

114899-28-4

CS-T-95852

C₃₉H₄₃N₃O₁₀S

745.8

OC1=CC2=C([C@@](C3=O)(CS[C@H]4[C@]([C@@H](C5=C(C=C(C)C(OC)=C5O)C6)N(C)[C@@H]6C7)([H])N7[C@@H](CO3)C8=C9C(OCO9)=C(C)C(OC(C)=O)=C48)NCC2)C=C1OC

Impurity

Trabectedin

Refer MSDS for complete information.

Ecteinascidin 745; (1'R,6R,6aR,7R,13S,16R)- 5-(Acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one

Herrero, A., et al.: Cancer Res., 66, 8155 (2006),

Ecteinascidin 745; (1'R,6R,6aR,7R,13S,16R)- 5-(Acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one

ET-745 is related to Trabectedin (T703500) an alkaloid with antitumor activity isolated from the Caribbean tunicate, Ecteinascidin turbinata.

Refer MSDS for complete information.