CAS No.
[1092578-46-5 (Unlabelled)]
Storage Condition
Refer MSDS for complete information
Synonyms
3-((3R,4S)-4-methyl-3-((methyl-d3)(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Refer MSDS for complete information
(3R,4S)-Tofacitinib-D3 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
We are committed to offering products of the highest quality in order to meet the needs of our customers, and have elaborate systems in
place to ensure that material specifications, their certification and all handling and storage conditions are communicated at the time of
material handover.
We have invested in the highest quality packaging materials and use international logistics partners to service our customers. While all
possible precautions have been taken to deliver the required product(s), there may be some rare situations when our product does not
meet your requirements. Should that arise, please contact us with your concerns and we will endeavour to address them on a priority
basis. If there is no other option, we will either replace your product(s) or issue a refund or account credit, whichever you prefer.
If there is an issue with one or more of our products, our policy is that it must be reported to us within 45 days of your receiving shipment.
While we will always address product issues after the 45 day return window has passed, we cannot issue a refund or account credit. As
always, we appreciate your support.
(3R,4S)-Tofacitinib-D3 usage and description
(3R,4S)-Tofacitinib-D3 is a deuterium-labeled derivative of Tofacitinib, a Janus kinase (JAK) inhibitor used for the treatment of rheumatoid arthritis and psoriatic arthritis. As a JAK inhibitor, (3R,4S)-Tofacitinib-D3 targets the enzymes responsible for the activation of various cytokines, which are involved in the immune response. By inhibiting JAK, (3R,4S)-Tofacitinib-D3 reduces inflammation and immune system activity, leading to the alleviation of symptoms associated with arthritis.
(3R,4S)-Tofacitinib-D3 is typically used in research settings to study the pharmacokinetics and metabolism of Tofacitinib in vivo. The deuterium label allows for the tracking of the drug's distribution and transformation within the body, providing insights into its efficacy and potential side effects. Additionally, (3R,4S)-Tofacitinib-D3 can be used as a reference standard for the development and validation of analytical methods used in the quantification of Tofacitinib in biological matrices.
Chemically, (3R,4S)-Tofacitinib-D3 has a molecular formula of C16H16N6O2S2D3 and a molecular weight of 392.51 g/mol. It is a white to off-white powder with a purity of at least 98% and should be stored at -20°C in a dry and dark place. Its chemical structure contains a pyrrolopyrimidine core with a substituted cyclopentane ring and a sulfonamide group. The deuterium-labeled methyl group is located at the 3-position of the cyclopentane ring.
