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N-​[(S)​-​(4-​Nitrophenoxy)​phenoxy-​2,​3,​4,​5,​6-​d5-​phosphinyl]​-​L-​Alanine-d5 1-​Methylethyl Ester

Chemical Properties and Information

Product Code: CS-T-98958 Stable Isotopes
N-​[(S)​-​(4-​Nitrophenoxy)​phenoxy-​2,​3,​4,​5,​6-​d5-​phosphinyl]​-​L-​Alanine-d5 1-​Methylethyl Ester
API Family
--
Product Code
CS-T-98958

N-​[(S)​-​(4-​Nitrophenoxy)​phenoxy-​2,​3,​4,​5,​6-​d5-​phosphinyl]​-​L-​Alanine-d5 1-​Methylethyl Ester

Stable Isotopes
Stock Status: : Enquire Live

CAT No.
CS-T-98958
CAS No.
1874196-88-9
Molecular Formula
C18H16D5N2O7P
Molecular Weight
413.37
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There is no hazardous surcharge associated with this product.
There is no packaging charge associated with this product.
For Research Purposes only. Not for Personal use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
1874196-88-9
Product Code
CS-T-98958
M.F.
C18H16D5N2O7P
M.W.
413.37
Category
Stable Isotopes
Storage Condition
Refer MSDS for complete information.
IUPAC Name
"N-?[(S)?-?(4-?Nitrophenoxy)?phenoxy-?2,?3,?4,?5,?6-?d5-?phosphinyl]?-?L-?Alanine-d5 1-?Methylethyl Ester"
References
"Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)"
Synonyms
N-​[(S)​-​(4-​Nitrophenoxy)​phenoxy-​2,​3,​4,​5,​6-​d5-​phosphinyl]​-​L-​Alanine-d5 1-​Methylethyl Ester
Application Notes
"N-???[(S)???-???(4-???Nitrophenoxy)???phenoxy-???2,???3,???4,???5,???6-???d5-???phosphinyl]???-???L-???Alanine-d5 1-???Methylethyl Ester is an intermediate in synthesizing PSI-7977-D5 (P839643), an isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-a-fluoro-b-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase."
Hazard Compound
Refer MSDS for complete information.
Overview
"N-???[(S)???-???(4-???Nitrophenoxy)???phenoxy-???2,???3,???4,???5,???6-???d5-???phosphinyl]???-???L-???Alanine-d5 1-???Methylethyl Ester is an intermediate in synthesizing PSI-7977-D5 (P839643), an isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-a-fluoro-b-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase."
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