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For Research Purposes only. Not for Personal use.
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CAS No.
-
Product Code
CS-T-99020
M.F.
C28H23D6ClN4O2
M.W.
495.05
Category
Stable Isotopes
Storage Condition
Refer MSDS for complete information.
IUPAC Name
Bisindolylmaleimide XI Hydrochloride-d6
References
"Wilkinson, S.E. et al.: Biochem. J., 294, 335 (1993); Liu, Q., Chen, X. et al.: . Circ. Res. 105, 194 (2009); Birchall, A.M. et al.: J. Pharmacol. Exp. Ther., 268, 922 (1994)"
Bisindolylmaleimide XI Hydrochloride-d6 is the isotope labelled analog of Bisindolylmaleimide XI Hydrochloride (B448530); a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCa by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic inflammatory responses in vivo.
Hazard Compound
Refer MSDS for complete information.
Overview
Bisindolylmaleimide XI Hydrochloride-d6 is the isotope labelled analog of Bisindolylmaleimide XI Hydrochloride (B448530); a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCa by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic inflammatory responses in vivo.
