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CAS No.
-
Product Code
CS-T-99093
M.F.
C20H11D6FO2S
M.W.
346.45
Category
Stable Isotopes
Storage Condition
Refer MSDS for complete information.
IUPAC Name
Sulindac Sulfide-d6 (Major)
References
"Hermann, C., et al.: Oncogene, 17, 1769 (1998); Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1999); Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (2000);"
"Labelled analogue of Sulindac Sulfide, an active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP."
Hazard Compound
Refer MSDS for complete information.
Overview
"Labelled analogue of Sulindac Sulfide, an active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP."
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