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Ro 106-9920-d5

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Product Code: CS-T-99108 Stable Isotopes Research Use Only
Ro 106-9920-d5
Category
Stable Isotopes
API Family
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Product Code
CS-T-99108
Research Status
For Laboratory Use

Ro 106-9920-d5

Stable Isotopes
Stock Status: : Enquire Live

CAT No.
CS-T-99108
CAS No.
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Molecular Formula
C10H2D5N5OS
Molecular Weight
250.29
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There is no hazardous surcharge associated with this product.
There is no packaging charge associated with this product.
For Research Purposes only. Not for Personal or Veterinary use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
-
Product Code
CS-T-99108
M.F.
C10H2D5N5OS
M.W.
250.29
Category
Stable Isotopes
Storage Condition
Refer MSDS for complete information.
IUPAC Name
Ro 106-9920-d5
References
"Leslie, C., et al.: J. Biol. Chem., 272, 16709 (1997), Liu, F., et al.: Thromb. Res., 106, 199 (2002), Swinney, et al.: J. Biol. Chem., 277, 23573 (2002), Adler, D., et al.: J. Clin. Invest., 118, 2121 (2008),"
Synonyms
"6-[(Phenyl-d5)sulfinyl]tetrazolo[1,5-b]pyridazine;"
Application Notes
"Labelled Ro 106-9920 (R637500). Ro 106-9920 is an inhibitor of NF-?B activation, possibly via selective inhibition of LPS- and TNF-a-induced I?Ba ubiquitination (IC50 = 3 µM). Ro 106-9920 blocks subsequent production of TNF-a, IL-1ß and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS."
Hazard Compound
Refer MSDS for complete information.
Overview
"Labelled Ro 106-9920 (R637500). Ro 106-9920 is an inhibitor of NF-?B activation, possibly via selective inhibition of LPS- and TNF-a-induced I?Ba ubiquitination (IC50 = 3 µM). Ro 106-9920 blocks subsequent production of TNF-a, IL-1ß and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS."

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