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For Research Purposes only. Not for Personal use.
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CAS No.
-
Product Code
CS-T-99108
M.F.
C10H2D5N5OS
M.W.
250.29
Category
Stable Isotopes
Storage Condition
Refer MSDS for complete information.
IUPAC Name
Ro 106-9920-d5
References
"Leslie, C., et al.: J. Biol. Chem., 272, 16709 (1997), Liu, F., et al.: Thromb. Res., 106, 199 (2002), Swinney, et al.: J. Biol. Chem., 277, 23573 (2002), Adler, D., et al.: J. Clin. Invest., 118, 2121 (2008),"
"Labelled Ro 106-9920 (R637500). Ro 106-9920 is an inhibitor of NF-?B activation, possibly via selective inhibition of LPS- and TNF-a-induced I?Ba ubiquitination (IC50 = 3 µM). Ro 106-9920 blocks subsequent production of TNF-a, IL-1ß and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS."
Hazard Compound
Refer MSDS for complete information.
Overview
"Labelled Ro 106-9920 (R637500). Ro 106-9920 is an inhibitor of NF-?B activation, possibly via selective inhibition of LPS- and TNF-a-induced I?Ba ubiquitination (IC50 = 3 µM). Ro 106-9920 blocks subsequent production of TNF-a, IL-1ß and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS."
