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iCRT-14-d5

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Product Code: CS-T-99199 Stable Isotopes Research Use Only
iCRT-14-d5
Category
Stable Isotopes
API Family
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Product Code
CS-T-99199
Research Status
For Laboratory Use

iCRT-14-d5

Stable Isotopes
Stock Status: : Enquire Live

CAT No.
CS-T-99199
CAS No.
1795144-12-5
Molecular Formula
C21H12D5N3O2S
Molecular Weight
380.47
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There is no hazardous surcharge associated with this product.
There is no packaging charge associated with this product.
For Research Purposes only. Not for Personal or Veterinary use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
1795144-12-5
Product Code
CS-T-99199
M.F.
C21H12D5N3O2S
M.W.
380.47
Category
Stable Isotopes
Storage Condition
Refer MSDS for complete information.
IUPAC Name
iCRT-14-d5
References
"Gonsalves, F.C. et al.: Proc. Natl. Acad. Sci. USA, 108, 5954 (2011); Watanabe, K. et al.: Proc. Natl. Acad. Sci. USA, 108, 5929 (2011);"
Synonyms
"5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-(phenyl-d5)-2,4-thiazolidinedione; iCRT 14-d5; iCRT14-d5;"
Application Notes
A labelled potent inhibitor of ß-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between ß-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
Hazard Compound
Refer MSDS for complete information.
Overview
A labelled potent inhibitor of ß-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between ß-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.

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