Therapeutic Uses
Anti-Hypertensives
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
L-Proline, N-[(1S)-1-carboxy-3-(phenyl-d5)propyl]-L-alanyl
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
Refer MSDS for complete information
Enalaprilat-d5 (phenyl-d5) is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Enalaprilat-d5 (phenyl-d5) usage and description
Enalaprilat-d5 (phenyl-d5) is a deuterated form of Enalaprilat, which is a medication used to treat hypertension, heart failure, and diabetic kidney disease. Enalaprilat is a prodrug that is converted to its active form, Enalaprilat, in the liver. Enalaprilat-d5 (phenyl-d5) is chemically identical to Enalaprilat but has five deuterium atoms in the phenyl group, which makes it useful in pharmacokinetic studies and drug metabolism research.
Enalaprilat-d5 (phenyl-d5) can be administered intravenously to patients who cannot take oral medication. The medication works by inhibiting the angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor that raises blood pressure. By inhibiting ACE, Enalaprilat-d5 (phenyl-d5) reduces the levels of angiotensin II, resulting in vasodilation and lowered blood pressure.
Enalaprilat-d5 (phenyl-d5) has a half-life of approximately 1.3 hours and is eliminated primarily through renal excretion. The deuterium labeling on the phenyl group does not affect the pharmacological properties of Enalaprilat-d5 (phenyl-d5), but it does allow for accurate measurements of drug levels in the body and the study of drug metabolism.
Overall, Enalaprilat-d5 (phenyl-d5) is a useful tool in pharmacokinetic and drug metabolism research. Its chemical properties and pharmacological effects make it an effective medication for treating hypertension and heart failure.
