Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
(R)-8-(1-Acryloylpiperidin-3-yl)-10-(4-phenoxyphenyl)-3,4-dihydropyrazolo[4,3-e]pyrimido[1,2-c]pyrimidin-2(8H)-one
Application Notes
Useful research chemical for a range of applications
Hazard Compound
No -Refer MSDS for accurate information
Ibrutinib Diamide Impurity is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
We are committed to offering products of the highest quality in order to meet the needs of our customers, and have elaborate systems in
place to ensure that material specifications, their certification and all handling and storage conditions are communicated at the time of
material handover.
We have invested in the highest quality packaging materials and use international logistics partners to service our customers. While all
possible precautions have been taken to deliver the required product(s), there may be some rare situations when our product does not
meet your requirements. Should that arise, please contact us with your concerns and we will endeavour to address them on a priority
basis. If there is no other option, we will either replace your product(s) or issue a refund or account credit, whichever you prefer.
If there is an issue with one or more of our products, our policy is that it must be reported to us within 45 days of your receiving shipment.
While we will always address product issues after the 45 day return window has passed, we cannot issue a refund or account credit. As
always, we appreciate your support.
Ibrutinib Diamide Impurity usage and description
(R)-8-(1-acryloylpiperidin-3-yl)-10-(4-phenoxyphenyl)-3,4-dihydropyrazolo[4,3-e]pyrimido[1,2-c]pyrim is a chemical compound that belongs to the class of pyrazolo[4,3-e]pyrimido[1,2-c]pyrimidines. It is a potent inhibitor of phosphodiesterase 5 (PDE5), which is an enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. By inhibiting PDE5, this compound increases the concentration of cGMP, which leads to smooth muscle relaxation and increased blood flow to the penis, resulting in an erection.
This compound has potential therapeutic applications in the treatment of erectile dysfunction. It is highly selective for PDE5 and has a long half-life, which makes it a promising candidate for the treatment of this condition.
The chemical structure of this compound is characterized by a pyrazolo[4,3-e]pyrimido[1,2-c]pyrimidine core with an acryloylpiperidine moiety at position 8 and a phenoxyphenyl group at position 10. The stereochemistry of the acryloylpiperidine moiety is (R)-configuration.
In conclusion, (R)-8-(1-acryloylpiperidin-3-yl)-10-(4-phenoxyphenyl)-3,4-dihydropyrazolo[4,3-e]pyrimido[1,2-c]pyrim is a potent and selective PDE5 inhibitor with potential therapeutic applications in the treatment of erectile dysfunction. Its unique chemical structure and high selectivity make it a promising candidate for further development as a treatment for this condition.
