Storage Condition
Refer MSDS for complete information
Synonyms
Ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate;
Ethyl 1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetate
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Yes -Refer MSDS for accurate information
Indomethacin Ethyl Ester is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
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Indomethacin Ethyl Ester usage and description
Indomethacin ethyl ester is a derivative of the anti-inflammatory drug indomethacin. It is commonly used in the treatment of arthritis, gout, and other inflammatory conditions. The ethyl ester form of indomethacin is more lipophilic than the parent compound, which allows for better absorption and distribution throughout the body. Indomethacin ethyl ester is also less irritating to the gastrointestinal tract than indomethacin, making it a more tolerable option for patients.
The chemical structure of indomethacin ethyl ester is similar to that of indomethacin, with the addition of an ethyl group to the carboxylic acid functional group. This modification increases the molecule's stability and enhances its solubility in organic solvents. The ester bond can be hydrolyzed by esterases in the body, releasing the active indomethacin molecule.
Indomethacin ethyl ester works by inhibiting the production of prostaglandins, which are responsible for causing inflammation and pain. It achieves this by blocking the activity of the enzyme cyclooxygenase (COX). COX is responsible for converting arachidonic acid into prostaglandins, so by inhibiting this enzyme, indomethacin ethyl ester reduces the amount of prostaglandins produced.
In conclusion, indomethacin ethyl ester is a useful drug in the treatment of inflammatory conditions. Its chemical properties allow for better absorption and distribution throughout the body, and its mechanism of action involves the inhibition of prostaglandin production through blocking COX activity.
