Therapeutic Uses
Antiretroviral / Anti-HIV
Storage Condition
Store at freezer (-20°C) for long term storage
Synonyms
((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(isopropoxy)phosphoryl)oxy)methyl isopropyl carbonate
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
For long term usage store at -20?C
Hazard Compound
No -Refer MSDS for accurate information
Mono-POC Isopropyl Tenofovir is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
We are committed to offering products of the highest quality in order to meet the needs of our customers, and have elaborate systems in
place to ensure that material specifications, their certification and all handling and storage conditions are communicated at the time of
material handover.
We have invested in the highest quality packaging materials and use international logistics partners to service our customers. While all
possible precautions have been taken to deliver the required product(s), there may be some rare situations when our product does not
meet your requirements. Should that arise, please contact us with your concerns and we will endeavour to address them on a priority
basis. If there is no other option, we will either replace your product(s) or issue a refund or account credit, whichever you prefer.
If there is an issue with one or more of our products, our policy is that it must be reported to us within 45 days of your receiving shipment.
While we will always address product issues after the 45 day return window has passed, we cannot issue a refund or account credit. As
always, we appreciate your support.
Mono-POC Isopropyl Tenofovir usage and description
Mono-POC Isopropyl Tenofovir is a potent nucleotide reverse transcriptase inhibitor that is used for the treatment of HIV-1 infection. It is a prodrug of tenofovir, which is converted into its active form, tenofovir diphosphate, in vivo. Mono-POC Isopropyl Tenofovir is designed to have improved pharmacokinetic properties, which allows for once-daily dosing and better patient compliance.
Chemically, Mono-POC Isopropyl Tenofovir is an ester of isopropyl alcohol and tenofovir. The isopropyl group in the molecule enhances its lipophilicity, which allows for better absorption and distribution in the body. The prodrug is rapidly hydrolyzed by esterases in the blood, releasing tenofovir.
Tenofovir diphosphate inhibits the activity of reverse transcriptase, which is essential for the replication of HIV-1. It competes with the natural substrate, deoxyadenosine triphosphate, and incorporates itself into the growing DNA chain, leading to chain termination. Tenofovir diphosphate also inhibits the activity of viral DNA polymerase, which further reduces viral replication.
Mono-POC Isopropyl Tenofovir is administered orally and is rapidly absorbed from the gastrointestinal tract. It has a long half-life of approximately 17 hours, which allows for once-daily dosing. The drug is primarily eliminated via the kidneys, and dosage adjustments are necessary in patients with renal impairment. Overall, Mono-POC Isopropyl Tenofovir is an effective and well-tolerated treatment for HIV-1 infection.
