Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Propafenone D7 Hydrochloride
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
Refer MSDS for complete information
Propafenone-d7 (Propyl-d7) Hydrochloride is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Propafenone-d7 (Propyl-d7) Hydrochloride usage and description
Propafenone-d7 hydrochloride, also known as propyl-d7 hydrochloride, is a deuterated form of the antiarrhythmic drug propafenone. It is a selective blocker of cardiac sodium channels and also has beta-blocking properties. Propafenone-d7 hydrochloride is used in the treatment of various types of cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia.
Chemically, propafenone-d7 hydrochloride is a substituted arylalkylamine, containing a propyl group. The deuterium atoms in the propyl group are stable isotopes of hydrogen, which are used as tracers in pharmacokinetic studies. Propafenone-d7 hydrochloride is a white crystalline powder that is soluble in water and ethanol.
The pharmacological effects of propafenone-d7 hydrochloride are similar to those of the non-deuterated propafenone. It works by blocking the fast sodium channels in the heart, which slows down the conduction of electrical impulses and helps to restore normal heart rhythm. It also has beta-blocking properties, which reduce the heart rate and the workload on the heart.
Propafenone-d7 hydrochloride is administered orally and is rapidly absorbed from the gastrointestinal tract. It has a half-life of about 6-10 hours and is metabolized in the liver. The drug is excreted mainly in the urine, with a small amount being excreted in the feces. The deuterium-labeled propyl group in propafenone-d7 hydrochloride allows for accurate measurement of its pharmacokinetics, which is useful in drug development and clinical research.
