CAS No.
[36148-89-7 (Unlabelled)]
API Family
Amphotericin B
Storage Condition
Refer MSDS for complete information
Synonyms
(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-methyl 33-(((2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate-13CD3
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Refer MSDS for complete information
Amphotericin B Methyl Ester 13CD3 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Amphotericin B Methyl Ester 13CD3 usage and description
Amphotericin B Methyl Ester 13CD3 is a stable isotope labeled analog of Amphotericin B, a polyene macrolide antifungal antibiotic produced by the soil bacterium Streptomyces nodosus. Amphotericin B Methyl Ester 13CD3 is used as a tracer in pharmacokinetic and metabolic studies to determine the distribution, metabolism, and elimination of Amphotericin B in the body. This stable isotope labeled analog is used in conjunction with mass spectrometry to accurately measure the concentration of Amphotericin B in biological samples.
The chemical formula of Amphotericin B Methyl Ester 13CD3 is C47H73NO13, and its molecular weight is 882.12 g/mol. It is a yellow to orange powder that is soluble in dimethyl sulfoxide, ethanol, and methanol. Amphotericin B Methyl Ester 13CD3 is composed of a macrolide ring structure with two polyene chains containing conjugated double bonds, which are responsible for its antifungal activity.
Amphotericin B Methyl Ester 13CD3 has a similar mechanism of action as Amphotericin B, which is to bind to ergosterol in the fungal cell membrane, disrupting its integrity and leading to cell death. However, the methyl ester modification reduces its antifungal activity and makes it more suitable for use as a tracer in pharmacokinetic studies.
In conclusion, Amphotericin B Methyl Ester 13CD3 is an important tool in pharmacokinetic and metabolic studies of Amphotericin B, providing valuable insights into its distribution, metabolism, and elimination in the body.
