Storage Condition
Refer MSDS for complete information
Synonyms
Apatinib-d8 Hydrochloride, 2468771-44-8
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Refer MSDS for complete information
Apatinib-d8 Hydrochloride is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Apatinib-d8 Hydrochloride usage and description
Apatinib-d8 Hydrochloride is a deuterated form of Apatinib Hydrochloride, which is a potent and selective inhibitor of VEGFR-2. It is an orally administered drug that has been approved for the treatment of advanced gastric cancer and non-small cell lung cancer in China. Apatinib-d8 Hydrochloride is used in medical research to investigate the pharmacokinetics, metabolism, and efficacy of the parent compound.
The chemical formula of Apatinib-d8 Hydrochloride is C25H15D8ClN5O2, and its molecular weight is 469.04 g/mol. It is a white to off-white powder that is soluble in water and organic solvents like DMSO and ethanol. The drug is stable at room temperature and should be stored in a cool, dry place away from light.
Researchers use Apatinib-d8 Hydrochloride in studies that require the use of stable isotope-labeled compounds. The deuterated form of the drug allows for the differentiation of the parent compound from its metabolites in pharmacokinetic studies. It also enables the use of mass spectrometry for quantification and identification of the drug and its metabolites in biological samples.
In conclusion, Apatinib-d8 Hydrochloride is a valuable tool for medical research to investigate the pharmacokinetics and efficacy of Apatinib Hydrochloride. Its stable isotope-labeled form allows for accurate quantification and identification of the drug and its metabolites in biological samples.
