CAS No.
[71963-77-4Unlabeled]
Storage Condition
Keep in a tightly closed vial, store in refrigerator
Synonyms
Artemether 13C D3, 71963-77-4Unlabeled
Application Notes
Useful research chemical for a range of applications
Hazard Compound
No -Refer MSDS for accurate information
Artemether 13C D3 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Artemether 13C D3 usage and description
Artemether 13C D3 is a deuterated form of the antimalarial drug Artemether. It is a synthetic derivative of artemisinin, a plant-based compound extracted from the Chinese herb Artemisia annua. Artemether 13C D3 is used in the treatment of uncomplicated malaria caused by the Plasmodium falciparum parasite, which is responsible for the most severe form of the disease. It is typically administered in combination with other antimalarial drugs, such as lumefantrine.
The deuterium substitution in Artemether 13C D3 allows for more accurate studies of the drug's pharmacokinetics, as it can be easily distinguished from the non-deuterated form in tests and analyses. This information can be used to optimize dosing strategies and improve treatment outcomes.
Artemether 13C D3 is metabolized in the liver by enzymes known as cytochrome P450s, specifically CYP2B6 and CYP3A4. These enzymes convert the drug into its active form, dihydroartemisinin, which acts by targeting and destroying the malaria parasite within the red blood cells.
Overall, Artemether 13C D3 is an important tool in the fight against malaria, providing valuable insights into the pharmacokinetics and metabolism of artemether and helping to improve treatment strategies for this deadly disease.
