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Home Stable Isotopes CS-T-100977

BAY 87-2243-d8

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Product Code: CS-T-100977 Stable Isotopes Research Use Only
BAY 87-2243-d8
Category
Stable Isotopes
API Family
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Product Code
CS-T-100977
Research Status
For Laboratory Use

BAY 87-2243-d8

Stable Isotopes
Stock Status: : Enquire Live

CAT No.
CS-T-100977
CAS No.
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Molecular Formula
C26H18D8F3N7O2
Molecular Weight
533.57
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There is no hazardous surcharge associated with this product.
There is no packaging charge associated with this product.
For Research Purposes only. Not for Personal or Veterinary use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
-
Product Code
CS-T-100977
M.F.
C26H18D8F3N7O2
M.W.
533.57
Category
Stable Isotopes
Storage Condition
Refer MSDS for complete information.
IUPAC Name
BAY 87-2243-d8
References
"Ellinghaus, P., et al.: Cancer Med., 2, 611 (2013)"
Synonyms
"1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]-piperazine-d8"
Application Notes
Isotope labelled BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation. It is found to inhibit HIF-1a and HIF-2a protein accumulation under hypoxic conditions in non-small cell lung cancer cell line H460. It inhibits mitochondrial complex I activity and therefore may be used in antitumor treatment to overcome chemo- and radiotherapy- resistance of hypoxic tumors.
Hazard Compound
Refer MSDS for complete information.
Overview
Isotope labelled BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation. It is found to inhibit HIF-1a and HIF-2a protein accumulation under hypoxic conditions in non-small cell lung cancer cell line H460. It inhibits mitochondrial complex I activity and therefore may be used in antitumor treatment to overcome chemo- and radiotherapy- resistance of hypoxic tumors.

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