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Bisindolylmaleimide XI Hydrochloride-d6

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Product Code: CS-T-99020 Stable Isotopes Research Use Only
Bisindolylmaleimide XI Hydrochloride-d6
Category
Stable Isotopes
API Family
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Product Code
CS-T-99020
Research Status
For Laboratory Use

Bisindolylmaleimide XI Hydrochloride-d6

Stable Isotopes
Stock Status: : Enquire Live

CAT No.
CS-T-99020
CAS No.
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Molecular Formula
C28H23D6ClN4O2
Molecular Weight
495.05
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There is no hazardous surcharge associated with this product.
There is no packaging charge associated with this product.
For Research Purposes only. Not for Personal or Veterinary use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
-
Product Code
CS-T-99020
M.F.
C28H23D6ClN4O2
M.W.
495.05
Category
Stable Isotopes
Storage Condition
Refer MSDS for complete information.
IUPAC Name
Bisindolylmaleimide XI Hydrochloride-d6
References
"Wilkinson, S.E. et al.: Biochem. J., 294, 335 (1993); Liu, Q., Chen, X. et al.: . Circ. Res. 105, 194 (2009); Birchall, A.M. et al.: J. Pharmacol. Exp. Ther., 268, 922 (1994)"
Synonyms
"3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride-d6; Ro 31-0432-d6"
Application Notes
Bisindolylmaleimide XI Hydrochloride-d6 is the isotope labelled analog of Bisindolylmaleimide XI Hydrochloride (B448530); a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCa by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic inflammatory responses in vivo.
Hazard Compound
Refer MSDS for complete information.
Overview
Bisindolylmaleimide XI Hydrochloride-d6 is the isotope labelled analog of Bisindolylmaleimide XI Hydrochloride (B448530); a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCa by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic inflammatory responses in vivo.

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