There is no hazardous surcharge associated with this product.
There is no packaging charge associated with this product.
For Research Purposes only. Not for Personal use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
108605-62-5
Product Code
CS-T-04169
M.F.
C₁₂H₉F₃N₂O₂
M.W.
270.21
Smiles
O=C(/C(C#N)=C(O)\C)NC1=CC=C(C(F)(F)F)C=C1
Category
Impurity
API Family
Leflunomide
Storage Condition
Store at refrigerator (2-8°C) for long term storage
"Kirsch, B,M,, et al,: Arthritis Research and Therapy, 7, 3, R694, (2005)"
Synonyms
Teriflunomide-E Isomer
Application Notes
"rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). "
Purity by HPLC
98.26%
Hazard Compound
Refer MSDS for accurate information.
Overview
"rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). "
