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Stable Isotopes Product Detail
Home Stable Isotopes CS-T-99013

LY 2228820-d9

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Product Code: CS-T-99013 Stable Isotopes Research Use Only
LY 2228820-d9
Category
Stable Isotopes
API Family
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Product Code
CS-T-99013
Research Status
For Laboratory Use

LY 2228820-d9

Stable Isotopes
Stock Status: : Enquire Live

CAT No.
CS-T-99013
CAS No.
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Molecular Formula
C26H28D9FN6O6S2
Molecular Weight
621.79
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There is no hazardous surcharge associated with this product.
There is no packaging charge associated with this product.
For Research Purposes only. Not for Personal or Veterinary use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
-
Product Code
CS-T-99013
M.F.
C26H28D9FN6O6S2
M.W.
621.79
Category
Stable Isotopes
Storage Condition
Refer MSDS for complete information.
IUPAC Name
LY 2228820-d9
References
"Zhao, R. et al.: Drug Metab. Disp., 37, 1251 (2009); Ishitsuka, K. et al.: Br. J. Haematol., 141, 598 (2008); Mader, M. et al.: Bioorg. Med. Chem. Lett., 18, 179 (2008);"
Synonyms
"5-[2-(1,1-Dimethylethyl-d9)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine Dimethanesulfonate;"
Application Notes
"Laballed LY2228820, a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. LY2228820 significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events."
Hazard Compound
Refer MSDS for complete information.
Overview
"Laballed LY2228820, a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. LY2228820 significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events."

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