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For Research Purposes only. Not for Personal use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
80657-57-4
Product Code
CS-DV-03634
M.F.
C5H10O3
M.W.
118.13
Smiles
[C@@H](C(OC)=O)(CO)C
Category
Intermediate
Storage Condition
Refrigerator, under inert atmosphere
IUPAC Name
(S)-3-Hydroxy-2-methylpropionic acid methyl ester
References
Hardcastle, I., et al.: J. Med. Chem., 49, 6209 (2006); Maibaum, J., et al.: J. Med. Chem., 50, 4832 (2007)
Synonyms
methyl 3-hydroxy-2-methylpropanoate
Application Notes
Methyl (S)-(+)-3-Hydroxy-2-methylpropionate is an intermediate used to prepare alkoxy- or alkylamino-substituted isoindolinones as inhibitors of the MDM2-p53 protein-protein interaction. It is also used in the synthesis of aliskiren (46, CGP060536B, SPP100), a highly potent, selective inhibitor of renin used for the treatment of hypertension.
Hazard Compound
Refer MSDS for complete information.
Overview
Methyl (S)-(+)-3-Hydroxy-2-methylpropionate is an intermediate used to prepare alkoxy- or alkylamino-substituted isoindolinones as inhibitors of the MDM2-p53 protein-protein interaction. It is also used in the synthesis of aliskiren (46, CGP060536B, SPP100), a highly potent, selective inhibitor of renin used for the treatment of hypertension.
![Benzyl [2-Amino-2-(hydroxyimino)-1,1-dimethylethyl]carbamate](https://structures.clearsynth.com/Benzyl--2-Amino-2--hydroxyimino--1-1-dimethylethyl-carbamate.png)
