Metabolite Product Detail

N-Desmethyl ponatinib

Name: N-Desmethyl ponatinib
Brand: Clearsynth
SKU: CS-EK-02100
Availability: LimitedAvailability

Explore technical data, documentation access, molecular information and enquiry options for this Clearsynth research product.

Product Code: CS-EK-02100 Metabolite

API Family

Ponatinib

Product Code

CS-EK-02100

N-Desmethyl ponatinib

Ponatinib Metabolite

Stock Status: In Stock
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CAT No.

CS-EK-02100

CAS No.

943319-87-7

Molecular Formula

C₂₈H₂₅F₃N₆O

Molecular Weight

518.53

There is no hazardous surcharge associated with this product.

There is no packaging charge associated with this product.

For Research Purposes only. Not for Personal use.

All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.

CAS No.

943319-87-7

Product Code

CS-EK-02100

M.F.

C₂₈H₂₅F₃N₆O

M.W.

518.53

Smiles

O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCNCC2)C3=CC=C(C(C#CC4=CN=C5C=CC=NN45)=C3)C

Category

Metabolite

API Family

Ponatinib

Storage Condition

Store at refrigerator (2-8°C) for long term storage

IUPAC Name

3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-(1-piperazinylmethyl)-3-(trifluoromethyl)phenyl]-benzamide

References

Kort, A., et al.: Mol. Pharmaceuticals, 14, 3256 (2017);De L., et al.: J. Pharmacol. Exp. Ther., 363, 12-19 (2017); Arts, F. A., et al.: Hum. Mol. Genet., 26, 1801-1810 (2017);

Synonyms

Ponatinib Active Metabolite

Application Notes

Ponatinib Active Metabolite AP24567(M42) is a research reagent applied in pharmaceuticals and cancer treatment. Ponatinib Active Metabolite AP24567(M42) is an analog of Ponatinib (P688250) which is a tyrosine kinase inhibitors (TKI) and used to treat chronic myeloid leukemia (CML) (1,2,3). Ponatinib (P688250) is also used in combination with other drugs, such as forskolin, to combat TKI resistance in patient with CML (3), targeted drug in small-cell lung cancer. Potent FAK inhibitor. FGFR/VEGFR/Bcr-Abl inhibitor It is a COVID19-related research product.

Purity by HPLC

93.78%

Hazard Compound

Refer MSDS for complete information.

Overview

Request Specification Download MSDS TSE / BSE Statement Retest Statement

Refund Policy

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N-Desmethyl ponatinib

N-Desmethyl ponatinib

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N-Desmethyl ponatinib

N-Desmethyl ponatinib

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