Product Detail
N-Desmethyl ponatinib
Ponatinib Metabolite
Stock Status: In Stock
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For Research & Analytical Purposes. Not for Personal use.
Category
Metabolite
API Family
Ponatinib
Storage
Store at refrigerator (2-8°C) for long term storage
Hazard Information
Refer MSDS for complete information.
N-Desmethyl ponatinib Product Information
N-Desmethyl ponatinib is listed under Metabolite. It is associated with Ponatinib and is intended for analytical research, quality control and pharmaceutical reference standard applications. The product is supplied by Clearsynth under CAT No. CS-EK-02100.
Clearsynth provides this compound for research and analytical use, with product information including CAS number, molecular formula, molecular weight, stock enquiry details and supporting documentation.
Technical Data
Product Name
N-Desmethyl ponatinib
CAS No.
943319-87-7
CAT No.
CS-EK-02100
Molecular Formula
C₂₈H₂₅F₃N₆O
Molecular Weight
518.53
Category
API Family
Storage Condition
Store at refrigerator (2-8°C) for long term storage
SMILES
O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCNCC2)C3=CC=C(C(C#CC4=CN=C5C=CC=NN45)=C3)C
IUPAC Name
3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-(1-piperazinylmethyl)-3-(trifluoromethyl)phenyl]-benzamide
Purity by HPLC
93.78%
Hazard Compound
Refer MSDS for complete information.
Description
Overview
Ponatinib Active Metabolite AP24567(M42) is a research reagent applied in pharmaceuticals and cancer treatment. Ponatinib Active Metabolite AP24567(M42) is an analog of Ponatinib (P688250) which is a tyrosine kinase inhibitors (TKI) and used to treat chronic myeloid leukemia (CML) (1,2,3). Ponatinib (P688250) is also used in combination with other drugs, such as forskolin, to combat TKI resistance in patient with CML (3), targeted drug in small-cell lung cancer. Potent FAK inhibitor. FGFR/VEGFR/Bcr-Abl inhibitor It is a COVID19-related research product.
Synonyms
Ponatinib Active Metabolite
Application Notes
Ponatinib Active Metabolite AP24567(M42) is a research reagent applied in pharmaceuticals and cancer treatment. Ponatinib Active Metabolite AP24567(M42) is an analog of Ponatinib (P688250) which is a tyrosine kinase inhibitors (TKI) and used to treat chronic myeloid leukemia (CML) (1,2,3). Ponatinib (P688250) is also used in combination with other drugs, such as forskolin, to combat TKI resistance in patient with CML (3), targeted drug in small-cell lung cancer. Potent FAK inhibitor. FGFR/VEGFR/Bcr-Abl inhibitor It is a COVID19-related research product.
References
Kort, A., et al.: Mol. Pharmaceuticals, 14, 3256 (2017);De L., et al.: J. Pharmacol. Exp. Ther., 363, 12-19 (2017); Arts, F. A., et al.: Hum. Mol. Genet., 26, 1801-1810 (2017);
