Therapeutic Uses
Antibiotics
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Saxagliptin Amide Impurity, 2173146-02-4
Application Notes
Useful research chemical for a range of applications
Hazard Compound
No -Refer MSDS for accurate information
Saxagliptin Amide Impurity is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
We are committed to offering products of the highest quality in order to meet the needs of our customers, and have elaborate systems in
place to ensure that material specifications, their certification and all handling and storage conditions are communicated at the time of
material handover.
We have invested in the highest quality packaging materials and use international logistics partners to service our customers. While all
possible precautions have been taken to deliver the required product(s), there may be some rare situations when our product does not
meet your requirements. Should that arise, please contact us with your concerns and we will endeavour to address them on a priority
basis. If there is no other option, we will either replace your product(s) or issue a refund or account credit, whichever you prefer.
If there is an issue with one or more of our products, our policy is that it must be reported to us within 45 days of your receiving shipment.
While we will always address product issues after the 45 day return window has passed, we cannot issue a refund or account credit. As
always, we appreciate your support.
Saxagliptin Amide Impurity usage and description
Saxagliptin is a popular anti-diabetic drug that is used to control blood sugar levels in patients with type 2 diabetes. The drug works by inhibiting the activity of an enzyme called dipeptidyl peptidase 4 (DPP-4), which is responsible for the breakdown of a hormone called glucagon-like peptide-1 (GLP-1). By inhibiting this enzyme, saxagliptin increases the concentration of GLP-1 in the blood, which in turn stimulates insulin secretion and reduces glucose production in the liver.
However, during the manufacturing process of saxagliptin, an impurity known as saxagliptin amide can be formed. This impurity is a byproduct of the reaction between saxagliptin and an amine compound, which can occur under certain conditions. While saxagliptin amide does not have any therapeutic activity, it is important to monitor its presence in saxagliptin formulations, as it can affect the stability and efficacy of the drug.
Chemically, saxagliptin amide is a derivative of saxagliptin, with the addition of an amide group at the end of the molecule. It has a molecular weight of 404.46 g/mol and a chemical formula of C18H26N4O2. Saxagliptin amide is a white to off-white solid that is soluble in organic solvents such as methanol and acetonitrile, but sparingly soluble in water. Its presence in saxagliptin formulations can be detected and quantified using analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS).