Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
7-Ethyl-10-hydroxycamptothecin-d3
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Refer MSDS for complete information
SN-38-d3 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
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SN-38-d3 usage and description
SN-38-d3 is a deuterium-labeled analogue of SN-38, which is a potent antineoplastic agent used in the treatment of various types of cancer. SN-38-d3 is used in pharmacokinetic studies to study the metabolism and disposition of SN-38 in vivo, as well as to assess the efficacy and safety of chemotherapeutic agents that contain SN-38 as an active ingredient.
SN-38-d3 is a derivative of irinotecan, which is a prodrug that is metabolized to SN-38 in vivo. The deuterium label on SN-38-d3 allows for accurate quantification of the drug in biological samples using mass spectrometry. This is important for determining the pharmacokinetic parameters of SN-38, such as its absorption, distribution, metabolism, and elimination from the body.
The chemical structure of SN-38-d3 is similar to that of SN-38, with the only difference being the presence of deuterium atoms at specific positions in the molecule. SN-38-d3 is a potent inhibitor of topoisomerase I, which is an enzyme involved in DNA replication and repair. By inhibiting topoisomerase I, SN-38-d3 prevents DNA from being properly replicated and repaired, leading to cell death.
In conclusion, SN-38-d3 is a valuable tool for studying the pharmacokinetics and pharmacodynamics of SN-38 and for developing more effective and safer chemotherapeutic agents for cancer treatment.
