Product Detail
Sofosbuvir 3’,5’-Bis-(S)-phosphate
Sofosbuvir Impurity
Stock Status: Enquire
Live
For Research & Analytical Purposes. Not for Personal use.
Category
Impurity
API Family
Sofosbuvir
Storage
Store at refrigerator (2-8°C) for long term storage
Hazard Information
Refer MSDS for accurate information.
Sofosbuvir 3’,5’-Bis-(S)-phosphate Product Information
Sofosbuvir 3’,5’-Bis-(S)-phosphate is listed under Impurity. It is associated with Sofosbuvir and is intended for analytical research, quality control and pharmaceutical reference standard applications. The product is supplied by Clearsynth under CAT No. CS-T-84999.
Clearsynth provides this compound for research and analytical use, with product information including CAS number, molecular formula, molecular weight, stock enquiry details and supporting documentation.
Technical Data
Product Name
Sofosbuvir 3’,5’-Bis-(S)-phosphate
CAS No.
1337482-17-3
CAT No.
CS-T-84999
Molecular Formula
C₃₄H₄₅FN₄O₁₃P₂
Molecular Weight
798.69
Category
API Family
Storage Condition
Store at refrigerator (2-8°C) for long term storage
SMILES
CC(C)OC([C@H](C)NP(O[C@@H]1[C@H](O[C@@H](N2C(NC(C=C2)=O)=O)[C@@]1(F)C)COP(OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O)(OC4=CC=CC=C4)=O)=O
IUPAC Name
isopropyl ((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alaninate
Purity by HPLC
99.77%
Hazard Compound
Refer MSDS for accurate information.
Description
Overview
Sofosbuvir 3',5'-Bis-(S)-phosphate is an impurity of PSI-7977, a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-a-fluoro-ß-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
Synonyms
Sofosbuvir 3',5'-Bis-O-Phosphoramidate
Application Notes
Sofosbuvir 3',5'-Bis-(S)-phosphate is an impurity of PSI-7977, a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-a-fluoro-ß-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
Related Sofosbuvir Products
Sofosbuvir L-alanitate (Mixture of Diasteriomers)
O-Desphenyl Sofosbuvir
Sofosbuvir impurity 32
Sofosbuvir Metabolite GS-566500-13C,d3
Ethyl sofosbuvir
Sofosbuvir metabolite GS-566500
Sofosbuvir metabolite GS331007
Sofosbuvir intermediate isomer Impurity
Sofosbuvir Impurity 22
