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Trans-Abacavir Dihydrochloride

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Product Code: CS-BI-00051 Impurity Research Use Only
Trans-Abacavir Dihydrochloride
Category
Impurity
API Family
Abacavir
Product Code
CS-BI-00051
Research Status
For Laboratory Use

Trans-Abacavir Dihydrochloride

Abacavir Impurity
Stock Status: In Stock
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CAT No.
CS-BI-00051
CAS No.
267668-71-3
Molecular Formula
C14H20Cl2N6O
Molecular Weight
359.25
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There is no hazardous surcharge associated with this product.
There is no packaging charge associated with this product.
For Research Purposes only. Not for Personal or Veterinary use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
267668-71-3
Product Code
CS-BI-00051
M.F.
C14H20Cl2N6O
M.W.
359.25
Smiles
OC[C@H]1C=C[C@H](N2C=NC3=C(NC4CC4)N=C(N)N=C23)C1.[H]Cl.[H]Cl
Category
Impurity
API Family
Abacavir
Storage Condition
Store at refrigerator (2-8°C) for long term storage
IUPAC Name
[(1R,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol;dihydrochloride
References
Synonyms
(1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enylmethanol dihydrochloride
Application Notes
trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir is a carbocyclic 2?-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Purity by HPLC
Not less than 90%
Hazard Compound
Refer MSDS for accurate information.
Overview
trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir is a carbocyclic 2?-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

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