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Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Dioxane, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Dioxane impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Dioxane-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.

Dioxane Related Compounds

Stable Isotopes

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
"2,2,5-Trimethyl-1,3-dioxane-5-carboxylic Acid Vinyl Ester-d... Stable Isotopes CS-T-88091 1185176-80-0 Enquire
"2-tert-Butyl-5-methyl-1,3-dioxane-5-carboxylic Acid Methyl ... Stable Isotopes CS-T-50135 1185175-97-6 Enquire
"2-tert-Butyl-5-methyl-1,3-dioxane-5-carboxylic Acid-d3" Stable Isotopes CS-T-50134 1185147-81-2 Enquire
(6-{2-[3-(4-Phenylcarbamoyl)-5-(4-fluoro-phenyl)-2-isopropyl... Stable Isotopes CS-T-94380 265989-34-2 Enquire
1,3-Dioxane-13C4 Stable Isotopes CS-T-101462 Not Available Enquire
2,2,5-Trimethyl-1,3-dioxane-5-carboxylic Acid Methyl Ester-d... Stable Isotopes CS-T-62458 1189460-82-9 Enquire
2,2,5-Trimethyl-1,3-dioxane-5-carboxylic Acid-d3 Stable Isotopes CS-T-87941 1216916-27-6 Enquire
2,2-Dimethyl-1,3-dioxane-4,6-dione 13C3 Stable Isotopes CS-EK-01215 2033-24-1 unlabeled Enquire
2-tert-Butyl-5-methyl-1,3-dioxane-5-carboxylic Acid Vinyl Es... Stable Isotopes CS-T-94502 1189464-68-3 Enquire
Rapamycin 31,42-Bis(2,2,5-trimethyl-1,3-dioxane-5-carboxylat... Stable Isotopes CS-T-99849 Not Available Enquire


Metabolites

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
2-Ethyl-5,5-dimethyl-1,3-dioxane-d2 Metabolites CS-T-94787 768-58-1 Enquire


Impurities

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
"(3S,6S)-(-)-3,6-Diisopropyl-1,4-dioxane-2,5-dione" Impurities CS-BX-00501 21150-70-9 Enquire
"(3S,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione,homopolymer" Impurities CS-DV-00183 33135-50-1 Enquire
"(4R-cis)-6-Aminomethyl-2,2-dimethyl-1,3-dioxane-4-acetic Ac... Impurities CS-T-47921 853881-01-3 Enquire
"(4S,6S)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic A... Impurities CS-T-51365 196085-85-5 In Stock
"(4S,cis)-1,1-Dimethylethyl-6-aminoethyl-2,2-dimethyl-1,3-di... Impurities CS-T-51150 947586-93-8 Enquire
"1,4-Dioxane-2-carboxylic acid" Impurities CS-M-47435 89364-41-0 Enquire
"2-Isopropyl-1,3-dioxane-5,5-dicarboxylic Acid 5,5-Diethyl E... Impurities CS-T-29901 35113-48-5 Enquire
"2-Isopropyl-5,5-dicarboxy-1,3-dioxane" Impurities CS-T-29900 35113-49-6 Enquire
"2-Methanol-1,4-dioxane " Impurities CS-T-32108 29908-11-0 Enquire
"5-[Bis(methylthio)methylene]-2,2-dimethyl-1,3-dioxane-4,6-d... Impurities CS-T-66945 100981-05-3 Enquire
"Bis(2,5-hydroxymethyl)dioxane" Impurities CS-T-07000 14236-12-5 Enquire
"Bis(2,5-iodomethyl)dioxane" Impurities CS-T-07036 101084-46-2 Enquire
"Bis(2,6-hydroxymethyl)dioxane" Impurities CS-T-07001 54120-69-3 Enquire
(4R,cis)-1,1-Dimethylethyl-6-aminoethyl-2,2-dimethyl-1,3-dio... Impurities CS-T-51151 125995-13-3 In Stock
(4R-CIS)-6-HYDROXYMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETIC A... Impurities CS-O-32239 124655-09-0 Enquire
(4S,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Ac... Impurities CS-T-51366 186508-95-2 Enquire
(4S,6R)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic Ac... Impurities CS-T-56170 148809-28-3 Enquire
(4S,trans)-1,1-Dimethylethyl-6-aminoethyl-2,2-dimethyl-1,3-d... Impurities CS-T-51152 1105067-89-7 Enquire
1,4-BENZODIOXANE-6-BORONIC ACID, PINACOL ESTER Impurities CS-DL-00581 517874-21-4 Enquire
2-(3-Chloropropyl)-2,5,5-trimethyl-1,3-dioxane Impurities CS-MM-09500 Not Available Enquire
2-(4-Fluorophenyl)-5,5-dimethyl-1,3-dioxane-2-butanoic Acid Impurities CS-T-75917 953805-21-5 Enquire
2,2,5-Trimethyl-1,3-dioxane-5-carboxylic Acid Ethenyl Ester Impurities CS-T-45628 865860-80-6 Enquire
3-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carboxamido)propanoic A... Impurities CS-O-51931 135422-90-1 Enquire
5-[1-Hydroxy-2-(2,4,5-trifluoro phenyl)ethylidene]-2,2-dimet... Impurities CS-O-31558 764667-64-3 Enquire
Clascoterone Ethoxy dioxane Impurities CS-O-52444 Not Available Enquire
Ethyl 3-(3-(2,2,5,5-tetramethyl-1,3-dioxane-4-carboxamido)pr... Impurities CS-O-51932 Not Available Enquire
N-Succinimidoxycarbonyl-β-alanine N-Succinimidyl Ester ... Impurities CS-T-61473 1215667-16-5 Enquire
Rapamycin 31,42-Bis(2,2,5-trimethyl-1,3-dioxane-5-carboxylat... Impurities CS-T-85960 1401284-72-7 In Stock


Intermediates

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
"(4R,cis)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetic... Intermediates CS-T-02570 125995-17-7 Enquire
"1,4-Benzodioxane-5-boronic acid" Intermediates CS-AC-05678 499769-88-9 Enquire
"1,4-dioxane-2,5-diol" Intermediates CS-DV-00765 23147-58-2 Enquire
"2-(3-Bromo-4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane" Intermediates CS-T-49830 179942-58-6 Enquire
"2-(Bromomethyl)-1,3-dioxane" Intermediates CS-T-71228 5695-63-6 Enquire
"5-(Aminomethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione" Intermediates CS-M-30992 15568-88-4 Enquire
"5-(Dimethylaminomethylidene)-2,2-dimethyl-1,3-dioxane-4,6-d... Intermediates CS-AC-09116 75039-60-0 Enquire
"5,5-Bis(bromomethyl)-2-phenyl-1,3-dioxane" Intermediates CS-AC-07229 3733-29-7 Enquire
"5-[(1,3-benzodioxol-5-ylamino)methylene]-2,2-dimethyl-1,3-d... Intermediates CS-EL-03977 369398-78-7 Enquire
"5-[(2,5-dimethoxyanilino)methylene]-2,2-dimethyl-1,3-dioxan... Intermediates CS-EL-03945 97545-51-2 Enquire
"5-[(2-chloro-6-fluorophenyl)methylene]-2,2-dimethyl-1,3-dio... Intermediates CS-EL-07575 278597-15-2 Enquire
"5-[(4-acetylanilino)methylene]-2,2-dimethyl-1,3-dioxane-4,6... Intermediates CS-EL-02355 97545-50-1 Enquire
"5-[(4-bromo-2,5-dimethoxyanilino)methylene]-2,2-dimethyl-1,... Intermediates CS-EL-04481 133400-93-8 Enquire
"5-[(benzylsulfanyl)methylene]-2,2-dimethyl-1,3-dioxane-4,6-... Intermediates CS-EL-09412 128889-73-6 Enquire
"5-[(cyclohexylsulfanyl)methylene]-2,2-dimethyl-1,3-dioxane-... Intermediates CS-EL-01675 128889-76-9 Enquire
"5-[(dimethylamino)methyl]-2,2-dimethyl-1,3-dioxane-4,6-dion... Intermediates CS-EL-04691 227201-29-8 Enquire
"5-[1-amino-2-(1H-1,2,4-triazol-1-yl)ethylidene]-2,2-dimethy... Intermediates CS-EL-08589 338405-47-3 Enquire
"5-[1-amino-2-(2,4-dichlorophenoxy)ethylidene]-2,2-dimethyl-... Intermediates CS-EL-08086 338418-52-3 Enquire
"5-[1-amino-2-(4-chlorophenyl)ethylidene]-2,2-dimethyl-1,3-d... Intermediates CS-EL-06173 338406-51-2 Enquire
"5-{[(2,4-dichlorobenzyl)sulfanyl]methylene}-2,2-dimethyl-1,... Intermediates CS-EL-08553 477866-44-7 Enquire
"5-{[(2,4-dichlorophenyl)sulfanyl]methylene}-2,2-dimethyl-1,... Intermediates CS-EL-04819 477866-35-6 Enquire
"5-{[(2-chlorophenyl)sulfanyl]methylene}-2,2-dimethyl-1,3-di... Intermediates CS-EL-02945 477866-32-3 Enquire
"5-{[(3,4-dimethoxyphenethyl)amino]methylene}-2,2-dimethyl-1... Intermediates CS-EL-04516 1020252-23-6 Enquire
"5-{[(3-chlorophenyl)sulfanyl]methylene}-2,2-dimethyl-1,3-di... Intermediates CS-EL-05858 477866-34-5 Enquire
"5-{[(4-chlorobenzyl)sulfanyl]methylene}-2,2-dimethyl-1,3-di... Intermediates CS-EL-07377 477866-43-6 Enquire
"5-{[(4-chlorophenyl)sulfanyl]methylene}-2,2-dimethyl-1,3-di... Intermediates CS-EL-00856 477866-33-4 Enquire
"5-{[2-(diethylamino)-1,3-thiazol-5-yl]methylene}-2,2-dimeth... Intermediates CS-EL-03031 477854-98-1 Enquire
"5-{[4-(benzyloxy)phenyl]methylene}-2,2-dimethyl-1,3-dioxane... Intermediates CS-EL-06958 477863-06-2 Enquire
"5-Bromo-1,4-benzodioxane" Intermediates CS-T-68298 58328-39-5 Enquire
"6-Hydroxy-1,4-benzodioxane 6-Acetate" Intermediates CS-T-26619 7159-14-0 Enquire
"6-Hydroxy-1,4-benzodioxane" Intermediates CS-T-26616 10288-72-9 Enquire
(4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Ac... Intermediates CS-T-51374 125971-94-0 Enquire
(4R,6R)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic Ac... Intermediates CS-T-56168 407577-54-2 In Stock
(4R-cis)-6-formaldehydel-2,2-dimethyl-1, 3-dioxane-4-acetic ... Intermediates CS-O-32238 124752-23-4 In Stock
(4S,6S)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic Ac... Intermediates CS-T-93785 124655-09-0 Enquire
[3’aS-(3’aa,4’a,6’aa)]-Hexahydro-5,5-dimethyl-5’-oxo-spiro[1... Intermediates CS-T-78305 105499-52-3 Enquire
1,3-Dioxane-2-carboxylic acid ethyl ester Intermediates CS-ED-27246 90392-05-5 Enquire
1,4-Benzodioxane-6-carboxaldehyde" Intermediates CS-T-05073 29668-44-8 In Stock
2-(1,3-Dioxane-2-yl)ethyl azide Intermediates CS-ED-36930 284684-16-8 Enquire
2-(2-Bromoethyl)-1,3-dioxane Intermediates CS-T-08934 33884-43-4 In Stock
2-(Chloromethyl)-1,4-dioxane Intermediates CS-M-17129 21048-16-8 Enquire
2,2,5-Trimethyl-1,3-dioxane-5-carboxylic Acid Intermediates CS-T-45626 16837-14-2 Enquire
2,2-Dimethyl-5-({4-[5-(trifluoromethyl)-2-pyridinyl]piperazi... Intermediates CS-ED-25800 1022052-14-7 Enquire
2,2-Dimethyl-5-(3-thienyl)-1,3-dioxane-4,6-dione Intermediates CS-DE-00825 61857-83-8 Enquire
2,3-Dichloro-1,4-dioxane Intermediates CS-ED-26310 95-59-0 Enquire
2,6-Dimethyl-1,4-dioxane Intermediates CS-ED-27064 10138-17-7 Enquire
2-Acetate-6-[(phenylmethoxy)methyl]-1,4-dioxane-2-methanol Intermediates CS-T-64357 338458-98-3 Enquire
2-Bromomethyl-1,4-dioxane Intermediates CS-T-49806 1339058-38-6 Enquire
2-Isopropyl-1,3-dioxane-5-carboxylic Acid Intermediates CS-T-29906 116193-72-7 Enquire
2-tert-Butyl-1,3-dioxane-5-carboxylic Acid Methyl Ester Intermediates CS-T-09566 1159977-17-9 Enquire
5-({[4-(4-Fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}meth... Intermediates CS-ED-29418 946386-70-5 Enquire
5-(1-Hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione Intermediates CS-ED-12052 85920-63-4 Enquire
5-(6-(Benzyloxy)-5-iodonaphthalen-2-yl)-2,2-dimethyl-5-nitro... Intermediates CS-ED-14908 1225349-42-7 Enquire
5-(6-(Benzyloxy)naphthalen-2-yl)-2,2-dimethyl-5-nitro-1,3-di... Intermediates CS-ED-14907 1225347-11-4 Enquire
5-(6-Bromonaphthalen-2-yl)-2,2-dimethyl-5-nitro-1,3-dioxane Intermediates CS-ED-14906 1225347-07-8 Enquire
5,5-Bis-(aminomethyl)-2,2-bis-(methyl)-1,3-dioxane Intermediates CS-ED-25895 104275-10-7 Enquire
5,5-dimethyl-hexahydro-1'H-spiro[1,3-dioxane-2,2'-pentalene]... Intermediates CS-EL-04571 92007-37-9 Enquire
5,6,7,8-Tetrafluorobenzo-1,4-dioxane Intermediates CS-M-01427 1743-87-9 Enquire
5-[(3-chloro-1-benzothiophen-2-yl)methylene]-2,2-dimethyl-1,... Intermediates CS-EL-20777 477868-40-9 Enquire
5-[2-(2-Aminopurin-9-yl)ethyl]-2,2-dimethyl-1,3-dioxane Intermediates CS-ED-26891 104227-89-6 Enquire
5-{[(4-bromophenyl)sulfanyl]methylene}-2,2-dimethyl-1,3-diox... Intermediates CS-EL-06538 477866-37-8 Enquire
5-{[(6-Ethoxy-1,3-benzothiazol-2-yl)amino]methylene}-2,2-dim... Intermediates CS-ED-28200 1023845-26-2 Enquire
5-Benzyl-2,2-dimethyl-1,3-dioxane-4,6-dione Intermediates CS-ED-13774 3709-27-1 Enquire
5-Bromo-5-nitro-1,3-dioxane Intermediates CS-BX-00017 30007-47-7 Enquire
5-Ethyl-2,2-dimethyl-[1,3]dioxane-5-carboxylic acid Intermediates CS-DV-03115 587874-07-5 Enquire
5-Methyl-2-(1-methylbutyl)-5-propyl-1,3-dioxane Intermediates CS-ED-42196 80480-24-6 Enquire
5-Methylspiro[1,3-dioxane-2,2'-tricyclo[3.3.1.1~3,7~]decane]... Intermediates CS-ED-31053 932924-40-8 Enquire
5-Octanoyl-2,2-dimethyl-1,3-dioxane-4,6-dione Intermediates CS-T-37802 103576-44-9 Enquire
5-sec-butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-... Intermediates CS-ED-00544 117933-89-8 Enquire
6-[(Phenylmethoxy)methyl]-1,4-dioxane-2-methanol Intermediates CS-T-60467 79494-95-4 Enquire
6-Chloroacetyl-1,4-benzodioxane Intermediates CS-ED-24138 93439-37-3 Enquire
6-Nitro-1,3-benzodioxane Intermediates CS-T-59346 6963-03-7 Enquire
8-(Chloromethyl)-6-fluorobenzo-1,3-dioxane Intermediates CS-M-01934 131728-94-4 Enquire
Dioxane Bromonium Bromide Intermediates CS-T-20793 15481-39-7 Enquire
trans-2-(4-Cyanophenyl)-5-n-butyl-1,3-dioxane Intermediates CS-H-00187 74800-54-7 Enquire
trans-2-(4-Cyanophenyl)-5-n-pentyl-1,3-dioxane Intermediates CS-H-00186 74800-62-7 Enquire


Fine Chemicals

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
"1,4-Benzodioxane" Fine Chemicals CS-DB-00036 493-09-4 Enquire
1,4-Dioxane Fine Chemicals CS-AZ-00002 123-91-1 In Stock
2,2'-(1,4-dioxane-2,5-diyl)diethanol Fine Chemicals CS-O-54742 854841-54-6 Enquire
5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione Fine Chemicals CS-M-30991 15568-85-1 In Stock
5,5-Bis(hydroxymethyl)-2-phenyl-1,3-dioxane Fine Chemicals CS-ED-42238 2425-41-4 Enquire
6-(Bromomethyl)-2,3-dihydrobenzo[b][1,4]dioxane Fine Chemicals CS-O-52251 79440-34-9 Enquire
6-Bromo-1,4-benzodioxane Fine Chemicals CS-M-03074 52287-51-1 Enquire


Building Blocks

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
"1,4-Benzodioxane-6-boronic acid" Building Blocks CS-M-03508 164014-95-3 Enquire