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Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Isoquinoline, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Isoquinoline impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Isoquinoline-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.

Isoquinoline Related Compounds

Stable Isotopes

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(4R)-4,6-Dihydroxy-2-methyl-1-(3-methoxy-4-hydroxyphenyl)-1,... Stable Isotopes CS-T-97583 Not Available Enquire
(4R)-4,6-Dihydroxy-2-methyl-1-phenyl-1,2,3,4-tetrahydroisoqu... Stable Isotopes CS-T-97582 Not Available Enquire
(S)-4-Nitrophenyl 1-Phenyl-d5-3,4-dihydroisoquinoline-2(1H)-... Stable Isotopes CS-T-97262 Not Available Enquire
1,2,3,4-Tetrahydro-1,2-dimethyl-4,6-isoquinolinediol-d3 Stable Isotopes CS-T-102043 Not Available Enquire
1,2,3,4-tetrahydro-1,2-dimethyl-4,8-isoquinolinediol-d3 Stable Isotopes CS-T-102042 Not Available Enquire
2-(1,1-Dimethylethyl)-1,2,3,4-tetrahydro-4,6,8-Isoquinolinet... Stable Isotopes CS-T-101467 Not Available Enquire
rac-(4R)-4,6-Dihydroxy-2-methyl-1,2,3,4-tetrahydroisoquinoli... Stable Isotopes CS-T-97584 Not Available Enquire


Impurity

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(1-chloro-4-hydroxyisoquinoline-3-carbonyl)cysteine Impurity CS-O-46711 Not Available Enquire
(1R,4R)-2-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-4,6... Impurity CS-O-43306 2095343-25-0 Enquire
(1R,4R)-2-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-4,8... Impurity CS-O-43307 Not Available Enquire
(1S,4R)-2-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-4,6... Impurity CS-O-43305 2095343-19-2 Enquire
(1S,4R)-2-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-4,8... Impurity CS-O-43308 Not Available Enquire
(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)-L-seri... Impurity CS-O-54974 ---- Enquire
(S)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinolin... Impurity CS-O-49393 30356-07-1 Enquire
1,2,3,4-Tetrahydro-4,6-dihydroxy-2-methylisoquinoline Hydroc... Impurity CS-O-11270 57196-61-9 In Stock
2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)but-3-ynoic ... Impurity CS-O-46712 Not Available Enquire
2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)oxirane-2-ca... Impurity CS-O-46710 Not Available Enquire
2-(tert-butoxycarbonyl)-5-chloro-1,2,3,4-tetrahydroisoquinol... Impurity CS-SN-00099 Not Available Enquire
2-(tert-butoxycarbonyl)-7-chloro-1,2,3,4-tetrahydroisoquinol... Impurity CS-SN-00100 Not Available Enquire
2,2'-((4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)a... Impurity CS-O-54972 ---- Enquire
4-fluoroisoquinoline-8-sulfonyl chloride hydrochloride Impurity CS-O-52991 1334294-10-8 Enquire
4-hydroxy-1-oxo-7-phenoxy-1,2-dihydroisoquinoline-3-carboxyl... Impurity CS-O-54971 2342600-70-6 Enquire
5-bromo-2-(tert-butoxycarbonyl)-7-chloro-1,2,3,4-tetrahydroi... Impurity CS-O-49952 2832127-60-1 Enquire
6, 7-dimethoxy-1 -(3,4, 5-trimethoxy-benzyl) isoquinoline Impurity CS-O-43996 Not Available Enquire
Isoquinoline-4,6-diol Impurity CS-ED-41712 1780813-78-6 Enquire
Isoquinoline-8-carboxylic acid Impurity CS-O-16465 61563-43-7 In Stock
N-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)-N-me... Impurity CS-O-54973 ---- Enquire
N-Bocdesisoquinoline Netarsudil impurity Impurity CS-O-57156 2097334-20-6 Enquire
Phenylephrine 4,8 Isoquinoline Analog Impurity CS-O-48658 2514676-44-7 Enquire
Phenylephrine 4,8 Isoquinoline Analog Impurity CS-O-15944 23824-25-1 In Stock
Phenylephrine 4,8 Isoquinoline Hydrochloride analog Impurity CS-O-11269 23824-25-1 (Free Base) In Stock
Phenylephrine isoquinoline 4,6-diol analog Impurity CS-O-36024 23824-24-0 In Stock
Solifenacin Impurity (4-Nitrophenyl (1S)-1-Phenyl-3-4-Dihidr... Impurity CS-O-14496 1229227-22-8 In Stock
(+) N-formyl-1-(p-methoxybenzyl) 1,2,3,4,5,6,7,8 octa-hydro ... Impurity CS-O-37323 63477-91-8 Enquire
(1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)glycine Impurity CS-ED-01076 808116-60-1 Enquire
(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)glycine Impurity CS-ED-01075 708263-68-7 Enquire
(S)-2-(2-(benzofuran-6-carbonyl )-5,7-dichloro-1,2,3,4-tetra... Impurity CS-O-38472 Not Available Enquire
(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2-dihydroiso... Impurity CS-O-38470 Not Available Enquire
3-((Carboxymethyl)carbamoyl)-4-hydroxy-1-methyl-7-phenoxyiso... Impurity CS-O-36231 Not Available Enquire
5-Bromo-3,4-dihydro-1H-isoquinoline-2-carboxylic Acid tert-B... Impurity CS-T-67562 215184-78-4 Enquire
7-​methoxy-​4-​(4-​methoxy-​benzyl)​-​isoquinoline Impurity CS-O-42193 101733-93-1 Enquire
Boc amino isoquinoline impurity Impurity CS-O-37706 1253955-19-9 Enquire
Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrah... Impurity CS-CB-00037 1699-51-0 Enquire
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Impurity CS-O-31721 74163-81-8 Enquire
Samidorphan isoquinoline dioxolane Impurity CS-O-51248 361525-83-9 Enquire
Samidorphan methanobenzofuron isoquinoline Impurity CS-O-51249 421552-35-4 Enquire


Intermediate

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline Intermediate CS-O-31497 118864-75-8 In Stock
1,2,3,4-Tetrahydroisoquinoline Intermediate CS-T-86916 91-21-4 In Stock
3-phenylisoquinoline-1-carboxylic acid Intermediate CS-O-55444 92566-89-7 Enquire
5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline Hydrochloride Intermediate CS-O-57676 73075-47-5 Enquire
5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic Aci... Intermediate CS-BX-01103 1289646-93-0 In Stock
5,7-Dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline Intermediate CS-O-57658 1289646-72-5 Enquire
5,7-Dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carbo... Intermediate CS-O-57659 1194550-56-5 Enquire
6,7-Dimethoxy-3,4-Dihydroisoquinoline Intermediate CS-EL-00945 3382-18-1 In Stock
6-Aminoisoquinoline Intermediate CS-M-52909 23687-26-5 In Stock
6-Isopropylisoquinoline Intermediate CS-O-47532 790304-84-6 Enquire
7-bromo-2-(tert-butoxycarbonyl)-5-chloro-1,2,3,4-tetrahydroi... Intermediate CS-O-49951 2832100-74-8 Enquire


Fine Chemicals

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(S)-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid Fine Chemicals CS-MM-50763 151004-92-1 In Stock
6,7-Dimethoxyisoquinoline Fine Chemicals CS-AC-10942 15248-39-2 In Stock
8-Bromo-5-methoxy-1,2,3,4-tetrahydroisoquinoline Fine Chemicals CS-O-49980 392660-50-3 Enquire
Isoquinoline Fine Chemicals CS-T-30055 119-65-3 In Stock
Isoquinoline-6-carboxylic acid Fine Chemicals CS-O-16464 106778-43-2 In Stock
(R)-(+)-1-(2-Diphenylphosphino-1-naphthyl)isoquinoline Fine Chemicals CS-BX-01050 149341-34-4 Enquire
(S)-(−)-1-(2-Diphenylphosphino-1-naphthyl)isoquinoline Fine Chemicals CS-BX-01051 149341-33-3 Enquire
1,2,3,4-Tetrahydroisoquinoline-4,5,8-triol hydrochloride Fine Chemicals CS-O-35257 15052-02-5 Enquire
4-Acetylisoquinoline Fine Chemicals CS-O-38038 40570-74-9 Enquire
4-Fluoro-5-{[(2R)-2-methyl-1,4-diazepan-1-yl]sulfonyl}isoqui... Fine Chemicals CS-O-37142 Not Available Enquire
methyl 1-(acetoxymethyl)-4-hydroxy-6-phenoxyisoquinoline-3-c... Fine Chemicals CS-O-37251 1959587-35-9 Enquire
tert-Butyl 7-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate Fine Chemicals CS-MM-27050 258515-65-0 Enquire


Nitrosamine

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
1-(4-methoxybenzyl)-2-nitrosodecahydroisoquinoline Nitrosamine CS-O-53829 ---- Enquire
DL-DOPA tetrahydroisoquinoline Nitroso impurity Nitrosamine CS-O-57563 ---- Enquire


Stable Isotope Reagent

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
3,4-Dihydro-6,7-di(methoxy-d3)-Isoquinoline Hydrochloride Stable Isotope Reagent CS-EO-03896 1783808-87-6 Enquire


Building Blocks

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
1,3-Dichloro-6-fluoroisoquinoline Building Blocks CS-O-46873 1041423-26-0 Enquire
1-hydroxyisoquinoline-5-carboxylic acid Building Blocks CS-O-45042 212374-18-0 Enquire
4-fluoroisoquinoline-5-sulfonyl chloride Building Blocks CS-BX-01332 194032-33-2 Enquire
6'-bromo-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-isoquinoli... Building Blocks CS-O-48762 1780107-29-0 Enquire
6'-bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinol... Building Blocks CS-O-48761 2167621-83-0 Enquire
6-Bromoisoquinoline-1,3-diol Building Blocks CS-O-48730 1956382-48-1 Enquire
4-Bromoisoquinoline-1-carboxylic Acid Building Blocks CS-TA-64851 1179149-25-7 Enquire
S)-N-Fmoc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid Building Blocks CS-M-29737 136030-33-6 Enquire
Tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate Building Blocks CS-ZE-19509 893566-75-1 Enquire


Chiral

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
R-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid Chiral CS-BB-00042 103733-65-9 In Stock