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Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Methotrexate, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Methotrexate impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Methotrexate-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.

Methotrexate Related Compounds

Stable Isotopes

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(R)-Methotrexate-d3 Stable Isotopes CS-T-100078 Not Available Enquire
7-Cyanomethotrexate Dimethyl Ester-D3 Stable Isotopes CS-T-102563 432545-61-4 Enquire
7-Hydroxy Methotrexate-d3 Ammonium Salt Stable Isotopes CS-T-101293 Not Available Enquire
7-Hydroxymethotrexate D5 Stable Isotopes CS-O-48615 5939-37-7 (Unlabelled) Enquire
DL-Methotrexate-d3 Dipotassium Salt Stable Isotopes CS-T-97330 Not Available Enquire
Methotrexate Pentaglutamate-13C5, 15N Stable Isotopes CS-T-100077 Not Available Enquire
Methotrexate-d3 Stable Isotopes CS-O-06766 432545-63-6 In Stock
Methotrexate-d3 (100ug/mL in Methanol with 1% 0.1N NaOH) Stable Isotopes CS-T-103177 59-05-2(Unlabelled) Enquire
Methotrexate-d3 Diglutamate TFA Sulfate Stable Isotopes CS-T-97328 Not Available Enquire
Methotrexate-d3 Heptaglutamate Trifluoroacetate Stable Isotopes CS-T-97329 Not Available Enquire
Methotrexate-d3 Hexaglutamate Trifluoroacetic Acid Salt Stable Isotopes CS-T-97324 Not Available Enquire
Methotrexate-d3 Pentaglutamate Trifluoroacetate Stable Isotopes CS-T-97325 Not Available Enquire
Methotrexate-d3 Tetraglutamate Trifluoroacetate Stable Isotopes CS-T-97326 Not Available Enquire
Methotrexate-d3 Triglutamate Trifluoroacetate Stable Isotopes CS-T-97327 Not Available Enquire
Methotrexate 13CD3 Stable Isotopes CS-O-37441 1786417-03-5 Enquire
Methotrexate D7 Triglutamate Stable Isotopes CS-O-32925 59-05-2 (Unlabeled) Enquire
Methotrexate-d3 Dimethyl Ester Stable Isotopes CS-T-80367 432545-60-3 Enquire


API

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Methotrexate API CS-O-30641 59-05-2 In Stock
Methotrexate Dihydrate API CS-EO-03682 1212284-68-8 Enquire
Methotrexate Disodium Salt API CS-T-80712 7413-34-5 In Stock
Methotrexate Disodium Tetrahydrate API CS-EO-03684 59-05-2 (Freebase) Enquire
Methotrexate Sodium API CS-O-01873 ---- In Stock
Methotrexate hydrate API CS-EK-01959 59-05-2 anhydrous base Enquire


Metabolite

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
7-Hydroxymethotrexate Metabolite CS-EK-00154 5939-37-7 Enquire


Impurity

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
7-Hydroxymethyl Methotrexate impurity A Impurity CS-O-45505 Not Available Enquire
Methotrexate - Impurity L (Zinc Salt) Impurity CS-O-58972 66104-81-2 Enquire
Methotrexate diethyl ester Impurity CS-ED-41657 43170-88-3 Enquire
Methotrexate Dimethylester Hydrochloride Impurity CS-SN-00175 ---- Enquire
Methotrexate EP Impurity A Impurity CS-T-40938 945-24-4 In Stock
Methotrexate EP Impurity B Impurity CS-M-42743 54-62-6 In Stock
Methotrexate EP Impurity B (MonoHydrate) Impurity CS-O-48766 1217459-90-9 Enquire
Methotrexate EP Impurity B Disodium salt Impurity CS-O-46067 58602-66-7 Enquire
Methotrexate EP Impurity C Impurity CS-T-33870 2410-93-7 In Stock
Methotrexate EP Impurity D Impurity CS-T-34871 5623-18-7 In Stock
Methotrexate EP Impurity E Impurity CS-T-14358 19741-14-1 In Stock
Methotrexate EP Impurity F Impurity CS-O-15235 51865-79-3 In Stock
Methotrexate EP Impurity G Impurity CS-EO-00339 2519848-42-9 In Stock
Methotrexate EP Impurity H Impurity CS-T-32162 67022-39-3 In Stock
Methotrexate EP Impurity I Impurity CS-T-32161 66147-29-3 In Stock
Methotrexate EP Impurity J Impurity CS-T-32157 34378-65-9 In Stock
Methotrexate EP Impurity L Impurity CS-T-33045 52980-68-4 In Stock
Methotrexate EP Imputity-L disodium salt Impurity CS-O-53078 57444-71-0 Enquire
Methotrexate N -methyl 5-oxopentanoic acid Impurity CS-O-53508 ---- Enquire
Methotrexate-(4-Chlorobenzoyl)-L-glutamic Acid-impurity Impurity CS-O-58969 57444-70-9 Enquire
Methotrexate-methyl-benzoyl-diethyl ester impurity Impurity CS-O-58971 70539-58-1 Enquire
R-Methotrexate di sodium Impurity CS-O-48393 Not Available Enquire
6-Methyl-2,4-pteridinediamine Impurity CS-EO-00799 708-74-7 Enquire
Lysine-methotrexate Impurity CS-T-85083 80407-56-3 Enquire
Methotrexate - Impurity E (HCl Salt) Impurity CS-O-40683 70844-48-3 Enquire
Methotrexate Dimethylamide Impurity CS-T-81347 71074-44-7 Enquire
Methotrexate Impurity 15 Impurity CS-P-09235 65148-64-3 Enquire
Methotrexate Impurity 16 Impurity CS-EO-04077 65148-63-2 Enquire
Mixture of Methotrexate EP Impurity H, I, J and L for system... Impurity CS-EG-03398 ---- Enquire


Glucuronide

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Diethyl n-[4-(methylamino)benzoyl]-d-glutamate Glucuronide CS-ED-00740 51865-66-8 Enquire


Nitrosamine

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(R)-Methotrexate N-nitroso Impurity Nitrosamine CS-O-46623 Not Available Enquire
Methotrexate Nitroso Impurity 1 Nitrosamine CS-O-46621 Not Available Enquire
Methotrexate Nitroso Impurity 1 Nitrosamine CS-O-42526 Not Available Enquire
Methotrexate Nitroso Impurity 2 Nitrosamine CS-EO-04020 Not Available Enquire
N, N-Dinitroso Methotrexate EP Impurity L Nitrosamine CS-O-42522 Not Available Enquire
N-Desmethyl Methotrexate dinitroso impurity Nitrosamine CS-O-46622 Not Available Enquire
N-Dinitroso Methotrexate Impurity 2 Nitrosamine CS-O-46625 Not Available Enquire
N-Nitroso diethyl ester Methotrexate EP Impurity-L Nitrosamine CS-O-45484 Not Available Enquire
N-Nitroso Methotrexate Nitrosamine CS-O-48907 Not Available Enquire
N-Nitroso Methotrexate EP Impurity-L (1) Nitrosamine CS-O-42524 Not Available Enquire
N-Nitroso Methotrexate EP Impurity-L (2) Nitrosamine CS-O-42523 Not Available Enquire
N-nitroso Methotrexate Ethylester impurity Nitrosamine CS-O-46627 Not Available Enquire
N-nitroso Methotrexate Impurity 2 Nitrosamine CS-O-46624 Not Available Enquire
N-nitrosobenzamido Methotrexate Impurity 2 Nitrosamine CS-O-46626 Not Available Enquire


Secondary Standards

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Methotrexate Secondary Standards CS-SS-24394-1GM 59-05-2 Enquire
Methotrexate Related Compound E Secondary Standards CS-SS-26332 70844-48-3 Enquire
R-Methotrexate Secondary Standards CS-SS-26333 51865-79-3 Enquire


Analytical Standard

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Methotrexate-d3 AR Grade Analytical Standard CS-O-06766-10MG 432545-63-6 Enquire
Methotrexate-d3 AR Grade-10 ppm/ACN Analytical Standard CS-O-06766-1ML 432545-63-6 Enquire


Biochemicals

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Methotrexate Hydrate (MTR), 98% Biochemicals CS-SR-00349 133073-73-1 Enquire


Building Blocks

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
D-Methotrexate Disodium salt Building Blocks CS-O-48390 Not Available Enquire


EP Standards

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
METHOTREXATE IMPURITY C (EP GRADE) EP Standards CS-EG-03296 2410-93-7 Enquire
Methotrexate EP EP Standards CS-EG-03297 59-05-2 Enquire
METHOTREXATE IMPURITY D (EP GRADE) EP Standards CS-EG-03295 5623-18-7 Enquire
Methotrexate System Suitability Mixture (Mixture of Methotre... EP Standards CS-EG-03319 Not Available Enquire