Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Methotrexate, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Methotrexate impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Methotrexate-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.
Our Methotrexate-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.
Methotrexate Related Compounds
Stable Isotopes
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (R)-Methotrexate-d3 | Stable Isotopes | CS-T-100078 | Not Available | Enquire |
| 7-Cyanomethotrexate Dimethyl Ester-D3 | Stable Isotopes | CS-T-102563 | 432545-61-4 | Enquire |
| 7-Hydroxy Methotrexate-d3 Ammonium Salt | Stable Isotopes | CS-T-101293 | Not Available | Enquire |
| 7-Hydroxymethotrexate D5 | Stable Isotopes | CS-O-48615 | 5939-37-7 (Unlabelled) | Enquire |
| DL-Methotrexate-d3 Dipotassium Salt | Stable Isotopes | CS-T-97330 | Not Available | Enquire |
| Methotrexate Pentaglutamate-13C5, 15N | Stable Isotopes | CS-T-100077 | Not Available | Enquire |
| Methotrexate-d3 | Stable Isotopes | CS-O-06766 | 432545-63-6 | In Stock |
| Methotrexate-d3 (100ug/mL in Methanol with 1% 0.1N NaOH) | Stable Isotopes | CS-T-103177 | 59-05-2(Unlabelled) | Enquire |
| Methotrexate-d3 Diglutamate TFA Sulfate | Stable Isotopes | CS-T-97328 | Not Available | Enquire |
| Methotrexate-d3 Heptaglutamate Trifluoroacetate | Stable Isotopes | CS-T-97329 | Not Available | Enquire |
| Methotrexate-d3 Hexaglutamate Trifluoroacetic Acid Salt | Stable Isotopes | CS-T-97324 | Not Available | Enquire |
| Methotrexate-d3 Pentaglutamate Trifluoroacetate | Stable Isotopes | CS-T-97325 | Not Available | Enquire |
| Methotrexate-d3 Tetraglutamate Trifluoroacetate | Stable Isotopes | CS-T-97326 | Not Available | Enquire |
| Methotrexate-d3 Triglutamate Trifluoroacetate | Stable Isotopes | CS-T-97327 | Not Available | Enquire |
API
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Methotrexate | API | CS-O-30641 | 59-05-2 | In Stock |
| Methotrexate Dihydrate | API | CS-EO-03682 | 1212284-68-8 | Enquire |
| Methotrexate Disodium Salt | API | CS-T-80712 | 7413-34-5 | In Stock |
| Methotrexate Disodium Tetrahydrate | API | CS-EO-03684 | 59-05-2 (Freebase) | Enquire |
| Methotrexate Sodium | API | CS-O-01873 | ---- | In Stock |
Impurity
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| 6-Methyl-2,4-pteridinediamine | Impurity | CS-EO-00799 | 708-74-7 | Enquire |
| 7-Hydroxymethyl Methotrexate impurity A | Impurity | CS-O-45505 | Not Available | Enquire |
| Methotrexate - Impurity E (HCl Salt) | Impurity | CS-O-40683 | 70844-48-3 | Enquire |
| Methotrexate - Impurity L (Zinc Salt) | Impurity | CS-O-58972 | 66104-81-2 | Enquire |
| Methotrexate diethyl ester | Impurity | CS-ED-41657 | 43170-88-3 | Enquire |
| Methotrexate Dimethylamide | Impurity | CS-T-81347 | 71074-44-7 | Enquire |
| Methotrexate Dimethylester Hydrochloride | Impurity | CS-SN-00175 | ---- | Enquire |
| Methotrexate EP Impurity A | Impurity | CS-T-40938 | 945-24-4 | In Stock |
| Methotrexate EP Impurity B | Impurity | CS-M-42743 | 54-62-6 | In Stock |
| Methotrexate EP Impurity B (MonoHydrate) | Impurity | CS-O-48766 | 1217459-90-9 | Enquire |
| Methotrexate EP Impurity B Disodium salt | Impurity | CS-O-46067 | 58602-66-7 | Enquire |
| Methotrexate EP Impurity C | Impurity | CS-T-33870 | 2410-93-7 | In Stock |
| Methotrexate EP Impurity D | Impurity | CS-T-34871 | 5623-18-7 | In Stock |
| Methotrexate EP Impurity F | Impurity | CS-O-15235 | 51865-79-3 | In Stock |
| Methotrexate EP Impurity G | Impurity | CS-EO-00339 | 2519848-42-9 | In Stock |
| Methotrexate EP Impurity H | Impurity | CS-T-32162 | 67022-39-3 | In Stock |
| Methotrexate EP Impurity I | Impurity | CS-T-32161 | 66147-29-3 | In Stock |
| Methotrexate EP Impurity J | Impurity | CS-T-32157 | 34378-65-9 | In Stock |
| Methotrexate EP Impurity L | Impurity | CS-T-33045 | 52980-68-4 | Enquire |
| Methotrexate EP Imputity-L disodium salt | Impurity | CS-O-53078 | 57444-71-0 | In Stock |
| Methotrexate N -methyl 5-oxopentanoic acid | Impurity | CS-O-53508 | ---- | Enquire |
| Methotrexate-(4-Chlorobenzoyl)-L-glutamic Acid-impurity | Impurity | CS-O-58969 | 57444-70-9 | Enquire |
| Methotrexate-methyl-benzoyl-diethyl ester impurity | Impurity | CS-O-58971 | 70539-58-1 | Enquire |
| R-Methotrexate di sodium | Impurity | CS-O-48393 | Not Available | Enquire |
Glucuronide
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Diethyl n-[4-(methylamino)benzoyl]-d-glutamate | Glucuronide | CS-ED-00740 | 51865-66-8 | Enquire |
Nitrosamine
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (R)-Methotrexate N-nitroso Impurity | Nitrosamine | CS-O-46623 | Not Available | Enquire |
| Methotrexate Nitroso Impurity 1 | Nitrosamine | CS-O-46621 | Not Available | Enquire |
| Methotrexate Nitroso Impurity 1 | Nitrosamine | CS-O-42526 | Not Available | Enquire |
| Methotrexate Nitroso Impurity 2 | Nitrosamine | CS-EO-04020 | Not Available | Enquire |
| N, N-Dinitroso Methotrexate EP Impurity L | Nitrosamine | CS-O-42522 | Not Available | Enquire |
| N-Desmethyl Methotrexate dinitroso impurity | Nitrosamine | CS-O-46622 | Not Available | Enquire |
| N-Dinitroso Methotrexate Impurity 2 | Nitrosamine | CS-O-46625 | Not Available | Enquire |
| N-Nitroso diethyl ester Methotrexate EP Impurity-L | Nitrosamine | CS-O-45484 | Not Available | Enquire |
| N-Nitroso Methotrexate | Nitrosamine | CS-O-48907 | Not Available | Enquire |
| N-Nitroso Methotrexate EP Impurity-L (1) | Nitrosamine | CS-O-42524 | Not Available | Enquire |
| N-Nitroso Methotrexate EP Impurity-L (2) | Nitrosamine | CS-O-42523 | Not Available | Enquire |
| N-nitroso Methotrexate Ethylester impurity | Nitrosamine | CS-O-46627 | Not Available | Enquire |
| N-nitroso Methotrexate Impurity 2 | Nitrosamine | CS-O-46624 | Not Available | Enquire |
| N-nitrosobenzamido Methotrexate Impurity 2 | Nitrosamine | CS-O-46626 | Not Available | Enquire |
Building Blocks
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| D-Methotrexate Disodium salt | Building Blocks | CS-O-48390 | Not Available | Enquire |
EP Standards
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| METHOTREXATE IMPURITY C (EP GRADE) | EP Standards | CS-EG-03296 | 2410-93-7 | Enquire |
| Methotrexate System Suitability Mixture (Mixture of Methotre... | EP Standards | CS-EG-03319 | Not Available | Enquire |
Therapeutic
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Methotrexate EP Impurity E | Therapeutic | CS-T-14358 | 19741-14-1 | In Stock |