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Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Nicotine, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Nicotine impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Nicotine-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.

Nicotine Related Compounds

Stable Isotopes

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(R)-Anabasine-d4 Stable Isotopes CS-T-94109 34366-21-7 (Unlabelled) Enquire
(R)-Nicotine-d3 N-β-D-Glucuronide Stable Isotopes CS-T-97265 Not Available Enquire
(R)-N'-Nitrosonornicotine-d4 Stable Isotopes CS-P-08860 61601-78-3 (Unlabelled) Enquire
(S)-Nicotine-d3 N-b-D-Glucuronide Stable Isotopes CS-T-97266 Not Available Enquire
Isonicotine-d3 Stable Isotopes CS-T-98780 1346601-08-8 Enquire
Mixture of  (R,S)-N-Nitroso Anabasine-d4, rac N’-Nitrosonorn... Stable Isotopes CS-T-98765 Not Available Enquire
N-Formylnornicotine-D4 Stable Isotopes CS-T-103948 3000-81-5(unlabelled) Enquire
Nicotine-d3 Stable Isotopes CS-O-06811 69980-24-1 In Stock
Nicotine-d3 N-(4-Deoxy-4,5-didehydro)-b-D-glucuronide Stable Isotopes CS-T-97267 Not Available Enquire
N-Nitrosonornicotine-2,4,5,6-d4(Pyridine-d4) Stable Isotopes CS-O-02685 66148-19-4 In Stock
rac-N’-Nitrosonornicotine-d4 1-N-Oxide Stable Isotopes CS-T-102179 Not Available Enquire
rac-Nicotine-d4 Stable Isotopes CS-T-59260 350818-69-8 In Stock
rac-Nicotine-d7 (N-methyl-d3; pyridine-d4) Stable Isotopes CS-T-94964 1219805-86-3 In Stock
(±)-Nicotine-D3 salicylate Stable Isotopes CS-W-00398 1173021-00-5 Enquire
(±)-Nornicotine-2,2',3',3',4,5,6-d7 Stable Isotopes CS-C-01436 5746-86-1 (Unlabelled) Enquire
(2'S)- Nicotine 1-Oxide-d4 Stable Isotopes CS-O-34780 2820-55-5 Enquire
(2S)-N'-Nitrosonornicotine-d4 Stable Isotopes CS-T-59638 1426174-36-8 Enquire
(R)-Nornicotine-d4 Stable Isotopes CS-T-59754 1259761-67-5 Enquire
(R,S)-Nornicotine D4 Stable Isotopes CS-T-59755 66148-18-3 Enquire
(R,S)-Nornicotine-13C6 Stable Isotopes CS-T-97254 Not Available Enquire
(S)-(-)-Nicotine-15N Stable Isotopes CS-T-83661 72496-00-5 Enquire
(S)-(-)-Nicotine-d3 Stable Isotopes CS-T-94965 Not Available Enquire
(S)-(-)-Nicotine-d4 Stable Isotopes CS-T-59262 284685-07-0 Enquire
(S)-Nornicotine D4 Stable Isotopes CS-T-59753 92761-98-3 Enquire
5-Methylnicotine D3 Stable Isotopes CS-T-58435 1190016-33-1 Enquire
Methyl Metanicotine-d3 Stable Isotopes CS-T-58403 220088-40-4 Enquire
Nicotelline D8 Stable Isotopes CS-T-59248 1469367-99-4 Enquire
Nicotine-D3-β-D-Glucuronide Stable Isotopes CS-T-59175 329002-74-6 Enquire
rac N'-Nitrosonornicotine-d4 with (R,S)-N-Nitroso Anabasine-... Stable Isotopes CS-T-95148 Not Available Enquire
rac-Nicotine 13CD3 Stable Isotopes CS-T-59259 909014-86-4 Enquire
rac-Nicotine 1-Oxide-d4 Stable Isotopes CS-O-34782 23113-16-8 Enquire
rac-Nicotine-1,2’,3’,4’,5’,6’-13C6 Stable Isotopes CS-T-82953 1189715-49-8 Enquire
rac-Nicotine-2',3',3'-d3 Stable Isotopes CS-T-59258 1189681-48-8 Enquire
rac-Nicotine-d3 N-β-D-Glucuronide Stable Isotopes CS-T-94966 Not Available Enquire
rac-trans-Nicotine-1’-oxide-d3 Stable Isotopes CS-T-94967 Not Available Enquire
S-(-)-NICOTINE-D1-(5)-IMINIUM DIPERCHLORATE SALT Stable Isotopes CS-T-59176 71014-67-0 Enquire


API

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(S)-(-)-Nicotine API CS-T-36553 54-11-5 In Stock
(S)-Anabasine API CS-T-48180 494-52-0 In Stock
Isonicotinamide API CS-T-29786 1453-82-3 In Stock
Nicotine Ditartrate Dihydrate API CS-O-30688 6019-06-3 In Stock
Nicotine lactate API CS-ED-41628 14474-00-1 Enquire
Nicotine Malate API CS-T-96130 73057-36-0 Enquire
2-Methyl Nornicotine API CS-T-34709 64114-19-8 Enquire
Myosmine API CS-M-05066 532-12-7 Enquire
Nicotine bitartrate API CS-O-30986 2624-48-8 Enquire


Metabolite

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Nicotinuric Acid Metabolite CS-O-03508 583-08-4 In Stock
Nudifloramide Metabolite CS-O-10017 701-44-0 Enquire


Impurity

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(+/-)-N-Ethoxycarbonylnornicotine Impurity CS-T-54301 74245-32-2 In Stock
(1'R,2'S)-Nicotine 1'-Oxide Impurity CS-EO-02161 51020-67-8 Enquire
(S)-Nicotine-N-oxide Impurity CS-EU-00053 491-26-9 In Stock
Benzyl nicotinate Impurity CS-CG-00214 94-44-0 In Stock
Ethyl Nicotinate HCl Impurity CS-EO-03725 65550-28-9 Enquire
Nicotine Related Compound D Impurity CS-O-45829 532-12-7 (Freebase) Enquire
Nicotine Related Compound E Impurity CS-O-45830 491-26-9 (Freebase) In Stock
Rac-Anabasine DiHCl Impurity CS-EO-03726 143924-48-5 Enquire
(1RS,2S)-Nicotine 1,1-Di-N-Oxide Impurity CS-T-59266 129547-84-8 Enquire
(2'S)-Nicotine 1-Oxide Impurity CS-T-59271 2820-55-5 Enquire
(RS)-3-Bromo Nornicotine Impurity CS-T-08705 71719-06-7 Enquire
(S)-6-Chloro-4-iodonicotine Impurity CS-T-11800 913264-28-5 Enquire
(S)-6-Chloro-5-iodonicotine Impurity CS-T-11801 909193-59-5 Enquire
(S)-6-Chloronicotine Impurity CS-T-12052 112091-17-5 Enquire
(S)-6-Hydroxy Nicotine Impurity CS-T-56251 10516-09-3 Enquire
(S)-6-Methoxynicotine Impurity CS-T-79904 224569-41-9 Enquire
(S)-Nornicotine Impurity CS-T-59752 494-97-3 Enquire
5-Methyl Nornicotine Impurity CS-T-34710 126741-11-5 Enquire
6-Methyl Nornicotine Impurity CS-T-34711 90872-72-3 Enquire
Isonicotine Impurity CS-T-29788 92118-22-4 Enquire
N-Boc (RS)-Nornicotine Impurity CS-T-07649 1076199-53-5 Enquire
N-Ethyl (S)-Nornicotine Impurity CS-T-74733 5979-92-0 Enquire
R-(R)-Nicotine Impurity CS-T-59261 25162-00-9 Enquire
rac-trans 3’-Acetylthiomethyl Nicotine Impurity CS-T-65218 1217716-10-3 Enquire
rac-trans 3’-Hydroxymethylnicotine Impurity CS-T-79364 71771-91-0 Enquire
rac-trans 3'-Aminomethyl Nicotine Impurity CS-T-03016 623579-03-3 Enquire
rac-trans 3'-Hydroxymethylnicotine Hemisuccinate Impurity CS-T-56226 1207282-59-4 Enquire
rac-trans 3'-Hydroxymethylnicotine Hemisuccinate N-Hydroxysu... Impurity CS-T-56227 1207282-60-7 Enquire
rac-trans 3'-Thiomethyl Nicotine Dihydrochloride Impurity CS-T-62022 1246820-13-2 Enquire
trans-3′-(Hydroxymethyl)nicotine Impurity CS-T-56225 33224-02-1 Enquire


Intermediate

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(1S,2S)-Nicotine 1-Oxide Intermediate CS-T-59177 51095-86-4 In Stock
N-Formylnornicotine Intermediate CS-T-24746 3000-81-5 In Stock


Glucuronide

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Nicotinic Acid Acyl-β-D-glucuronide Glucuronide CS-T-59280 24719-73-1 Enquire
Nicotine-β-D-Glucuronide Glucuronide CS-T-59270 153536-53-9 Enquire


Fine Chemicals

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Nicotine Hydrogen Tartrate Fine Chemicals CS-T-82860 65-31-6 Enquire
rac-5-Methylnicotine Fine Chemicals CS-T-34481 82111-06-6 Enquire


Nitrosamine

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(2S)-N'-Nitrosonornicotine Nitrosamine CS-T-37266 16543-55-8 In Stock
(R,S)-N-Nitroso Anabasine HCl salt Nitrosamine CS-EO-03727 37620-20-5 (Freebase) Enquire
rac-N-Nitroso Nornicotine Nitrosamine CS-T-37265 80508-23-2 In Stock
(R)-N-Nitrosonornicotine Nitrosamine CS-T-37274 61601-78-3 Enquire
N’-Nitroso nornicotine-1-N-Oxide Nitrosamine CS-O-39105 Not Available Enquire
N’-Nitrosonornicotine-N-b-D-glucuronide Nitrosamine CS-T-83679 864071-82-9 Enquire
N'-Nitrosonornicotine-β-D-Glucuronide X Hydrate Nitrosamine CS-T-59639 350508-25-7 Enquire
N'-Nitrosonornicotine-5-carboxylic Acid Nitrosamine CS-T-37272 1076199-27-3 Enquire
rac N'-Nitrosonornicotine 5'-Acetate Nitrosamine CS-T-37264 68743-65-7 Enquire
rac-N-Nitrosonornicotine 1-N-Oxide Nitrosamine CS-T-59640 1314916-69-2 Enquire


Secondary Standards

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Nicotine bitartrate dihydrate Secondary Standards CS-SS-25356-500MG 6019-06-3 Enquire
Nicotine Related Compound A/EP Impurity A Secondary Standards CS-SS-25767-50MG 2743-90-0 Enquire
Nicotine Related Compound B Secondary Standards CS-SS-25768-50MG 487-19-4 Enquire
Nicotine Related Compound C Secondary Standards CS-SS-25357-50MG 486-56-6 Enquire
Nicotine Related Compound D Secondary Standards CS-SS-25769-50MG Not Available Enquire
Nicotine Related Compound F Secondary Standards CS-SS-25770-50MG 5746-86-1 Enquire
Nicotine Related Compound G Secondary Standards CS-SS-25771-50MG 494-52-0 Enquire


Solvent

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Nicotine Polacrilex 20% USP Solvent CS-O-37008 96055-45-7 Enquire


Stable Isotope Reagent

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(±)-Nornicotine-2,3',3',4,5,6-d6 Stable Isotope Reagent CS-C-01431 5746-86-1 (Unlabelled) Enquire
(R,S)-N’-Nitrosonornicotine-13C6 Stable Isotope Reagent CS-T-95750 2726380-44-3 Enquire


Therapeutic

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Methyl nicotinate Therapeutic CS-T-34479 93-60-7 In Stock


Pesticide Standards

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Nicotine Pesticide Standards CS-P-00449 54-11-5 Enquire


Chiral

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(S)-(-)-Anatabine Chiral CS-T-03776 581-49-7 Enquire