Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Nicotine, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Nicotine impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Nicotine-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.
Our Nicotine-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.
Nicotine Related Compounds
Stable Isotopes
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (R)-Anabasine-d4 | Stable Isotopes | CS-T-94109 | 34366-21-7 (Unlabelled) | Enquire |
| (R)-Nicotine-d3 N-β-D-Glucuronide | Stable Isotopes | CS-T-97265 | Not Available | Enquire |
| (R)-N'-Nitrosonornicotine-d4 | Stable Isotopes | CS-P-08860 | 61601-78-3 (Unlabelled) | Enquire |
| (S)-Nicotine-d3 N-b-D-Glucuronide | Stable Isotopes | CS-T-97266 | Not Available | Enquire |
| Isonicotine-d3 | Stable Isotopes | CS-T-98780 | 1346601-08-8 | Enquire |
| Mixture of (R,S)-N-Nitroso Anabasine-d4, rac N’-Nitrosonorn... | Stable Isotopes | CS-T-98765 | Not Available | Enquire |
| N-Formylnornicotine-D4 | Stable Isotopes | CS-T-103948 | 3000-81-5(unlabelled) | Enquire |
| Nicotine-d3 | Stable Isotopes | CS-O-06811 | 69980-24-1 | In Stock |
| Nicotine-d3 N-(4-Deoxy-4,5-didehydro)-b-D-glucuronide | Stable Isotopes | CS-T-97267 | Not Available | Enquire |
| N-Nitrosonornicotine-2,4,5,6-d4(Pyridine-d4) | Stable Isotopes | CS-O-02685 | 66148-19-4 | In Stock |
| rac-N’-Nitrosonornicotine-d4 1-N-Oxide | Stable Isotopes | CS-T-102179 | Not Available | Enquire |
| rac-Nicotine-d4 | Stable Isotopes | CS-T-59260 | 350818-69-8 | In Stock |
| rac-Nicotine-d7 (N-methyl-d3; pyridine-d4) | Stable Isotopes | CS-T-94964 | 1219805-86-3 | In Stock |
| (±)-Nicotine-D3 salicylate | Stable Isotopes | CS-W-00398 | 1173021-00-5 | Enquire |
| (±)-Nornicotine-2,2',3',3',4,5,6-d7 | Stable Isotopes | CS-C-01436 | 5746-86-1 (Unlabelled) | Enquire |
| (2'S)- Nicotine 1-Oxide-d4 | Stable Isotopes | CS-O-34780 | 2820-55-5 | Enquire |
| (2S)-N'-Nitrosonornicotine-d4 | Stable Isotopes | CS-T-59638 | 1426174-36-8 | Enquire |
| (R)-Nornicotine-d4 | Stable Isotopes | CS-T-59754 | 1259761-67-5 | Enquire |
| (R,S)-Nornicotine D4 | Stable Isotopes | CS-T-59755 | 66148-18-3 | Enquire |
| (R,S)-Nornicotine-13C6 | Stable Isotopes | CS-T-97254 | Not Available | Enquire |
| (S)-(-)-Nicotine-15N | Stable Isotopes | CS-T-83661 | 72496-00-5 | Enquire |
| (S)-(-)-Nicotine-d3 | Stable Isotopes | CS-T-94965 | Not Available | Enquire |
| (S)-(-)-Nicotine-d4 | Stable Isotopes | CS-T-59262 | 284685-07-0 | Enquire |
| (S)-Nornicotine D4 | Stable Isotopes | CS-T-59753 | 92761-98-3 | Enquire |
| 5-Methylnicotine D3 | Stable Isotopes | CS-T-58435 | 1190016-33-1 | Enquire |
| Methyl Metanicotine-d3 | Stable Isotopes | CS-T-58403 | 220088-40-4 | Enquire |
| Nicotelline D8 | Stable Isotopes | CS-T-59248 | 1469367-99-4 | Enquire |
| Nicotine-D3-β-D-Glucuronide | Stable Isotopes | CS-T-59175 | 329002-74-6 | Enquire |
| rac N'-Nitrosonornicotine-d4 with (R,S)-N-Nitroso Anabasine-... | Stable Isotopes | CS-T-95148 | Not Available | Enquire |
| rac-Nicotine 13CD3 | Stable Isotopes | CS-T-59259 | 909014-86-4 | Enquire |
| rac-Nicotine 1-Oxide-d4 | Stable Isotopes | CS-O-34782 | 23113-16-8 | Enquire |
| rac-Nicotine-1,2’,3’,4’,5’,6’-13C6 | Stable Isotopes | CS-T-82953 | 1189715-49-8 | Enquire |
| rac-Nicotine-2',3',3'-d3 | Stable Isotopes | CS-T-59258 | 1189681-48-8 | Enquire |
| rac-Nicotine-d3 N-β-D-Glucuronide | Stable Isotopes | CS-T-94966 | Not Available | Enquire |
| rac-trans-Nicotine-1’-oxide-d3 | Stable Isotopes | CS-T-94967 | Not Available | Enquire |
| S-(-)-NICOTINE-D1-(5)-IMINIUM DIPERCHLORATE SALT | Stable Isotopes | CS-T-59176 | 71014-67-0 | Enquire |
API
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (S)-(-)-Nicotine | API | CS-T-36553 | 54-11-5 | In Stock |
| (S)-Anabasine | API | CS-T-48180 | 494-52-0 | In Stock |
| Isonicotinamide | API | CS-T-29786 | 1453-82-3 | In Stock |
| Nicotine Ditartrate Dihydrate | API | CS-O-30688 | 6019-06-3 | In Stock |
| Nicotine lactate | API | CS-ED-41628 | 14474-00-1 | Enquire |
| Nicotine Malate | API | CS-T-96130 | 73057-36-0 | Enquire |
| 2-Methyl Nornicotine | API | CS-T-34709 | 64114-19-8 | Enquire |
| Myosmine | API | CS-M-05066 | 532-12-7 | Enquire |
| Nicotine bitartrate | API | CS-O-30986 | 2624-48-8 | Enquire |
Metabolite
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Nicotinuric Acid | Metabolite | CS-O-03508 | 583-08-4 | In Stock |
| Nudifloramide | Metabolite | CS-O-10017 | 701-44-0 | Enquire |
Impurity
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (+/-)-N-Ethoxycarbonylnornicotine | Impurity | CS-T-54301 | 74245-32-2 | In Stock |
| (1'R,2'S)-Nicotine 1'-Oxide | Impurity | CS-EO-02161 | 51020-67-8 | Enquire |
| (S)-Nicotine-N-oxide | Impurity | CS-EU-00053 | 491-26-9 | In Stock |
| Benzyl nicotinate | Impurity | CS-CG-00214 | 94-44-0 | In Stock |
| Ethyl Nicotinate HCl | Impurity | CS-EO-03725 | 65550-28-9 | Enquire |
| Nicotine Related Compound D | Impurity | CS-O-45829 | 532-12-7 (Freebase) | Enquire |
| Nicotine Related Compound E | Impurity | CS-O-45830 | 491-26-9 (Freebase) | In Stock |
| Rac-Anabasine DiHCl | Impurity | CS-EO-03726 | 143924-48-5 | Enquire |
| (1RS,2S)-Nicotine 1,1-Di-N-Oxide | Impurity | CS-T-59266 | 129547-84-8 | Enquire |
| (2'S)-Nicotine 1-Oxide | Impurity | CS-T-59271 | 2820-55-5 | Enquire |
| (RS)-3-Bromo Nornicotine | Impurity | CS-T-08705 | 71719-06-7 | Enquire |
| (S)-6-Chloro-4-iodonicotine | Impurity | CS-T-11800 | 913264-28-5 | Enquire |
| (S)-6-Chloro-5-iodonicotine | Impurity | CS-T-11801 | 909193-59-5 | Enquire |
| (S)-6-Chloronicotine | Impurity | CS-T-12052 | 112091-17-5 | Enquire |
| (S)-6-Hydroxy Nicotine | Impurity | CS-T-56251 | 10516-09-3 | Enquire |
| (S)-6-Methoxynicotine | Impurity | CS-T-79904 | 224569-41-9 | Enquire |
| (S)-Nornicotine | Impurity | CS-T-59752 | 494-97-3 | Enquire |
| 5-Methyl Nornicotine | Impurity | CS-T-34710 | 126741-11-5 | Enquire |
| 6-Methyl Nornicotine | Impurity | CS-T-34711 | 90872-72-3 | Enquire |
| Isonicotine | Impurity | CS-T-29788 | 92118-22-4 | Enquire |
| N-Boc (RS)-Nornicotine | Impurity | CS-T-07649 | 1076199-53-5 | Enquire |
| N-Ethyl (S)-Nornicotine | Impurity | CS-T-74733 | 5979-92-0 | Enquire |
| R-(R)-Nicotine | Impurity | CS-T-59261 | 25162-00-9 | Enquire |
| rac-trans 3’-Acetylthiomethyl Nicotine | Impurity | CS-T-65218 | 1217716-10-3 | Enquire |
| rac-trans 3’-Hydroxymethylnicotine | Impurity | CS-T-79364 | 71771-91-0 | Enquire |
| rac-trans 3'-Aminomethyl Nicotine | Impurity | CS-T-03016 | 623579-03-3 | Enquire |
| rac-trans 3'-Hydroxymethylnicotine Hemisuccinate | Impurity | CS-T-56226 | 1207282-59-4 | Enquire |
| rac-trans 3'-Hydroxymethylnicotine Hemisuccinate N-Hydroxysu... | Impurity | CS-T-56227 | 1207282-60-7 | Enquire |
| rac-trans 3'-Thiomethyl Nicotine Dihydrochloride | Impurity | CS-T-62022 | 1246820-13-2 | Enquire |
| trans-3′-(Hydroxymethyl)nicotine | Impurity | CS-T-56225 | 33224-02-1 | Enquire |
Intermediate
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (1S,2S)-Nicotine 1-Oxide | Intermediate | CS-T-59177 | 51095-86-4 | In Stock |
| N-Formylnornicotine | Intermediate | CS-T-24746 | 3000-81-5 | In Stock |
Glucuronide
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Nicotinic Acid Acyl-β-D-glucuronide | Glucuronide | CS-T-59280 | 24719-73-1 | Enquire |
| Nicotine-β-D-Glucuronide | Glucuronide | CS-T-59270 | 153536-53-9 | Enquire |
Fine Chemicals
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Nicotine Hydrogen Tartrate | Fine Chemicals | CS-T-82860 | 65-31-6 | Enquire |
| rac-5-Methylnicotine | Fine Chemicals | CS-T-34481 | 82111-06-6 | Enquire |
Nitrosamine
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (2S)-N'-Nitrosonornicotine | Nitrosamine | CS-T-37266 | 16543-55-8 | In Stock |
| (R,S)-N-Nitroso Anabasine HCl salt | Nitrosamine | CS-EO-03727 | 37620-20-5 (Freebase) | Enquire |
| rac-N-Nitroso Nornicotine | Nitrosamine | CS-T-37265 | 80508-23-2 | In Stock |
| (R)-N-Nitrosonornicotine | Nitrosamine | CS-T-37274 | 61601-78-3 | Enquire |
| N’-Nitroso nornicotine-1-N-Oxide | Nitrosamine | CS-O-39105 | Not Available | Enquire |
| N’-Nitrosonornicotine-N-b-D-glucuronide | Nitrosamine | CS-T-83679 | 864071-82-9 | Enquire |
| N'-Nitrosonornicotine-β-D-Glucuronide X Hydrate | Nitrosamine | CS-T-59639 | 350508-25-7 | Enquire |
| N'-Nitrosonornicotine-5-carboxylic Acid | Nitrosamine | CS-T-37272 | 1076199-27-3 | Enquire |
| rac N'-Nitrosonornicotine 5'-Acetate | Nitrosamine | CS-T-37264 | 68743-65-7 | Enquire |
| rac-N-Nitrosonornicotine 1-N-Oxide | Nitrosamine | CS-T-59640 | 1314916-69-2 | Enquire |
Secondary Standards
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Nicotine bitartrate dihydrate | Secondary Standards | CS-SS-25356-500MG | 6019-06-3 | Enquire |
| Nicotine Related Compound A/EP Impurity A | Secondary Standards | CS-SS-25767-50MG | 2743-90-0 | Enquire |
| Nicotine Related Compound B | Secondary Standards | CS-SS-25768-50MG | 487-19-4 | Enquire |
| Nicotine Related Compound C | Secondary Standards | CS-SS-25357-50MG | 486-56-6 | Enquire |
| Nicotine Related Compound D | Secondary Standards | CS-SS-25769-50MG | Not Available | Enquire |
| Nicotine Related Compound F | Secondary Standards | CS-SS-25770-50MG | 5746-86-1 | Enquire |
| Nicotine Related Compound G | Secondary Standards | CS-SS-25771-50MG | 494-52-0 | Enquire |
Solvent
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Nicotine Polacrilex 20% USP | Solvent | CS-O-37008 | 96055-45-7 | Enquire |
Stable Isotope Reagent
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (±)-Nornicotine-2,3',3',4,5,6-d6 | Stable Isotope Reagent | CS-C-01431 | 5746-86-1 (Unlabelled) | Enquire |
| (R,S)-N’-Nitrosonornicotine-13C6 | Stable Isotope Reagent | CS-T-95750 | 2726380-44-3 | Enquire |
Therapeutic
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Methyl nicotinate | Therapeutic | CS-T-34479 | 93-60-7 | In Stock |
Pesticide Standards
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Nicotine | Pesticide Standards | CS-P-00449 | 54-11-5 | Enquire |
Chiral
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (S)-(-)-Anatabine | Chiral | CS-T-03776 | 581-49-7 | Enquire |