Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Nicotine, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Nicotine impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Nicotine-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.
Our Nicotine-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.
Nicotine Related Compounds
Stable Isotopes
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (2'S)- Nicotine 1-Oxide-d4 | Stable Isotopes | CS-O-34780 | 2820-55-5 | Enquire |
| (2S)-N'-Nitrosonornicotine-d4 | Stable Isotopes | CS-T-59638 | 1426174-36-8 | Enquire |
| (±)-Nicotine-d7 (N-methyl-d3; pyridine-d4) | Stable Isotopes | CS-T-94964 | 1219805-86-3 | In Stock |
| (R)-Nicotine-d3 N-?-D-Glucuronide | Stable Isotopes | CS-T-97265 | Not Available | Enquire |
| (R)-N'-Nitrosonornicotine-d4 | Stable Isotopes | CS-P-08860 | 61601-78-3 (Unlabelled) | Enquire |
| (R)-Nornicotine-d4 | Stable Isotopes | CS-T-59754 | 1259761-67-5 | Enquire |
| (R,S)-Nornicotine D4 | Stable Isotopes | CS-T-59755 | 66148-18-3 | Enquire |
| (S)-(-)-Nicotine-15N | Stable Isotopes | CS-T-83661 | 72496-00-5 | Enquire |
| (S)-(-)-Nicotine-d4 | Stable Isotopes | CS-T-59262 | 284685-07-0 | Enquire |
| (S)-Nicotine-d3 N-b-D-Glucuronide | Stable Isotopes | CS-T-97266 | Not Available | Enquire |
| (S)-Nornicotine D4 | Stable Isotopes | CS-T-59753 | 92761-98-3 | Enquire |
| 5-Methylnicotine D3 | Stable Isotopes | CS-T-58435 | 1190016-33-1 | Enquire |
| Isonicotine-d3 | Stable Isotopes | CS-T-98780 | 1346601-08-8 | Enquire |
| Methyl Metanicotine-d3 | Stable Isotopes | CS-T-58403 | 220088-40-4 | Enquire |
| Mixture of (R,S)-N-Nitroso Anabasine-d4, rac N’-Nitrosonorn... | Stable Isotopes | CS-T-98765 | Not Available | Enquire |
| N-Formylnornicotine-D4 | Stable Isotopes | CS-T-103948 | 3000-81-5(unlabelled) | Enquire |
| Nicotine-d3 | Stable Isotopes | CS-O-06811 | 69980-24-1 | In Stock |
| Nicotine-d3 N-(4-Deoxy-4,5-didehydro)-b-D-glucuronide | Stable Isotopes | CS-T-97267 | Not Available | Enquire |
| Nicotine-D3-β-D-Glucuronide | Stable Isotopes | CS-T-59175 | 329002-74-6 | Enquire |
| N-Nitrosonornicotine-2 | Stable Isotopes | CS-O-02685 | 66148-19-4 | In Stock |
| rac-N’-Nitrosonornicotine-d4 1-N-Oxide | Stable Isotopes | CS-T-102179 | Not Available | Enquire |
| rac-Nicotine 13CD3 | Stable Isotopes | CS-T-59259 | 909014-86-4 | Enquire |
| rac-Nicotine 1-Oxide-d4 | Stable Isotopes | CS-O-34782 | 23113-16-8 | Enquire |
| rac-Nicotine-1,2’,3’,4’,5’,6’-13C6 | Stable Isotopes | CS-T-82953 | 1189715-49-8 | Enquire |
| rac-Nicotine-2',3',3'-d3 | Stable Isotopes | CS-T-59258 | 1189681-48-8 | Enquire |
| rac-Nicotine-d4 | Stable Isotopes | CS-T-59260 | 350818-69-8 | In Stock |
| S-(-)-NICOTINE-D1-(5)-IMINIUM DIPERCHLORATE SALT | Stable Isotopes | CS-T-59176 | 71014-67-0 | Enquire |
API Standards
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (S)-(-)-Nicotine | API Standards | CS-T-36553 | 54-11-5 | In Stock |
| 2-Methyl Nornicotine | API Standards | CS-T-34709 | 64114-19-8 | Enquire |
| Nicotine bitartrate | API Standards | CS-O-30986 | 2624-48-8 | Enquire |
| Nicotine Ditartrate Dihydrate | API Standards | CS-O-30688 | 6019-06-3 | In Stock |
| Nicotine lactate | API Standards | CS-ED-41628 | 14474-00-1 | Enquire |
| Nicotine Malate | API Standards | CS-T-96130 | 73057-36-0 | Enquire |
Metabolites
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Nicotinuric Acid | Metabolites | CS-O-03508 | 583-08-4 | In Stock |
Impurities
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (+/-)-N-Ethoxycarbonylnornicotine | Impurities | CS-T-54301 | 74245-32-2 | In Stock |
| (1'R,2'S)-Nicotine 1'-Oxide | Impurities | CS-EO-02161 | 51020-67-8 | Enquire |
| (1RS,2S)-Nicotine 1,1-Di-N-Oxide | Impurities | CS-T-59266 | 129547-84-8 | Enquire |
| (2'S)-Nicotine 1-Oxide | Impurities | CS-T-59271 | 2820-55-5 | Enquire |
| (R)-N-Nitrosonornicotine | Impurities | CS-T-37274 | 61601-78-3 | Enquire |
| (R,S)-N-Nitroso Anabasine HCl salt | Impurities | CS-EO-03727 | 37620-20-5 (Freebase) | Enquire |
| (RS)-3-Bromo Nornicotine | Impurities | CS-T-08705 | 71719-06-7 | Enquire |
| (RS)-N-Ethyl Nornicotine | Impurities | CS-T-54540 | 86900-39-2 | Enquire |
| (S)-6-Chloro-4-iodonicotine | Impurities | CS-T-11800 | 913264-28-5 | Enquire |
| (S)-6-Chloro-5-iodonicotine | Impurities | CS-T-11801 | 909193-59-5 | Enquire |
| (S)-6-Chloronicotine | Impurities | CS-T-12052 | 112091-17-5 | Enquire |
| (S)-6-Hydroxy Nicotine | Impurities | CS-T-56251 | 10516-09-3 | Enquire |
| (S)-6-Methoxynicotine | Impurities | CS-T-79904 | 224569-41-9 | Enquire |
| (S)-Nicotine-N-oxide | Impurities | CS-EU-00053 | 491-26-9 | In Stock |
| (S)-Nornicotine | Impurities | CS-T-59752 | 494-97-3 | Enquire |
| 5-Methyl Nornicotine | Impurities | CS-T-34710 | 126741-11-5 | Enquire |
| 6-Methyl Nornicotine | Impurities | CS-T-34711 | 90872-72-3 | Enquire |
| Benzyl nicotinate | Impurities | CS-CG-00214 | 94-44-0 | In Stock |
| Isonicotine | Impurities | CS-T-29788 | 92118-22-4 | Enquire |
| N’-Nitroso nornicotine-1-N-Oxide | Impurities | CS-O-39105 | Not Available | Enquire |
| N-Boc (RS)-Nornicotine | Impurities | CS-T-07649 | 1076199-53-5 | Enquire |
| N-Ethyl (S)-Nornicotine | Impurities | CS-T-74733 | 5979-92-0 | Enquire |
| Nicotine Related Compound D | Impurities | CS-O-45829 | 532-12-7 (Freebase) | Enquire |
| Nicotine Related Compound E | Impurities | CS-O-45830 | 491-26-9 (Freebase) | In Stock |
| N'-Nitrosonornicotine-5-carboxylic Acid | Impurities | CS-T-37272 | 1076199-27-3 | Enquire |
| R-(R)-Nicotine | Impurities | CS-T-59261 | 25162-00-9 | Enquire |
| rac N'-Nitrosonornicotine 5'-Acetate | Impurities | CS-T-37264 | 68743-65-7 | Enquire |
| rac-N-Nitroso Nornicotine | Impurities | CS-T-37265 | 80508-23-2 | In Stock |
| rac-N-Nitrosonornicotine 1-N-Oxide | Impurities | CS-T-59640 | 1314916-69-2 | Enquire |
| rac-trans 3’-Acetylthiomethyl Nicotine | Impurities | CS-T-65218 | 1217716-10-3 | Enquire |
| rac-trans 3’-Hydroxymethylnicotine | Impurities | CS-T-79364 | 71771-91-0 | Enquire |
| rac-trans 3'-Aminomethyl Nicotine | Impurities | CS-T-03016 | 623579-03-3 | Enquire |
| rac-trans 3'-Hydroxymethylnicotine Hemisuccinate | Impurities | CS-T-56226 | 1207282-59-4 | Enquire |
| rac-trans 3'-Hydroxymethylnicotine Hemisuccinate N-Hydroxysu... | Impurities | CS-T-56227 | 1207282-60-7 | Enquire |
| rac-trans 3'-Thiomethyl Nicotine Dihydrochloride | Impurities | CS-T-62022 | 1246820-13-2 | Enquire |
| trans-3′-(Hydroxymethyl)nicotine | Impurities | CS-T-56225 | 33224-02-1 | Enquire |
EP Standards
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Nicotine for system suitability (Y0001023) | EP Standards | CS-EG-02880 | 65-31-6 | Enquire |
Intermediates
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (-)-Nicotine Hemisulfate Salt | Intermediates | CS-T-83638 | 65-30-5 | Enquire |
| (+/-)-2-Methylnicotine | Intermediates | CS-T-34480 | 64114-31-4 | Enquire |
| (1S,2S)-Nicotine 1-Oxide | Intermediates | CS-T-59177 | 51095-86-4 | In Stock |
| (R)-Nornicotine | Intermediates | CS-T-82951 | 7076-23-5 | Enquire |
| (RS)-Nornicotine | Intermediates | CS-T-37586 | 5746-86-1 | In Stock |
| (S)-(-)-Nicotine Mono Tartrate | Intermediates | CS-T-59263 | 6550-19-2 | Enquire |
| (S)-6-Methylnicotine | Intermediates | CS-T-80921 | 13270-56-9 | Enquire |
| 5-Ethynyl Nicotine | Intermediates | CS-T-23273 | 179120-92-4 | Enquire |
| 5-Triisopropylsilyl-ethynyl (S)-(-)-Nicotine | Intermediates | CS-T-45514 | 916046-39-4 | Enquire |
| Metanicotine | Intermediates | CS-T-58402 | 15585-43-0 | Enquire |
| N-Formylnornicotine | Intermediates | CS-T-24746 | 3000-81-5 | In Stock |
| Nicotine Salicylate | Intermediates | CS-T-59272 | 29790-52-1 | Enquire |
| o-Nicotine | Intermediates | CS-T-59264 | 23950-04-1 | Enquire |
| R-(+)-Nicotine Di-p-toluoyl-D-tartrate Salt | Intermediates | CS-T-59268 | 68935-27-3 | Enquire |
| rac 2-Chloro Nicotine | Intermediates | CS-T-72159 | 871894-35-8 | Enquire |
| rac-2-Amino Nicotine | Intermediates | CS-T-03118 | 32726-84-4 | Enquire |
| rac-2-Hydroxy Nicotine | Intermediates | CS-T-28293 | 2055-24-5 | Enquire |
| rac-Nicotine | Intermediates | CS-T-59257 | 22083-74-5 | Enquire |
| rac-Nicotine 1-Oxide | Intermediates | CS-T-83116 | 23113-16-8 | Enquire |
| rac-ortho-Nicotine Diperchlorate | Intermediates | CS-T-59267 | 147663-86-3 | Enquire |
| S-(-)-Nicotine Di-p-Toluoyl-D-Tartrate Salt | Intermediates | CS-T-59269 | 68935-26-2 | Enquire |
| S-(-)-Nicotine-5-carboxaldehyde | Intermediates | CS-T-59265 | 852238-97-2 | Enquire |
Glucuronides
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| N’-Nitrosonornicotine-N-b-D-glucuronide | Glucuronides | CS-T-83679 | 864071-82-9 | Enquire |
| Nicotine-β-D-Glucuronide | Glucuronides | CS-T-59270 | 153536-53-9 | Enquire |
| N'-Nitrosonornicotine-β-D-Glucuronide X Hydrate | Glucuronides | CS-T-59639 | 350508-25-7 | Enquire |
Fine Chemicals
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Nicotine Hydrogen Tartrate | Fine Chemicals | CS-T-82860 | 65-31-6 | Enquire |
| rac-5-Methylnicotine | Fine Chemicals | CS-T-34481 | 82111-06-6 | Enquire |
Pesticide Standards
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Nicotine | Pesticide Standards | CS-P-00449 | 54-11-5 | Enquire |