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Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Nintedanib, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Nintedanib impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Nintedanib-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.

Nintedanib Related Compounds

Stable Isotopes

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Nintedanib Demethyl-O-glucuronic Acid-d3 Stable Isotopes CS-T-98419 Not Available Enquire
Nintedanib Demethyl-O-β-D-glucuronic Acid Methyl Ester 2,3,4... Stable Isotopes CS-T-98418 Not Available Enquire
Nintedanib Demethyl-O-β-D-glucuronic Acid Methyl Ester-D3 Stable Isotopes CS-T-99944 Not Available Enquire
Nintedanib-13C,d3 Stable Isotopes CS-O-14348 656247-17-5 (Unlabeled) In Stock
Nintedanib-D3 Stable Isotopes CS-EO-02387 1624587-84-3 Enquire
Nintedanib-d8 (Intedanib-d8) Stable Isotopes CS-O-16500 1624587-87-6 Enquire


API

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Nintedanib API CS-O-11187 656247-17-5 In Stock


Metabolite

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
N-Desmethyl Nintedanib-5-carboxylate Metabolite CS-O-53330 ---- Enquire
Nintedanib Carboxylic Acid Metabolite CS-P-01888 894783-71-2 In Stock
Nintedanib Metabolite M2 Metabolite CS-O-16504 1352789-50-4 In Stock
Nintedanib N-Oxide trifluoroacetate Metabolite CS-O-47299 2734666-06-7 (Freebase) Enquire


Impurity

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(Z)-3-(1-hydroxypropylidene)-2-oxo-1-propionylindoline-6-car... Impurity CS-O-44850 Not Available Enquire
(Z)-4-(2-((4-(((6-(methoxycarbonyl)-2-oxoindolin-3-ylidene)(... Impurity CS-O-37559 1799894-54-4 Enquire
(Z)-methyl 3- (1-methoxypropylidene)-2-oxo-1-propionylindoli... Impurity CS-O-44851 Not Available Enquire
2-Chloro-N-Methyl-N-(4-Nitrophenyl)Acetamide Impurity CS-O-16027 2653-16-9 In Stock
3-(Methoxy-phenyl-methylene)2-oxo-1-propionyl-2,3-dihydro-1H... Impurity CS-O-44852 Not Available Enquire
Dimethyl 2-(4-(methoxycarbonyl)-2-nitrophenyl)malonate Impurity CS-O-16116 1160293-27-5 In Stock
Methyl (Z)-3-((4-(2-((4-((((Z)-6-(methoxycarbonyl)-2-oxoindo... Impurity CS-O-59167 ---- Enquire
N1,N4-Bis(4-nitrophenyl)-1,4-piperazinediacetamide Impurity CS-BX-02882 294193-70-7 In Stock
N-Acetyl Nintedanib Impurity CS-O-32878 2380229-45-6 Enquire
N-Desmethyl Nintedanib Impurity CS-O-45337 334951-61-0 In Stock
Nintedanib 4-Hydroxyphenyl Analog Impurity CS-O-54362 2519501-85-8 Enquire
Nintedanib Acetamide Impurity CS-O-16016 262368-25-2 In Stock
Nintedanib acetyl impurity Impurity CS-O-32877 1139458-48-2 In Stock
Nintedanib E-isomer (Intedanib E-isomer) Impurity CS-P-05581 Not Available Enquire
Nintedanib Esylate N-Oxide Impurity Impurity CS-O-56488 ---- Enquire
Nintedanib Ethoxy Enolindole Impurity CS-O-34295 656247-19-7 Enquire
Nintedanib Ethoxyenolindole Impurity CS-O-45336 2095628-43-4 Enquire
Nintedanib Ethyl Ester Impurity CS-O-46562 Not Available Enquire
Nintedanib Impurity 12 Impurity CS-O-56593 ---- Enquire
Nintedanib Impurity 13 Impurity CS-O-56594 ---- Enquire
Nintedanib Impurity 16 Impurity CS-O-56595 ---- Enquire
Nintedanib Impurity 17 Impurity CS-O-56596 ---- Enquire
Nintedanib Impurity 18 Impurity CS-O-56597 2936656-87-8 Enquire
Nintedanib Impurity 22 Impurity CS-O-42675 2410284-89-6 In Stock
Nintedanib Impurity 25 Impurity CS-EO-00266 ---- Enquire
Nintedanib Impurity 26 Impurity CS-EO-01297 Not Available In Stock
Nintedanib Impurity 28 Impurity CS-SN-00148 2410649-54-4 In Stock
Nintedanib Impurity 4 Impurity CS-P-01886 1987887-92-2 Enquire
Nintedanib Impurity 4 TFA salt Impurity CS-O-53559 1987887-92-2(free base) In Stock
Nintedanib Impurity 43 Impurity CS-EO-02111 856844-57-0 In Stock
Nintedanib Impurity 5 Impurity CS-P-01887 Not Available In Stock
Nintedanib Impurity 53 Impurity CS-EO-02746 676326-36-6 In Stock
Nintedanib Impurity 54 Impurity CS-EO-02747 1175365-43-1 Enquire
Nintedanib Impurity 63 Impurity CS-P-09212 2243384-71-4 Enquire
Nintedanib Impurity 8 Impurity CS-P-01890 2093243-16-2 Enquire
Nintedanib Impurity B Impurity CS-P-01876 894783-61-0 In Stock
Nintedanib Impurity E Impurity CS-P-01879 1610881-60-1 Enquire
Nintedanib Impurity H Impurity CS-P-01882 Not Available Enquire
Nintedanib Impurity H Impurity CS-O-46561 2734676-68-5 Enquire
Nintedanib Methyl impurity Impurity CS-O-32876 2734410-06-9 Enquire
Nintedanib N, N-Dimethyl amine impurity Impurity CS-O-45335 2454314-41-9 In Stock
Nintedanib N-Acetyl Impurity Impurity CS-EO-01565 2130844-77-6 Enquire
Nintedanib N-Acyl methoxyenolindole Impurity CS-O-60139 1253769-13-9 Enquire
Nintedanib N-desmethyl N-ethyl Impurity Impurity CS-O-41234 ---- In Stock
Nintedanib N-Oxide Impurity 1 Impurity CS-O-41346 ---- In Stock
Nintedanib N-oxide Impurity H Impurity CS-O-53558 ---- Enquire
Nintedanib Piperazine Dimer Acetyl Impurity Impurity CS-O-56489 2410649-55-5 Enquire
Nintedanib Piperazine Dimer Impurity Impurity CS-EO-01904 2410284-90-9 Enquire
Nintedanib Piperazinyl-N4-oxide Impurity CS-O-35713 3029792-02-4 Enquire
N-Propanoyl Nintedanib Impurity CS-O-45007 2097505-01-4 Enquire
(3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H... Impurity CS-T-64313 1168152-06-4 Enquire
methyl (Z)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carb... Impurity CS-O-36824 1438271-13-6 Enquire
Nintedanib DP6 Impurity CS-O-41347 Not Available Enquire
Nintedanib DP7 Impurity CS-O-41348 Not Available Enquire
Nintedanib DP8 Impurity CS-O-41349 Not Available Enquire
Nintedanib E-Isomer Impurity CS-EO-01918 1160294-26-7 (EZ) Enquire
Nintedanib Impurity 1 Impurity CS-P-01883 Not Available Enquire
Nintedanib Impurity 15 Impurity CS-O-42220 1027407-75-5 Enquire
Nintedanib Impurity 2 Impurity CS-P-01884 1174335-83-1 Enquire
Nintedanib Impurity 24 Impurity CS-EO-01296 1139455-52-9 Enquire
Nintedanib Impurity 3 Impurity CS-P-01885 1168150-46-6 Enquire
Nintedanib Impurity 7 Impurity CS-P-01889 Not Available Enquire
Nintedanib Impurity 9 Impurity CS-P-01891 Not Available Enquire
Nintedanib Impurity A Impurity CS-P-01875 Not Available Enquire
Nintedanib Impurity C Impurity CS-P-01877 Not Available Enquire
Nintedanib Impurity D Impurity CS-P-01878 Not Available Enquire
Nintedanib Impurity F Impurity CS-P-01880 Not Available Enquire
Nintedanib Impurity G Impurity CS-P-01881 Not Available Enquire
Nintedanib N,N,-Dimethyl Aniline Impurity Impurity CS-O-16114 Not Available Enquire
Nintedanib N-Methyl Aniline Impurity Impurity CS-O-16113 Not Available Enquire


Intermediate

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Methyl Ethanesulfonate Intermediate CS-T-81674 1912-28-3 In Stock
Nintedanib Esylate Intermediate CS-T-83804 656247-18-6 In Stock
N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetami... Intermediate CS-T-80913 1139453-98-7 Enquire


Glucuronide

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Nintedanib N-Glucuronide-1 Glucuronide CS-P-05589 ---- Enquire
Nintedanib N-Glucuronide-2 Glucuronide CS-O-56600 ---- Enquire


Fine Chemicals

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
6-Carboxyoxindole Fine Chemicals CS-T-71119 334952-09-9 Enquire
N-(2-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetami... Fine Chemicals CS-O-36110 2117628-65-4 Enquire
N-(4-Aminophenyl)-2-chloro-N-methylAcetamide Fine Chemicals CS-ZH-26783 855860-75-2 Enquire


Nitrosamine

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
N,N-Di desmethyl N-Nitroso Nintedanib 4-Nitrophenyl Impurity Nitrosamine CS-O-52356 Not Available In Stock
N,N-Di desmethyl N-Nitroso Nintedanib Aniline Impurity Nitrosamine CS-O-52355 Not Available In Stock
Nintedanib 4-Nitrophenyl 2-(4-Nitroso) Nitrosamine CS-O-46381 2490403-92-2 In Stock
Nintedanib Nitroso Impurity 2 Nitrosamine CS-O-45388 Not Available Enquire
N-Nitroso Nintedanib Nitrosamine CS-O-38910 ---- Discontinued
N-Nitroso Nintedanib Impurity-4 Nitrosamine CS-O-53609 Not Available In Stock
N-nitrosoacetamido-Nintedanib Nitrosamine CS-O-41056 Not Available Enquire
N-nitroso-N-desmethyl nintedanib Nitrosamine CS-O-41055 ---- In Stock


Analytical Standard

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
N-Nitroso Nintedanib Analytical Standard CS-O-38910-10MG ---- Enquire
N-nitroso-nintedanib-100 PPM in Acetonitrile Analytical Standard CS-O-38910-1.5ML ---- Enquire