Docetaxel - Impurity E

Docetaxel - Impurity E

32981-86-5

CS-O-31076

38229010

Can be shipped from India, Canada and USA

C²⁹H³⁶O₁₀

544.59

Consulte la MSDS para obtener información completa.

Consulte la MSDS para obtener información precisa.

Docetaxel - Impurity E is supplied with detailed characterization data compliant with regulatory guideline. Docetaxel - Impurity E can be used for analytical method development, method validation (AMV), Quality Control (QC) application for Abbreviated New Drug Application (ANDA), or during commercial production of Baccatin.

"Impurity in commerial preparation of Baccatin.;Impurity in commercial preparations of Baccatin. Cabazitaxel intermediate. 10-Deacetylbaccatin III is an inhibitor of microtubule assembly (IC50s = 23 and 0.9 ?M for porcine brain and Physaram microtubules, respectively) found in T. baccata extracts.1 It is a precursor in the semisynthetic synthesis of paclitaxel (Item No. 10461) and other semisynthetic toxoids.2 10-Deacetylbaccatin III also selectively inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM), while having no effect on macrophage morphology.3"

Docetaxel - Impurity E

"Impurity in commerial preparation of Baccatin.;Impurity in commercial preparations of Baccatin. Cabazitaxel intermediate. 10-Deacetylbaccatin III is an inhibitor of microtubule assembly (IC50s = 23 and 0.9 ?M for porcine brain and Physaram microtubules, respectively) found in T. baccata extracts.1 It is a precursor in the semisynthetic synthesis of paclitaxel (Item No. 10461) and other semisynthetic toxoids.2 10-Deacetylbaccatin III also selectively inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM), while having no effect on macrophage morphology.3"

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