Bisoprolol Phenol Impurity

Product Name Bisoprolol Phenol Impurity
Alternate Names Bisoprolol Impurities, Impurities of Bisoprolol
CAT No. CS-P-00061
CAS No. 62340-37-8
Category Impurities
Stock IN-Stock
Mol. Wt. 225.28 g/mol
Mol. For. C12H19NO3
Hazardous This is a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Bisoprolol
Therapeutic Anti-Hypertensives
Smileys CC(C)NCC(COC1=CC=C(C=C1)O)O
Canonical Smiles CC(C)NCC(COC1=CC=C(C=C1)O)O
InchIKey ADUKCCWBEDSMEB-UHFFFAOYSA-N
Inchl InChI=1S/C12H19NO3/c1-9(2)13-7-11(15)8-16-12-5-3-10(14)4-6-12/h3-6,9,11,13-15H,7-8H2,1-2H3
IUPAC 4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenol
Controlled No
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Bisoprolol is a beta-blocker used to treat high blood pressure, angina, and congestive heart failure. However, during its manufacturing process, a phenol impurity may be formed. This impurity is a result of the reaction of bisoprolol with phenol during the synthesis process. Phenol is a toxic and corrosive substance that can be harmful to the environment and humans alike. Bisoprolol phenol impurity can cause skin and eye irritation, respiratory problems, and other health issues. Therefore, the presence of this impurity in bisoprolol must be monitored and controlled to ensure the safety of patients taking this medication. The chemical composition of bisoprolol phenol impurity includes a benzene ring, a hydroxyl group (-OH), and a nitrogen atom. This impurity has a molecular weight of 343.4 g/mol and a boiling point of 249°C. It is soluble in water and organic solvents such as methanol and ethanol. Several analytical methods can be used to detect and quantify bisoprolol phenol impurity, including high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and Fourier transform infrared spectroscopy (FTIR). Manufacturers of bisoprolol must adhere to strict regulations in order to ensure the purity of the medication and minimize the presence of this impurity.

Related Compounds

Bisoprolol EP Impurity F | Bisoprolol EP Impurity B Hemifumarate (Bisoprolol n-Propyl Derivative Hemifumarate) | Bisoprolol O-Phosphate | Bisoprolol EP Impurity D (TFA) | Bisoprolol EP Impurity T | Bisoprolol EP Impurity B | Des O-isopropyl Bisoprolol | N-Acetyl Bisoprolol | R-(+)-Bisoprolol Fumarate | Bisoprolol Impurity 3 | Bisoprolol Benzylalcohol | Bisoprolol Alcohol Impurity | Bisoprolol EP Impurity L hydrochloride | Bisoprolol EP Impurity A | Bisoprolol Epoxide Impurity | Bisoprolol Impurity 11 (mixture of isomers) | Bisoprolol glycerol diether impurity | Bisoprolol Diene Impurity | Bisoprolol EP Impurity J | Bisoprolol EP Impurity C | Bisoprolol EP Impurity N | Bisoprolol Ester Impurity | Bisoprolol EP Impurity M | N-Desisopropyl-N-formyl Bisoprolol | Bisoprolol EP Impurity G fumarate salt | Bisoprolol Impurity 4 | Bisoprolol Dimer | Bisoprolol EP Impurity Q | Dehydro Bisoprolol | Bisoprolol Carboxylic Acid Impurity | Bisoprolol EP Impurity D | Dehydro Bisoprolol Hemifumarate | Bisoprolol Impurity | Bisoprolol N-Methyl Impurity | Bisoprolol EP Impurity R | Bisoprolol Related Compound D | N-Formylbisoprolol | Bisoprolol benzyl alcohol fumarate | Bisoprolol EP Impurity F Butenedioic acid salt |

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