Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Abacavir-d4 Hydrochloride, 1346605-40-0
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Refer MSDS for complete information
Abacavir-d4 Hydrochloride is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
We are committed to offering products of the highest quality in order to meet the needs of our customers, and have elaborate systems in
place to ensure that material specifications, their certification and all handling and storage conditions are communicated at the time of
material handover.
We have invested in the highest quality packaging materials and use international logistics partners to service our customers. While all
possible precautions have been taken to deliver the required product(s), there may be some rare situations when our product does not
meet your requirements. Should that arise, please contact us with your concerns and we will endeavour to address them on a priority
basis. If there is no other option, we will either replace your product(s) or issue a refund or account credit, whichever you prefer.
If there is an issue with one or more of our products, our policy is that it must be reported to us within 45 days of your receiving shipment.
While we will always address product issues after the 45 day return window has passed, we cannot issue a refund or account credit. As
always, we appreciate your support.
Abacavir-d4 Hydrochloride usage and description
Abacavir-d4 HCl is a modified form of the anti-viral drug Abacavir, which is used in the treatment of HIV-1 infection. The abbreviation “d4” indicates that the compound contains four deuterium atoms, which are heavy isotopes of hydrogen. This modification is made to Abacavir in order to create a stable isotope-labeled version of the drug, which can be used in pharmacokinetic studies to understand its metabolism and excretion.
Abacavir-d4 HCl is administered orally in the form of tablets, which are taken with or without food. The recommended adult dose is 600 mg daily, divided into two or three doses. The drug is absorbed rapidly from the gastrointestinal tract and reaches peak plasma concentrations within 1.5 hours. It is metabolized in the liver and excreted in the urine and feces.
The exact mechanism of action of Abacavir-d4 HCl is not fully understood, but it is thought to inhibit the activity of the reverse transcriptase enzyme, which is essential for the replication of the HIV virus. The drug is also known to have a low genetic barrier to resistance, meaning that HIV can quickly develop resistance to Abacavir-d4 HCl if it is not used in combination with other anti-retroviral drugs.
In terms of chemical information, Abacavir-d4 HCl has the molecular formula C14H13D4N5O3·HCl and a molecular weight of 342.82 g/mol. It is a white to off-white crystalline powder that is highly soluble in water and slightly soluble in ethanol. The drug should be stored in a cool, dry place and protected from light.
