Therapeutic Uses
Anti-Cancer / Oncology
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
3-(((2R,3S)-2-((R)-1-(3,5-bis(trifuoromethyl)phenyl)ethoxy)-3-(4-fuorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
Yes -Refer MSDS for accurate information
Aprepitant-d4 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
We are committed to offering products of the highest quality in order to meet the needs of our customers, and have elaborate systems in
place to ensure that material specifications, their certification and all handling and storage conditions are communicated at the time of
material handover.
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possible precautions have been taken to deliver the required product(s), there may be some rare situations when our product does not
meet your requirements. Should that arise, please contact us with your concerns and we will endeavour to address them on a priority
basis. If there is no other option, we will either replace your product(s) or issue a refund or account credit, whichever you prefer.
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While we will always address product issues after the 45 day return window has passed, we cannot issue a refund or account credit. As
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Aprepitant-d4 usage and description
Aprepitant D4 is a deuterated form of Aprepitant, which is a neurokinin-1 (NK1) receptor antagonist used in the prevention of chemotherapy-induced nausea and vomiting. It is a selective antagonist of the NK1 receptor, which plays a crucial role in the emetic response to chemotherapy. Aprepitant D4 is used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic chemotherapy.
The chemical formula of Aprepitant D4 is C23H22D4F6N4O, and its molecular weight is 494.51 g/mol. It is a white to off-white crystalline powder that is insoluble in water but soluble in methanol and ethanol. The deuterated form of Aprepitant is used in pharmacokinetic studies to determine the metabolic pathways of the drug and its active metabolites.
Aprepitant D4 is metabolized primarily by CYP3A4 and is excreted in the feces and urine. It has a half-life of approximately 12 hours and reaches maximum plasma concentrations within 3 hours of oral administration. The recommended dosage of Aprepitant D4 varies depending on the type of chemotherapy and the patient's medical history.
In conclusion, Aprepitant D4 is a useful tool in pharmacokinetic research and is commonly used in combination with other antiemetic agents for the prevention of chemotherapy-induced nausea and vomiting. Its selective antagonism of the NK1 receptor makes it an effective treatment option for patients undergoing highly emetogenic chemotherapy.
