M.F.
CโโHโโDโFโNโOโ
Therapeutic Uses
Anti-Cancer / Oncology
Storage Condition
Store at refrigerator (2-8ยฐC) for long term storage
Synonyms
3-(((2R,3S)-2-((R)-1-(3,5-bis(trifuoromethyl)phenyl)ethoxy)-3-(4-fuorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
Yes -Refer MSDS for accurate information
Aprepitant-d4 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
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Aprepitant-d4 usage and description
Aprepitant D4 is a deuterated form of Aprepitant, which is a neurokinin-1 (NK1) receptor antagonist used in the prevention of chemotherapy-induced nausea and vomiting. It is a selective antagonist of the NK1 receptor, which plays a crucial role in the emetic response to chemotherapy. Aprepitant D4 is used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic chemotherapy.
The chemical formula of Aprepitant D4 is C23H22D4F6N4O, and its molecular weight is 494.51 g/mol. It is a white to off-white crystalline powder that is insoluble in water but soluble in methanol and ethanol. The deuterated form of Aprepitant is used in pharmacokinetic studies to determine the metabolic pathways of the drug and its active metabolites.
Aprepitant D4 is metabolized primarily by CYP3A4 and is excreted in the feces and urine. It has a half-life of approximately 12 hours and reaches maximum plasma concentrations within 3 hours of oral administration. The recommended dosage of Aprepitant D4 varies depending on the type of chemotherapy and the patient's medical history.
In conclusion, Aprepitant D4 is a useful tool in pharmacokinetic research and is commonly used in combination with other antiemetic agents for the prevention of chemotherapy-induced nausea and vomiting. Its selective antagonism of the NK1 receptor makes it an effective treatment option for patients undergoing highly emetogenic chemotherapy.