Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
[2-(4'-chloro-2,3,4,5-tetrahydro-[1,1'-biphenyl]-4-yl)-3-hydroxynaphthalene-1,4-dione]
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90 %
Hazard Compound
No -Refer MSDS for accurate information
Didehydro Atovaquone is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
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Didehydro Atovaquone usage and description
Didehydro Atovaquone is a drug used to treat malaria caused by Plasmodium falciparum. It is a synthetic compound that inhibits the mitochondrial electron transport chain in the malaria parasite, leading to the death of the parasite. It is usually administered orally in combination with proguanil, another antimalarial drug, to increase its efficacy and reduce the risk of resistance.
Chemically, Didehydro Atovaquone is a derivative of Atovaquone, a hydroxynaphthoquinone compound. The addition of a second hydroxy group to Atovaquone creates the didehydro compound. The molecular formula of Didehydro Atovaquone is C22H19ClO5, and it has a molecular weight of 406.84 g/mol.
The drug is metabolized in the liver and excreted in the feces. It has a half-life of about 50 hours, which allows for once-daily dosing. It is generally well-tolerated, with the most common side effects being gastrointestinal discomfort and headache.
Didehydro Atovaquone is an important weapon in the fight against malaria, a disease that affects millions of people worldwide, particularly in sub-Saharan Africa. Its efficacy, safety, and ease of administration make it a valuable tool in malaria control programs. However, its use should be accompanied by measures to prevent the spread of malaria, such as insecticide-treated bed nets and indoor residual spraying.
