Product Detail
4-Hydroxy-Teriflunomide
Teriflunomide Metabolite
Stock Status: In Stock
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For Research & Analytical Purposes. Not for Personal use.
Category
Metabolite
API Family
Teriflunomide
Storage
2-8°C
Hazard Information
Refer MSDS for complete information.
4-Hydroxy-Teriflunomide Product Information
4-Hydroxy-Teriflunomide is listed under Metabolite. It is associated with Teriflunomide and is intended for analytical research, quality control and pharmaceutical reference standard applications. The product is supplied by Clearsynth under CAT No. CS-T-28773.
Clearsynth provides this compound for research and analytical use, with product information including CAS number, molecular formula, molecular weight, stock enquiry details and supporting documentation.
Technical Data
Product Name
4-Hydroxy-Teriflunomide
CAS No.
1058722-45-4
CAT No.
CS-T-28773
Molecular Formula
C12H9F3N2O3
Molecular Weight
286.21
Category
API Family
Storage Condition
2-8°C
SMILES
O=C(NC1=CC=C(C(F)(F)F)C=C1)/C(C#N)=C(O)/CO
IUPAC Name
(2Z)-2-Cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Hazard Compound
Refer MSDS for complete information.
Description
Overview
"4-Hydroxy-Teriflunomide is a metabolite of Leflunomide , an immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index)."
Synonyms
(2Z)-2-Cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Application Notes
"4-Hydroxy-Teriflunomide is a metabolite of Leflunomide , an immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index)."
References
"Vrenken, T,, et al,: J, Hepatol,, 49, 799 (2008), Mazzucco, G,, et al,: Clin, Nephrol,, 70, 163 (2008), Davies, M,, et al,: J, Med, Chem,, 52, 2683 (2009),"
