Smiles
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Therapeutic Uses
Anti-Cancer / Oncology
API Family
Clarithromycin
Storage Condition
Store at refrigerator (2-8°C) for long term storage
IUPAC Name
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-
methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12-hydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-
methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-7,13-dimethoxy-3,5,7,9,11,13-
hexamethyloxacyclotetradecane-2,10-dione
Synonyms
6,12-Di-O-methylerythromycin A; Clarithromycin Impurity F; 12-O-Methyl Clarithromycin
Application Notes
12-O-Methyl Clarithromycin is a methylated impurity of the semi-synthetic macrolide antibiotic Clarithromycin (C559750). 12-O-Methyl Clarithromycin was shown to inhibit uptake of Clarithromycin into the lung cells.
Chen, X, et al,: Zhong, Yao,, 17, 32 (2008); Yoshida, H, et al,: Jap, J, Antibiot,, 53, 615 (2000); Omura, S, et al,: Yakug, Zas,, 112, 593 (1992); "
Purity by HPLC
Not less than 90%
Hazard Compound
Refer MSDS for accurate information
12-O-Methyl Clarithromycin is a methylated impurity of the semi-synthetic macrolide antibiotic Clarithromycin (C559750). 12-O-Methyl Clarithromycin was shown to inhibit uptake of Clarithromycin into the lung cells.
Chen, X, et al,: Zhong, Yao,, 17, 32 (2008); Yoshida, H, et al,: Jap, J, Antibiot,, 53, 615 (2000); Omura, S, et al,: Yakug, Zas,, 112, 593 (1992); "
Refund Policy
We are committed to offering products of the highest quality in order to meet the needs of our customers, and have elaborate systems in
place to ensure that material specifications, their certification and all handling and storage conditions are communicated at the time of
material handover.
We have invested in the highest quality packaging materials and use international logistics partners to service our customers. While all
possible precautions have been taken to deliver the required product(s), there may be some rare situations when our product does not
meet your requirements. Should that arise, please contact us with your concerns and we will endeavour to address them on a priority
basis. If there is no other option, we will either replace your product(s) or issue a refund or account credit, whichever you prefer.
If there is an issue with one or more of our products, our policy is that it must be reported to us within 45 days of your receiving shipment.
While we will always address product issues after the 45 day return window has passed, we cannot issue a refund or account credit. As
always, we appreciate your support.
Clarithromycin EP Impurity F usage and description
Clarithromycin EP impurity F, also known as 1'-N-Desmethyl Clarithromycin, is a chemical compound that is commonly used in the pharmaceutical industry as a reference standard for quality control purposes. It is a structural impurity of Clarithromycin, a macrolide antibiotic that is used to treat a wide range of bacterial infections. The presence of Clarithromycin EP impurity F in Clarithromycin samples can affect the purity and potency of the drug, and can also lead to adverse effects in patients.
The chemical formula of Clarithromycin EP impurity F is C38H68N2O13, and its molecular weight is 760.95 g/mol. It is a white to off-white crystalline powder, and its melting point ranges from 168°C to 170°C. Clarithromycin EP impurity F is soluble in methanol, ethanol, and acetone, but is insoluble in water.
In terms of its usage, Clarithromycin EP impurity F is primarily used as a reference standard in the quality control of Clarithromycin drugs. It is also used in the development and validation of analytical methods for the detection and quantification of Clarithromycin impurities. The presence of Clarithromycin EP impurity F in Clarithromycin samples can affect the purity and potency of the drug, and can also lead to adverse effects in patients. Therefore, it is important to accurately detect and quantify this impurity to ensure the safety and efficacy of Clarithromycin drugs.
