Therapeutic Uses
Anti-Hypertensives
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Losartan Carboxylic acid-d4, 1246820-62-1
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
No -Refer MSDS for accurate information
Losartan Carboxylic acid-d4 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Losartan Carboxylic acid-d4 usage and description
Losartan carboxylic acid D4 is a deuterium-labeled analogue of Losartan carboxylic acid, which is a metabolite of Losartan, a medication used to treat hypertension (high blood pressure). Losartan is an angiotensin receptor blocker (ARB) that selectively blocks the binding of angiotensin II to the AT1 receptor, which leads to vasodilation and a decrease in blood pressure.
Losartan carboxylic acid D4 is primarily used as an internal standard for the quantification of Losartan carboxylic acid in biological samples using mass spectrometry. Mass spectrometry is a technique used to measure the mass-to-charge ratio of ions, which can be used to identify and quantify molecules based on their unique mass spectra. The deuterium-labeled analogue is used as an internal standard to accurately quantify the concentration of Losartan carboxylic acid in samples, as it allows for the correction of any potential errors in the sample preparation or analysis.
Chemically, Losartan carboxylic acid D4 is a deuterium-labeled analogue of Losartan carboxylic acid, with four deuterium atoms replacing four hydrogen atoms in the molecule. Its molecular formula is C12H5D4ClN2O3, and its molecular weight is 284.71 g/mol. Losartan carboxylic acid D4 is a white to off-white powder that is soluble in organic solvents such as methanol and acetonitrile.
In summary, Losartan carboxylic acid D4 is a deuterium-labeled analogue of Losartan carboxylic acid that is primarily used as an internal standard for the quantification of Losartan carboxylic acid in biological samples using mass spectrometry.
