Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
(±)-Nisoldipine D4 (2-nitrophenyl D4); 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl-d4)-3,5-pyridinedicarboxylic Acid Methyl 2-Methylpropyl Ester
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90 %
Hazard Compound
No -Refer MSDS for accurate information
Nisoldipine-d4 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Nisoldipine-d4 usage and description
Nisoldipine D4 is a deuterated version of the calcium channel blocker, Nisoldipine. It is commonly used in research studies to determine the pharmacokinetics and metabolism of Nisoldipine in vivo and in vitro. Deuterium labeling is a common technique used in drug development to improve the pharmacokinetics and drug metabolism of a compound.
Nisoldipine D4 is a dihydropyridine calcium channel blocker that works by inhibiting the influx of calcium ions into the smooth muscle cells of blood vessels, resulting in vasodilation and reduced blood pressure. It is primarily used in the treatment of hypertension, angina pectoris, and Raynaud's phenomenon.
The chemical structure of Nisoldipine D4 is C20H20D4N2O6, and it has a molecular weight of 412.48 g/mol. The compound is soluble in ethanol, methanol, and dimethyl sulfoxide (DMSO) but is insoluble in water. Nisoldipine D4 is a white to off-white crystalline powder that is stable under normal storage conditions.
The pharmacokinetics of Nisoldipine D4 have been extensively studied, and it has been found to have similar pharmacokinetic properties to Nisoldipine. However, the deuterium labeling of Nisoldipine D4 has been shown to improve the bioavailability, half-life, and clearance of the drug. This makes it a promising candidate for the development of improved versions of Nisoldipine for the treatment of hypertension and other cardiovascular diseases.
