Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Apremilast impurity D, 253168-87-5
Application Notes
Useful research chemical for a range of applications
Hazard Compound
No -Refer MSDS for accurate information
Apremilast impurity D is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
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Apremilast impurity D usage and description
Apremilast impurity D, also known as N-(2,6-difluorophenyl)-2-[(1-methyl-1H-pyrazol-5-yl)amino]acetamide, is a chemical compound that is used in the pharmaceutical industry as an impurity in the production of Apremilast, which is a drug used to treat psoriasis and psoriatic arthritis.
The usage of Apremilast impurity D is primarily as a reference standard to ensure the purity of the final product, Apremilast. It is important to ensure the purity of the final product as impurities can affect the efficacy and safety of the drug.
In terms of chemical information, Apremilast impurity D has the molecular formula C15H13F2N4O and a molecular weight of 314.29 g/mol. It is a white to off-white crystalline powder that is soluble in organic solvents such as methanol, ethanol and DMSO.
The synthesis of Apremilast impurity D involves the reaction between 2-amino-5-methyl-1H-pyrazole and 2,6-difluoroaniline in the presence of a coupling agent such as N,N'-diisopropylcarbodiimide (DIC) and catalytic amount of 4-dimethylaminopyridine (DMAP). The resulting product is then purified by recrystallization or chromatography.
Overall, Apremilast impurity D plays a crucial role in ensuring the quality and purity of Apremilast, which is an important drug in the treatment of psoriasis and psoriatic arthritis.
