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Dolutegravir O-beta-D-Glucuronide

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Product Code: CS-T-94635 Glucuronide Research Use Only
Dolutegravir O-beta-D-Glucuronide
Category
Glucuronide
API Family
Dolutegravir
Product Code
CS-T-94635
Research Status
For Laboratory Use

Dolutegravir O-beta-D-Glucuronide

Dolutegravir Glucuronide
Stock Status: In Stock
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CAT No.
CS-T-94635
CAS No.
1485692-21-4
Molecular Formula
C₂₆H₂₇F₂N₃O₁₁
Molecular Weight
595.51
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There is no hazardous surcharge associated with this product.
There is no packaging charge associated with this product.
For Research Purposes only. Not for Personal or Veterinary use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
1485692-21-4
Product Code
CS-T-94635
M.F.
C₂₆H₂₇F₂N₃O₁₁
M.W.
595.51
Smiles
O=C1C(N(C[C@@](OCC2)([H])N1[C@@H]2C)C=C3C(NCC(C=CC(F)=C4)=C4F)=O)=C(C3=O)O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]([C@H]5O)C(O)=O
Category
Glucuronide
API Family
Dolutegravir
Storage Condition
Store at refrigerator (2-8°C) for long term storage
IUPAC Name
(2S,3S,4S,5R,6S)-6-(((4R,12aS)-9-((2,4-Difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
References
Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011)
Synonyms
(2S,3S,4S,5R,6S)-6-(((4R,12aS)-9-((2,4-Difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
Application Notes
Dolutegravir O-β-D-Glucuronide is a metabolite of Dolutegravir (D528800); a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
Purity by HPLC
95.38%
Hazard Compound
Refer MSDS for accurate information.
Overview
Dolutegravir O-β-D-Glucuronide is a metabolite of Dolutegravir (D528800); a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

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