Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Afatinib, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Afatinib impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Afatinib-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.
Our Afatinib-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.
Afatinib Related Compounds
Stable Isotopes
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (2Z)-Afatinib-d6 | Stable Isotopes | CS-T-97835 | Not Available | Enquire |
| Afatinib-d6 | Stable Isotopes | CS-CX-00057 | 1313874-96-2 | In Stock |
| Afatinib-d6 Dimaleate | Stable Isotopes | CS-T-95339 | 1394292-94-4(Free base) | Enquire |
| Afatinib 13C6 | Stable Isotopes | CS-EK-02211 | 850140-72-6 unlabeled | Enquire |
| Afatinib D4 | Stable Isotopes | CS-O-13074 | 850140-72-6 ( Unlabeled) | Enquire |
API
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Afatinib | API | CS-T-01429 | 850140-72-6 | In Stock |
| Afatinib dimaleate | API | CS-O-12080 | 850140-73-7 | In Stock |
Metabolite
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| 4-Hydroxy 4-Dedimethylamino Afatinib | Metabolite | CS-O-32669 | 2121530-37-6 | Enquire |
| Afatinib-N-Oxide | Metabolite | CS-O-10178 | Not Available | Enquire |
Impurity
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (E)-4-(methylamino)but-2-enoic acid | Impurity | CS-O-60124 | 69169-63-7 | Enquire |
| Afatinib 5-hydroxypyrrolidin-2-one Impurity | Impurity | CS-EO-01168 | 2223677-58-3 | In Stock |
| Afatinib Bis-dimethylamino Impurity | Impurity | CS-O-56615 | 2414260-31-2 | Enquire |
| Afatinib dichloro impurity | Impurity | CS-ED-40634 | 2223677-63-0 | Enquire |
| Afatinib Dimer impurity | Impurity | CS-O-47043 | 2223677-65-2 | Enquire |
| Afatinib dimethyloxalamide impurity | Impurity | CS-O-47045 | 2223677-66-3 | Enquire |
| Afatinib Hydroxy impurity | Impurity | CS-O-47042 | 2223677-61-8 | Enquire |
| Afatinib Impurity 11 | Impurity | CS-O-57930 | 2413212-17-4 | Enquire |
| Afatinib Impurity 14 | Impurity | CS-O-57931 | 2413212-21-0 | Enquire |
| Afatinib Impurity 16 | Impurity | CS-EO-01556 | 2223677-60-7 | Enquire |
| Afatinib Impurity 2 | Impurity | CS-O-13086 | 1449430-45-8 | Enquire |
| Afatinib Impurity 27 | Impurity | CS-O-39522 | 618061-76-0 | Enquire |
| Afatinib Impurity 5 | Impurity | CS-O-13089 | 179552-74-0 | In Stock |
| Afatinib Impurity C | Impurity | CS-O-13077 | 945553-91-3 | Enquire |
| Afatinib Impurity H | Impurity | CS-O-13082 | 2223677-64-1 | Enquire |
| Afatinib imp-VI | Impurity | CS-O-34830 | Not Available | In Stock |
| Afatinib N-Oxide | Impurity | CS-EO-02865 | 2413212-11-8 | In Stock |
| Afatinib pyrrolidine-2,5-dione impurity | Impurity | CS-O-57964 | ---- | Enquire |
| (2Z)-Afatinib | Impurity | CS-T-65303 | 1680184-59-1 | Enquire |
| (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3... | Impurity | CS-T-72835 | 314771-88-5 | Enquire |
| Afatinib Butoxy Analog | Impurity | CS-EO-01232 | Not Available | Enquire |
| Afatinib Impurity 1 | Impurity | CS-O-13085 | Not Available | Enquire |
| Afatinib Impurity 10 | Impurity | CS-O-13094 | Not Available | Enquire |
| Afatinib Impurity 20 | Impurity | CS-EO-01428 | 1957132-02-3 | Enquire |
| Afatinib Impurity 22 | Impurity | CS-EO-01463 | Not Available | Enquire |
| Afatinib Impurity 23 | Impurity | CS-O-39578 | 2475095-50-0 | Enquire |
| Afatinib Impurity 3 | Impurity | CS-O-13087 | 2475094-96-1 | Enquire |
| Afatinib Impurity 4 | Impurity | CS-O-37644 | 2512206-82-3 | Enquire |
| Afatinib Impurity 4 | Impurity | CS-O-13088 | 2512206-82-3 | Enquire |
| Afatinib Impurity 6 | Impurity | CS-O-13090 | Not Available | Enquire |
| Afatinib Impurity 7 | Impurity | CS-O-13091 | Not Available | Enquire |
| Afatinib Impurity 8 | Impurity | CS-O-13092 | Not Available | Enquire |
| Afatinib Impurity 9 | Impurity | CS-O-13093 | 2413212-10-7 | Enquire |
| Afatinib Impurity A | Impurity | CS-O-13075 | 402855-07-6 | Enquire |
| Afatinib Impurity E | Impurity | CS-O-13079 | 2223677-63-0 | Enquire |
| Afatinib Impurity F | Impurity | CS-O-13080 | 2223677-62-9 | Enquire |
| Afatinib Impurity G | Impurity | CS-O-13081 | Not Available | Enquire |
| Afatinib Impurity I | Impurity | CS-O-13083 | Not Available | Enquire |
| Afatinib Impurity J HCl | Impurity | CS-O-13084 | 1456696-14-2 (keto form) | Enquire |
| Afatinib Impurity K | Impurity | CS-P-08916 | Not Available | Enquire |
| Afatinib Maleic Acid Adduct | Impurity | CS-P-08729 | Not Available | Enquire |
| Afatinib Sulfonic Acid Analog | Impurity | CS-EO-01233 | 2283295-16-7 | Enquire |
| ethyl (E)-4-(dimethylamino)but-2-enoate hydrochloride | Impurity | CS-EO-01465 | 1255078-56-8 | Enquire |
Intermediate
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)ox... | Intermediate | CS-O-13076 | 314771-76-1 | In Stock |
| trans-4-Dimethylaminocrotonic acid hydrochloride | Intermediate | CS-M-57341 | 848133-35-7 | In Stock |
Fine Chemicals
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| N-(3,4-Difluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine | Fine Chemicals | CS-O-37645 | 2226537-61-5 | Enquire |
Nitrosamine
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Afatinib Nitroso Impurity 2 | Nitrosamine | CS-O-53320 | Not Available | In Stock |
| N-Nitroso Afatinib | Nitrosamine | CS-O-38947 | ---- | Discontinued |
Therapeutic
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Afatinib Impurity D | Therapeutic | CS-O-13078 | 1680184-59-1 | Enquire |