Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Tofacitinib, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Tofacitinib impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Tofacitinib-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.
Our Tofacitinib-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.
Tofacitinib Related Compounds
Stable Isotopes
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (3R,4S)-Tofacitinib-D3 | Stable Isotopes | CS-T-96145 | 1092578-46-5 (Unlabelled) | Enquire |
| N-Nitroso Tofacitinib Amine Impurity D3 | Stable Isotopes | CS-O-53626 | ---- | Enquire |
| Tofacitinib 13C d3 | Stable Isotopes | CS-EO-02588 | Not Available | Enquire |
| Tofacitinib-13C | Stable Isotopes | CS-O-48660 | 477600-75-2(Unlabelled) | Enquire |
| Tofacitinib-13C3 | Stable Isotopes | CS-O-10298 | 477600-75-2(unlabeled) | Enquire |
| Tofacitinib-13C3,15N | Stable Isotopes | CS-AI-00211 | 477600-75-2 (Unlabeled) | Enquire |
| Tofacitinib-13C3,15N Citrate | Stable Isotopes | CS-O-47447 | 2256762-71-5 (Freebase) | In Stock |
| (3S,4R)-Tofacitinib-d3 | Stable Isotopes | CS-T-97135 | Not Available | Enquire |
| (3S,4S)-Tofacitinib-d3 | Stable Isotopes | CS-T-97136 | Not Available | Enquire |
| Tofacitinib 13C D2 15N | Stable Isotopes | CS-O-32721 | 477600-75-2 (Unlabeled) | Enquire |
| Tofacitinib Citrate-d3 | Stable Isotopes | CS-EO-00265 | 540737-29-9 (Unlabelled) | Enquire |
| Tofacitinib D3 | Stable Isotopes | CS-O-36333 | 477600-75-2 (Unlabeled) | Enquire |
API
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Tofacitinib | API | CS-O-10853 | 477600-75-2 | In Stock |
Metabolite
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Racemic Tofacitinib metabolite - 1 | Metabolite | CS-O-52475 | 1269823-96-2 | Enquire |
| Tofacitinib metabolite-1 | Metabolite | CS-O-43355 | 1640971-51-2 | Enquire |
Impurity
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (3R,4S)-Tofacitinib citirate | Impurity | CS-O-39729 | 2174011-53-9 | Enquire |
| (3R,4S)-Tofacitinib | Impurity | CS-T-62103 | 1092578-46-5 | In Stock |
| (3S,4R)-Tofacitinib | Impurity | CS-T-62105 | 1092578-48-7 | In Stock |
| (3S,4S)-Tofacitinib | Impurity | CS-T-62104 | 1092578-47-6 | Enquire |
| 2,4-Dichloro-7H-Pyrrolo (2,3-d)Pyrimidine | Impurity | CS-M-42734 | 90213-66-4 | In Stock |
| 3H-pyrrolo[2,3-d]pyrimidin-4(5H)-one | Impurity | CS-O-55715 | 1194710-85-4 | Enquire |
| N-(1-benzyl-4-methylpiperidin-3-yl)-N-methylnitrous amide | Impurity | CS-O-45589 | Not Available | Enquire |
| N-Desmethyl Tofacitinib | Impurity | CS-O-54946 | 1527525-58-1 | Enquire |
| N-methyl-N-(4-methylpiperidin-3-yl)nitrous amide | Impurity | CS-O-45599 | Not Available | Enquire |
| N-methyl-N-(4-methylpyridin-3-yl)nitrous amide | Impurity | CS-O-46286 | Not Available | Enquire |
| Tofacitinib formyl impurity | Impurity | CS-EO-01760 | 2227199-28-0 | In Stock |
| Tofacitinib Benzyl Impurity | Impurity | CS-T-88424 | 477600-73-0 | In Stock |
| Tofacitinib butyl ester impurity | Impurity | CS-O-43010 | Not Available | Enquire |
| Tofacitinib Butyl Impurity | Impurity | CS-O-54081 | 2716897-36-6 | Enquire |
| Tofacitinib Citrate Diasteromeric impurity | Impurity | CS-O-46779 | 2664002-63-3 | Enquire |
| Tofacitinib Diastereomer | Impurity | CS-EO-00128 | 344418-92-4 (Freebase) | Enquire |
| Tofacitinib Diastereomer-1 and 2 | Impurity | CS-O-33660 | 2734856-31-4 | Enquire |
| Tofacitinib Dihydro Citricacid salt impurity | Impurity | CS-O-44098 | 1809002-40-1 | Enquire |
| Tofacitinib Dihydro Impurity | Impurity | CS-T-89311 | 1640972-35-5 | In Stock |
| Tofacitinib Dimer | Impurity | CS-O-57969 | ---- | Enquire |
| Tofacitinib Hydroxy Impurity | Impurity | CS-EO-02225 | 1092578-46-5 | Enquire |
| Tofacitinib Impurity 19 | Impurity | CS-O-58215 | 2459302-82-8 | Enquire |
| Tofacitinib Impurity 29 | Impurity | CS-EO-03056 | 2459302-85-1 | Enquire |
| Tofacitinib Impurity 57 | Impurity | CS-EO-03055 | 2315287-12-6 | Enquire |
| Tofacitinib Impurity 59 | Impurity | CS-O-58346 | 32018-56-7 | Enquire |
| Tofacitinib Impurity 6 | Impurity | CS-EO-01450 | 2504210-38-0 | In Stock |
| Tofacitinib Impurity 67 | Impurity | CS-O-57488 | 2716897-35-5 | Enquire |
| Tofacitinib Impurity G | Impurity | CS-AQ-00037 | 1354486-07-9 | In Stock |
| Tofacitinib impurity K | Impurity | CS-AQ-00040 | 2328165-36-0 | In Stock |
| Tofacitinib Impurity L | Impurity | CS-AQ-00041 | 1675248-19-7 | In Stock |
| TOFACITINIB IMPURITY TOF-IV | Impurity | CS-O-49452 | 2227197-38-6 | Enquire |
| Tofacitinib impurity X | Impurity | CS-AQ-00050 | 2097982-05-1 | Enquire |
| Tofacitinib N-Descyanoacetyl Hydrochloride Impurity | Impurity | CS-O-10647 | 1260590-51-9 | In Stock |
| Tofacitinib N-Oxide Impurity | Impurity | CS-T-89823 | 2028267-73-2 | Enquire |
| (3S,4R) Tofacitinib Citrate | Impurity | CS-O-39728 | 2174011-54-0 | Enquire |
| 1-Piperidinepentanoic acid, γ-cyano-β-imino-4-methyl-3-(meth... | Impurity | CS-O-40534 | 2102039-99-4 | Enquire |
| 3-((3R,4R)-4-methyl-3-(methyl((5R,6S)-2,5,6-trihydroxy-6,7-d... | Impurity | CS-O-35885 | 2102039-98-3 | Enquire |
| 3-[(3R,4R)-4-methyl-3-[methyl({7H-pyrrolo[2,3-d]pyrimidin-4-... | Impurity | CS-O-36711 | Not Available | Enquire |
| 5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one | Impurity | CS-EM-02923 | 5817-96-9 | Enquire |
| Tofacitinib Impurity (N-Des-(2-Cyanide-acetyl)-(3S,4R)) | Impurity | CS-EO-01834 | 2378663-15-9 | Enquire |
| Tofacitinib Impurity 16 | Impurity | CS-O-40535 | 2102040-00-4 | Enquire |
| Tofacitinib Impurity 36 | Impurity | CS-EO-01537 | Not Available | Enquire |
| Tofacitinib impurity C | Impurity | CS-AQ-00034 | Not Available | Enquire |
| Tofacitinib impurity F | Impurity | CS-AQ-00036 | Not Available | Enquire |
| Tofacitinib impurity I | Impurity | CS-AQ-00038 | Not Available | Enquire |
| Tofacitinib impurity J | Impurity | CS-AQ-00039 | 1431697-80-1 | Enquire |
| Tofacitinib impurity N | Impurity | CS-AQ-00042 | 1260614-73-0 | Enquire |
| Tofacitinib impurity P | Impurity | CS-AQ-00044 | 1252883-90-1 | Enquire |
| Tofacitinib impurity T | Impurity | CS-AQ-00046 | Not Available | Enquire |
| Tofacitinib impurity U | Impurity | CS-AQ-00047 | Not Available | Enquire |
| Tofacitinib impurity V | Impurity | CS-AQ-00048 | 1616761-00-2 | Enquire |
| Tofacitinib impurity W | Impurity | CS-AQ-00049 | Not Available | Enquire |
| Tofacitinib impurity Z | Impurity | CS-AQ-00052 | 477600-76-3 | Enquire |
| Tofacitinib- Keto Impurity | Impurity | CS-DN-00028 | Not Available | Enquire |
| Tofacitinib N- acid Impurity | Impurity | CS-DN-00027 | Not Available | Enquire |
| Tofacitinib N-hydroxy impurity | Impurity | CS-EO-00807 | Not Available | Enquire |
| Tofacitinib Related Compound 26 HCl | Impurity | CS-P-02224 | 1206824-85-2 | Enquire |
| Tofacitinib related compound 6 | Impurity | CS-P-02196 | 2459302-77-1 | Enquire |
Intermediate
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Tofacitinib Amine intermediate | Intermediate | CS-O-32365 | 477600-74-1 | In Stock |
Fine Chemicals
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (3R,4R)-3-[(6-Amino-4-pyrimidinyl)methylamino]-4-methyl-β-ox... | Fine Chemicals | CS-TA-06370 | 1640971-60-3 | In Stock |
| (3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine | Fine Chemicals | CS-ZG-47294 | 1354621-59-2 | Enquire |
| 2-Descyano-2-ethyl Formyl-tofacitinib | Fine Chemicals | CS-ZH-31805 | 1675248-18-6 | In Stock |
| Ethyl Cyanoacetate | Fine Chemicals | CS-T-22644 | 105-56-6 | In Stock |
| N-((3R,4R)-1-BENZYL-4-METHYLPIPERIDIN-3-YL)-N-METHYL-7-TOSYL... | Fine Chemicals | CS-ZH-34968 | 923036-30-0 | Enquire |
| rel-N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2... | Fine Chemicals | CS-ZH-18555 | 1206825-36-6 | Enquire |
| Tofacitinib Related Substance 1 | Fine Chemicals | CS-RS-00136 | 2101958-24-9 | Enquire |
| Tofacitinib Related Substance 2 | Fine Chemicals | CS-RS-00137 | 2101951-13-5 | Enquire |
Nitrosamine
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| 1,2,3,6,-tetrahydro-1- nitroso4-picoline | Nitrosamine | CS-O-45591 | 89600-66-8 | Enquire |
| Desmethyl Tofacitinib Nitroso impurity | Nitrosamine | CS-O-53570 | ---- | Enquire |
| N,4-dimethyl-1-nitrosopiperidin-3-amine | Nitrosamine | CS-O-45597 | Not Available | Enquire |
| N-methyl-N-((3R,4R)-4-methyl-1-nitrosopiperidin-3-yl)nitrous... | Nitrosamine | CS-O-54597 | ---- | Enquire |
| N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl) nitrous amide | Nitrosamine | CS-O-54598 | ---- | Enquire |
| N-methyl-N-(4-methyl-1-nitrosopiperidin-3-yl)nitrous amide | Nitrosamine | CS-O-45598 | Not Available | Enquire |
| N-Nitroso 5,6-Dihydro Tofacitinib | Nitrosamine | CS-O-55091 | ---- | Enquire |
| N-Nitroso Tofacitinib Amine Impurity | Nitrosamine | CS-O-40197 | Not Available | In Stock |
| N-Nitroso Tofacitinib Amine Impurity D4 | Nitrosamine | CS-O-53679 | ---- | Enquire |
| N-Nitroso Tofacitinib Impurity 2 | Nitrosamine | CS-EO-02869 | Not Available | Discontinued |
| N-Nitroso Tofacitinib Impurity 6 | Nitrosamine | CS-O-49684 | ---- | Enquire |
| Tofacitinib Nitroso Impurity | Nitrosamine | CS-EO-01989 | ---- | Discontinued |
| Tofacitinib Nitroso Impurity 1 | Nitrosamine | CS-O-45592 | Not Available | Enquire |
| Tofacitinib Nitroso Impurity 2 | Nitrosamine | CS-O-45593 | ---- | Enquire |
| Tofacitinib Nitroso Impurity 3 | Nitrosamine | CS-O-45594 | ---- | Enquire |
| Tofacitinib Nitroso Impurity 4 | Nitrosamine | CS-O-45595 | Not Available | Enquire |
| Tofacitinib Nitroso Impurity 5 | Nitrosamine | CS-O-45596 | Not Available | Enquire |
| Tofacitinib N-Nitroso benzyl intermediate | Nitrosamine | CS-O-47117 | Not Available | In Stock |
| Tofacitinib N-Oxide Impurity 6 | Nitrosamine | CS-O-53686 | ---- | Discontinued |
Stable Isotope Reagent
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| N-Nitroso Tofacitinib Amine Impurity-d5 | Stable Isotope Reagent | CS-O-54128 | Not Available | In Stock |
Therapeutic
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Enantiomer of Tofacitinib citrate | Therapeutic | CS-O-33661 | 2174011-55-1 | Enquire |
| Tofacitinib Citrate | Therapeutic | CS-T-51291 | 540737-29-9 | Enquire |
Building Blocks
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| Tofacitinib intermeduate racemic | Building Blocks | CS-O-44035 | Not Available | Enquire |