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Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Sacubitril, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Sacubitril impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Sacubitril-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.

Sacubitril Related Compounds

Stable Isotopes

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(2S,4R)-Sacubitril D4 Stable Isotopes CS-EO-02577 761373-05-1Unlabelled Enquire
Desethyl Sacubitril-13C4 Stable Isotopes CS-T-100536 Not Available Enquire
Sacubitrilat-13C4 Stable Isotopes CS-O-40812 Not Available Enquire
Sacubitrilat-d4 Stable Isotopes CS-O-16369 149709-44-4(Unlabeled) In Stock
Sacubitrilat-d5 Stable Isotopes CS-B-00379 2249814-81-9 Enquire
Sacubitril-d4 Stable Isotopes CS-O-15672 1884269-07-1 In Stock
Sacubitril-d4 Calcium Stable Isotopes CS-O-16522 1369773-39-6 (Unlabeled) In Stock
Sacubitril-d5 Calcium Salt Stable Isotopes CS-B-00380 1369773-39-6 Enquire
(2S, 4S)-Sacubitril-d4 Stable Isotopes CS-P-02624 149709-63-7(Unlabeled) Enquire
Desethyl Sacubitril-d4 Stable Isotopes CS-T-95087 Not Available Enquire
Sacubitril 13C4 Stable Isotopes CS-O-14963 149709-62-6(Unlabeled) Enquire
Sacubitril 13C4 Calcium Stable Isotopes CS-O-35165 1369773-39-6 (Unlabeled) Enquire
Sacubitril metabolite LBQ 657 13C4 Stable Isotopes CS-EK-00723 149709-44-4 unlabeled Enquire
Sacubitril metabolite LBQ657 13C4 Stable Isotopes CS-O-14964 149709-44-4 (Unlabeled) Enquire
Sacubitril sodium salt 13C4 Stable Isotopes CS-EK-00613 149690-05-1 unlabeled Enquire


API

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Sacubitril API CS-AV-00004 149709-62-6 In Stock
Sacubitril Calcium API CS-O-16411 1369773-39-6 In Stock
Sacubitril sodium API CS-EK-00357 149690-05-1 In Stock
Sacubitril Tert Butylamine API CS-EO-03844 1924620-56-3 Enquire
Sacubitril Tromethamine API CS-EO-02870 565453-99-8 Enquire
Sacubitril-valsartan Sodium Hydrate API CS-O-46700 1884447-69-1 In Stock
Valsartan Sacubitril Sodium Hemipentahydrate Salt API CS-O-13857 936623-90-4 In Stock


Metabolite

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Sacubitril metabolite LBQ 657 Metabolite CS-O-14962 149709-44-4 In Stock


Impurity

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
((2R,4S)-5-([1,1'-biphenyl]-4-yl)-2-methyl-4-nitropentanoic ... Impurity CS-O-58093 1982356-32-0 Enquire
(2R,4S)-Ethyl-5-([1,1`-biphenyl]-4-yl)-4-amino-2-methylpenta... Impurity CS-DV-00448 149690-12-0 In Stock
(R)-2-(tert-butylamino)-3-(4-iodophenyl)propan-1-ol Impurity CS-O-49667 Not Available Enquire
(Z)-Sacubitril Maleic Acid Impurity CS-T-95958 2751722-77-5 Enquire
2R,4S Sacubitril 2-methylpropan-2-aminium Impurity Impurity CS-O-52145 Not Available Enquire
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-isopropoxy-4-methyl-5... Impurity CS-O-40504 2514965-95-6 In Stock
Ene Sacubitril Impurity CS-O-39596 2957885-24-2 Enquire
Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpenta... Impurity CS-O-58094 ---- Enquire
Ethyl 2-(Triphenylphosphoranylidene)Propanoate Impurity CS-M-56777 5717-37-3 In Stock
Methyl (2Z)-2-(acetylamino)-3-(biphenyl-4-yl)-2-propenoate Impurity CS-O-47555 556828-95-6 Enquire
Sacubitril (4S) Boc Hydrochloride Impurity CS-O-50029 149709-61-5(Freebase) Enquire
Sacubitril cyclized boc impurity Impurity CS-O-45689 1835193-03-7 Enquire
Sacubitril Ene impurity Impurity CS-O-42257 2751722-75-3 Enquire
Sacubitril Ethyl ester Impurity CS-O-35155 2376611-98-0 Enquire
Sacubitril ethyl Impurity Impurity CS-MM-76977 149709-59-1 Enquire
Sacubitril Impurity 1 Impurity CS-P-02116 1038924-70-7 In Stock
Sacubitril Impurity 10 Impurity CS-O-15830 149709-60-4 In Stock
Sacubitril Impurity 11 Impurity CS-O-15831 1039307-95-3 Enquire
Sacubitril Impurity 13 Impurity CS-EO-04002 2459446-51-4 In Stock
Sacubitril Impurity 14 Impurity CS-EO-04000 2216755-67-6 In Stock
Sacubitril Impurity 17 Impurity CS-EO-00381 2216747-18-9 In Stock
Sacubitril Impurity 18 Impurity CS-O-14054 1426129-50-1 In Stock
Sacubitril Impurity 2 Impurity CS-P-02117 1038924-97-8 In Stock
Sacubitril Impurity 20 Impurity CS-EO-04003 2459446-55-8 In Stock
Sacubitril Impurity 21 Impurity CS-O-55165 1817838-91-7 Enquire
Sacubitril Impurity 3 Impurity CS-P-02118 1038925-00-6 Enquire
Sacubitril Impurity 43 HCl Impurity CS-O-45950 149690-13-1 Enquire
Sacubitril Impurity 44 HCl Impurity CS-O-45951 2101223-17-8 Enquire
Sacubitril Impurity 45 HCl Impurity CS-O-45949 2259707-96-3 Enquire
Sacubitril Impurity 48 Impurity CS-EO-03178 1426129-52-3 Enquire
Sacubitril Impurity 49 HCl salt Impurity CS-O-33144 1933501-50-8 In Stock
Sacubitril Impurity 57 Impurity CS-EO-04001 1639970-62-9 In Stock
Sacubitril Impurity 59 Impurity CS-O-60112 ---- Enquire
Sacubitril Impurity 6 Impurity CS-O-15827 1012341-54-6 In Stock
Sacubitril Impurity 69 Impurity CS-EO-03133 2131788-25-3 Enquire
Sacubitril Impurity 8 Impurity CS-O-13858 1012341-50-2 In Stock
Sacubitril Impurity 85 Impurity CS-O-60026 ---- Enquire
Sacubitril Isopropyl ester Impurity CS-O-46586 2459446-53-6 In Stock
Sacubitril lactam impurity Impurity CS-O-45057 2459446-54-7 Enquire
Sacubitril Maleic Acid (E-Isomer) Impurity CS-EO-00802 2984580-03-0 In Stock
Sacubitril Methyl ester Impurity CS-EO-00516 2408053-56-3 In Stock
Sacubitril Methyl ester Tert Butylamine Impurity CS-O-38389 2408053-56-3 (Freebase) Enquire
Sacubitril N-Acetyl Impurity Impurity CS-O-40162 Not Available In Stock
Sacubitril Propyl Ester Impurity CS-O-40925 2751722-76-4 In Stock
Sacubitril Pyrrolidinone Impurity Impurity CS-O-49085 1038925-22-2 In Stock
Sacubitril TBA Salt Impurity CS-EO-03843 1924620-55-2 Enquire
Sacubitril-(2R,4R)-Isomer Impurity CS-EO-02012 2259708-00-2 In Stock
Sacubitril-(2R,4S) Isomer Impurity CS-ZE-25991 761373-05-1 In Stock
Sacubitril(E)2-methylpropan-2-aminium Impurity Impurity CS-O-52144 Not Available Enquire
(2R,4S)-Sacubitril-O-isobutane Impurity CS-T-86048 149709-64-8 Enquire
(2S,4S)-Sacubitril-O-isobutane Impurity CS-T-85183 149709-65-9 Enquire
(3R,5S)-5-[1,1′-Biphenyl]-4-yl-3-methyl-2-pyrrolidinone Impurity CS-O-55117 2459446-50-3 Enquire
(R)-1-([1,1'-biphenyl]-4-yl)-3-(benzyloxy)propan-2-amine hyd... Impurity CS-O-35371 Not Available Enquire
(R)-2-(1-([1,1'-biphenyl]-4-yl)-3-(benzyloxy)propan-2-yl)iso... Impurity CS-O-35374 Not Available Enquire
(R)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-(benzyloxy)propan... Impurity CS-O-35372 Not Available Enquire
(R,E)-4-((1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxope... Impurity CS-O-39571 Not Available Enquire
(S)-1-([1,1'-biphenyl]-4-yl)-3-(benzyloxy)propan-2-ol Impurity CS-O-35370 Not Available Enquire
(αS)-α-(Chloromethyl)[1,1'-biphenyl]-4-ethanol Impurity CS-O-39495 1573000-28-8 Enquire
1,1-Dimethylethyl N-[(2S)-3-[1,1'-biphenyl]-4-yl-2-hydroxypr... Impurity CS-O-40118 1810778-75-6 Enquire
2-methylpropan-2-amine 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-... Impurity CS-O-41083 Not Available Enquire
2-Methylpropan-2-aminium(Z)-4-(((2S,4R)-1-([1,1-biphenyl]-4y... Impurity CS-O-36777 Not Available Enquire
4-((3R,5S)-5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrr... Impurity CS-TA-30797 2216746-87-9 Enquire
Carbamic acid, [(1R)​-​2-​(acetyloxy)​-​1-​([1,​1'-​biphenyl... Impurity CS-O-40116 219718-02-2 Enquire
N-[(1R)-2-[1,1'-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]acetam... Impurity CS-O-40117 1660147-07-8 Enquire
NAP006-06 (Z isomer) Impurity CS-O-40119 1361408-16-3 Enquire
Rel-(2R,4R)-Sacubitril Impurity CS-T-85986 766480-48-2 Enquire
Sacubitril acid IsoPropyl Ester Impurity CS-O-49909 2984580-04-1 Enquire
Sacubitril Enantiomer (2S,4R) calcium salt Impurity CS-O-15825 761373-05-1 (free base) Enquire
Sacubitril Impurity 24 Impurity CS-EO-01069 Not Available Enquire
Sacubitril Impurity 5 Impurity CS-O-15826 1012341-56-8 Enquire
Sacubitril Impurity 7 Impurity CS-O-15828 1012341-52-4 Enquire
Sacubitril Impurity 9 Impurity CS-O-15829 752174-62-2 Enquire
Sacubitril-(2R,4R)-Isomer calcium salt Impurity CS-O-15823 2259708-00-2 (free base) Enquire
Sacubitril-(2S,4S)-Isomer calcium salt Impurity CS-O-15824 149709-63-7 (free base) Enquire


Intermediate

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone Intermediate CS-M-57845 131685-53-5 In Stock
(R)-methyl 3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)... Intermediate CS-O-47269 149818-98-4 Enquire
(R)-methyl 3-([1,1'-biphenyl]-4-yl)-2-acetamidopropanoate Intermediate CS-O-47268 164460-67-7 Enquire
(R)-tert-butyl (3-([1,1'-biphenyl]-4-yl)-1-hydrazinyl-1-oxop... Intermediate CS-O-47270 919528-68-0 Enquire
1-Ethoxy-1-oxopropan-2-yl)triphenylphosphonium bromide Intermediate CS-O-47271 30018-16-7 Enquire
Isopropyl 4-((3R,5S)-5-([1,1'-biphenyl]-4-ylmethyl)-3-methyl... Intermediate CS-O-52271 2149600-13-3 In Stock
Sacubitril Bromo intermediate Intermediate CS-O-45494 1835193-08-2 Enquire


Glucuronide

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Sacubitril Acyl-glucuronide Glucuronide CS-T-96009 Not Available Enquire
Sacubitrilat Acyl-glucuronide Glucuronide CS-T-96010 Not Available Enquire


Fine Chemicals

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
[(1R)-2-(Biphenyl-4-yl)-1-formylethyl]carbamic acid tert-but... Fine Chemicals CS-O-33529 149709-58-0 Enquire


Nitrosamine

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
N-Nitroso Sacubitril Nitrosamine CS-O-44587 Not Available Discontinued
N-Nitroso Sacubitril acid impurity Nitrosamine CS-O-53134 ---- Enquire
N-Nitroso Sacubitril Impurity 1 Nitrosamine CS-P-09070 Not Available Enquire
N-Nitroso Sacubitril impurity 6 Nitrosamine CS-O-53135 ---- Enquire
N-Nitroso Sacubitril Valsartan Nitrosamine CS-O-44588 Not Available Enquire
N-Nitroso Sacubitril Nitrosamine CS-O-52994 ---- Enquire
N-Nitroso Sacubitril acid impurity Nitrosamine CS-O-52993 ---- Enquire


Pharmaceutical Stds.

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(4-ethoxy-4-oxobutanamido... Pharmaceutical Stds. CS-TA-30796 149709-49-9 In Stock


Chiral

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent... Chiral CS-O-14053 1012341-48-8 In Stock