Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Proline, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Proline impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Proline-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.
Our Proline-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.
Proline Related Compounds
Stable Isotopes
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (4S)-4-(Phenylthio)-L-proline-d5 Hydrochloride | Stable Isotopes | CS-T-94385 | 105107-84-4(Unlabelled) | Enquire |
| Cis-4-Hydroxy-L-proline-2,5,5 D3 | Stable Isotopes | CS-O-15051 | 618-27-9 (Unlabeled) | Enquire |
| Des(4-cyclohexyl-L-proline) Fosinopril Acetic Acid-d7 | Stable Isotopes | CS-T-97635 | Not Available | Enquire |
| DL-Proline-2,5,5-d3 | Stable Isotopes | CS-T-94101 | 784086-28-8 | Enquire |
| L-Alanyl-L-proline-d3 t-Butyl Ester | Stable Isotopes | CS-T-100917 | Not Available | Enquire |
| L-Proline-d3-N-Fmoc | Stable Isotopes | CS-T-99862 | Not Available | Enquire |
| N-Nitroso L-Proline-d3 | Stable Isotopes | CS-O-11223 | 2140267-23-6 | In Stock |
| N-Nitroso-DL-Proline-d3 | Stable Isotopes | CS-O-10299 | 65807-08-1 | In Stock |
| N-Nitroso-L-proline D7 | Stable Isotopes | CS-O-53737 | 7519-36-0 (Unlabeled) | Enquire |
| rac-Des(4-cyclohexyl-L-proline) Fosinopril Acetic Acid-d7 | Stable Isotopes | CS-T-101091 | Not Available | Enquire |
| S-(Pentafluoro-6-methylbenzene) Captopril (Proline-2,5,5-d3) | Stable Isotopes | CS-T-97228 | Not Available | Enquire |
| S-[3-(2,5,6-Trimethyl)bimanyl] Captopril (Proline 2,5,5-d3) | Stable Isotopes | CS-T-97126 | Not Available | Enquire |
| trans-4-Hydroxy-L-proline-d4 (Major) | Stable Isotopes | CS-T-102915 | 2734920-51-3 | Enquire |
| trans-4-Hydroxy-L-proline-d6 | Stable Isotopes | CS-T-100179 | Not Available | Enquire |
| (4R)-1-Methyl-4-propyl-L-proline-d3 Methyl Ester | Stable Isotopes | CS-T-81532 | 1246815-09-7 | Enquire |
| (trans)-4-Propyl-1-methyl-L-proline-d3 | Stable Isotopes | CS-T-85221 | 1246816-92-1 | Enquire |
| [1,2-13C2,15N]-L-Proline | Stable Isotopes | CS-EK-01682 | 219491-68-6 | Enquire |
| [2-13C]-L-Proline | Stable Isotopes | CS-EK-01753 | 219491-78-8 | Enquire |
| [2-13C]-L-Proline amide | Stable Isotopes | CS-EK-00707 | 7531-52-4 unlabeled | Enquire |
| 1-Nitroso-DL-proline 13C5,15N | Stable Isotopes | CS-EK-01248 | 2571-28-0 unlabeled | Enquire |
| 5-Oxo-DL-proline D5 | Stable Isotopes | CS-T-60039 | 352431-30-2 | Enquire |
| D-Proline-13C5,15N | Stable Isotopes | CS-T-85875 | 1331908-17-8 | Enquire |
API
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| L-Proline rubidium salt | API | CS-O-51900 | 151600-44-1 | Enquire |
| (+/-)-Homoproline | API | CS-T-26370 | 56879-46-0 | Enquire |
| Fructose-proline | API | CS-T-55098 | 29118-61-4 | Enquire |
| N-Glycylproline | API | CS-T-25649 | 704-15-4 | Enquire |
Metabolite
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| N-Boc-4-oxo-L-proline methyl ester | Metabolite | CS-M-42334 | 102195-80-2 | Enquire |
Impurity
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| ((S)-4-(2-chlorophenyl)-1-ethoxy-1-oxobutan-2-yl)-L-alanyl-L... | Impurity | CS-O-58632 | 85918-76-9 | Enquire |
| ((S)-4-(4-chlorophenyl)-1-ethoxy-1-oxobutan-2-yl)-L-alanyl-L... | Impurity | CS-O-58633 | ---- | Enquire |
| (4R)-4-[2-(1,1-Dimethylethoxy)-2-oxoethoxy]-L-proline | Impurity | CS-O-58110 | 2173568-86-8 | Enquire |
| (4S)-4-(Phenylthio)-L-proline Hydrochloride | Impurity | CS-T-60509 | 105107-84-4 | In Stock |
| (R)-hydroxyproline amino benzoic acid | Impurity | CS-O-48684 | 444057-65-2 | Enquire |
| (Trans)-4-Cyclohexylproline | Impurity | CS-O-32305 | 103201-78-1 | Enquire |
| 1-(N-(S-1-Carboxy-3-cyclohexylpropyl)-L-Alanyl) L-Proline-et... | Impurity | CS-O-56402 | ---- | Enquire |
| 1-(tert-butyl) 2-methyl (2S,4R)-4-fluoropyrrolidine-1,2-dica... | Impurity | CS-BX-02491 | 203866-18-6 | In Stock |
| Dapagliflozin Diproline | Impurity | CS-EO-03461 | 960404-62-0 | Enquire |
| DL-Proline | Impurity | CS-T-40571 | 609-36-9 | In Stock |
| Eletriptan Ethyl Indole Proline | Impurity | CS-T-54521 | 209682-64-4 | In Stock |
| Fmoc-O-tert-butyl-D-trans-4-hydroxyproline | Impurity | CS-BX-02694 | 268729-12-0 | Enquire |
| Ipragliflozin L-Proline | Impurity | CS-O-13214 | 951382-34-6 | In Stock |
| Lisinopril Des-Proline Dimer – I | Impurity | CS-P-08294 | Not Available | In Stock |
| Lisinopril Des-Proline Dimer-II | Impurity | CS-P-08292 | ---- | In Stock |
| L-Proline β-naphthylamide hydrochloride | Impurity | CS-BX-02706 | 97216-16-5 | Enquire |
| Pidotimod (R,R)-Thioproline dimer impurity | Impurity | CS-O-46196 | Not Available | Enquire |
| (+)-cis-(2R,3S)-3-hydroxyproline | Impurity | CS-DV-00013 | 118492-86-7 | Enquire |
| (4R)-1-Boc-4-methyl-D-proline | Impurity | CS-AC-04141 | 871727-77-4 | Enquire |
| (4R)-4-Benzyloxy-L-Proline methyl ester | Impurity | CS-AC-03840 | 113490-76-9 | Enquire |
| (4S)-4-Cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acety... | Impurity | CS-T-14174 | 474382-58-6 | Enquire |
| (R)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-pro... | Impurity | CS-T-76443 | 139492-22-1 | Enquire |
| (R)-1-Cbz-beta-proline ethyl ester | Impurity | CS-AC-04180 | 1263078-10-9 | Enquire |
| (R)-2-Methyl Proline | Impurity | CS-T-79813 | 63399-77-9 | Enquire |
| (S)-Homoproline hydrochloride | Impurity | CS-MM-46335 | 53912-85-9 | Enquire |
| 1-(1-Oxopropyl)-(4S)-4-cyclohexyl-L-proline | Impurity | CS-T-59842 | 1421283-57-9 | Enquire |
| 1-(3,3-Dimethyl-1,2-dioxopentyl)-L-proline 3-(3-pyridinyl)pr... | Impurity | CS-T-53532 | 186452-09-5 | Enquire |
| 1-[(2R)-3-(acetylthio)-2-methyl-1-oxopropyl]-D-Proline | Impurity | CS-O-07525 | 224626-08-8 | Enquire |
| 4-Cyclobutyl-L-Proline Methyl Ester Hydrochloride | Impurity | CS-BW-00032 | Not Available | Enquire |
| 4-Cyclopropyl-L-Proline Methyl Ester Hydrochloride | Impurity | CS-BW-00033 | 1296797-07-3 | Enquire |
| 7-Methoxycoumarin-4-acetyl-L-proline | Impurity | CS-T-32339 | 359436-90-1 | Enquire |
| Boc-(R)-alpha-benzyl-proline | Impurity | CS-AC-03977 | 706806-60-2 | Enquire |
| Boc-(S)-alpha-benzyl-proline | Impurity | CS-AC-03852 | 706806-61-3 | Enquire |
| Boc-3,4-dehydro-L-proline | Impurity | CS-T-67633 | 51154-06-4 | Enquire |
| Boc-cis-3-hydroxy-L-proline | Impurity | CS-T-68550 | 186132-96-7 | Enquire |
| cis-4-Hydroxy-D-proline | Impurity | CS-T-56392 | 2584-71-6 | Enquire |
| Cis-4-Mercapto-L-proline hydrochloride | Impurity | CS-AC-07998 | 78854-27-0 | Enquire |
| D-Thioproline | Impurity | CS-T-44136 | 45521-09-3 | Enquire |
| Fmoc-(r,s)-3,4-cis-methanoproline | Impurity | CS-AC-03993 | 1820598-59-1 | Enquire |
| L-Alanyl-L-proline tert-Butyl Ester | Impurity | CS-T-01513 | 29375-30-2 | Enquire |
| L-Proline, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ... | Impurity | CS-EM-02840 | 168263-82-9 | Enquire |
| N-Boc-cis-4-N-Fmoc-amino-L-proline | Impurity | CS-T-67637 | 174148-03-9 | Enquire |
| N-(Benzyloxycarbonyl)-4-hydroxyproline Methyl Ester | Impurity | CS-T-05982 | 64187-48-0 | Enquire |
| N-(tert-Butoxycarbonyl)-(3S)-hydroxy-L-proline methyl ester | Impurity | CS-N-00466 | 184046-78-4 | Enquire |
| N-Benzyl-(S)-proline | Impurity | CS-T-06251 | 31795-93-4 | Enquire |
| N-Boc-cis-3,4-methylene D-Proline | Impurity | CS-T-07618 | 937244-10-5 | Enquire |
| N-Boc-L-trans-4,5-methanoproline Ethyl Ester | Impurity | CS-T-68460 | 214193-10-9 | Enquire |
| N-Methacryloyl-L-proline | Impurity | CS-T-32097 | 51161-88-7 | Enquire |
| O-[(2S)-3,3-Dimethyl-N-benzyl-proline Methyl Ester] S-Methyl... | Impurity | CS-T-53439 | 1219237-13-4 | Enquire |
| O-[(2S)-3,3-Dimethyl-N-boc-proline Methyl Ester] S-Methyl Xa... | Impurity | CS-T-53444 | 1219402-96-6 | Enquire |
| Pidotimod Thioproline dimer impurity | Impurity | CS-O-42606 | 1527463-63-3 | Enquire |
| trans 4-Hydroxy-L-proline -β-Naphthylamide | Impurity | CS-T-28453 | 3326-64-5 | Enquire |
| trans-1-benzoyl-4-phenyl-l-proline | Impurity | CS-O-31683 | 120851-71-0 | Enquire |
| trans-N-tert-Butyloxycarbonyl-4-tosyloxy-L-proline Methyl Es... | Impurity | CS-T-50143 | 88043-21-4 | Enquire |
| Z-cis-D-4-Hydroxyproline | Impurity | CS-T-78168 | 130930-25-5 | Enquire |
Intermediate
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| L-Proline Benzyl Ester Hydrochloride | Intermediate | CS-T-85098 | 16652-71-4 | In Stock |
| L-Proline t-butyl ester | Intermediate | CS-M-47114 | 2812-46-6 | In Stock |
| L-Prolylglycyl-L-proline | Intermediate | CS-O-59100 | 7561-51-5 | Enquire |
| N-Boc-4-Oxo-L-proline | Intermediate | CS-M-57250 | 84348-37-8 | In Stock |
| PNZ-L-Hydroxy Proline | Intermediate | CS-T-28600 | 96034-57-0 | In Stock |
| trans-4-Hydroxy-L-proline | Intermediate | CS-T-28448 | 51-35-4 | In Stock |
Fine Chemicals
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (+)-Z-D-Proline | Fine Chemicals | CS-DA-00241 | 6404-31-5 | Enquire |
| (4S)-4-Phenyl-D-proline ethyl ester | Fine Chemicals | CS-O-51815 | 1820999-06-1 | Enquire |
| 1-[(2R)-3-Mercapto-2-methyl-1-oxopropyl]-D-proline | Fine Chemicals | CS-TB-86919 | 112243-88-6 | In Stock |
| 4-Phenylproline methyl ester | Fine Chemicals | CS-O-51819 | 1466813-84-2 | Enquire |
| Glycyl-L-proline 7-amido-4-methylcoumarin hydrobromide | Fine Chemicals | CS-CE-00752 | 115035-46-6 | In Stock |
| L-Proline | Fine Chemicals | CS-T-40567 | 147-85-3 | In Stock |
| L-Proline tetrazole | Fine Chemicals | CS-P-09174 | 33878-70-5 | Enquire |
| L-Thioproline | Fine Chemicals | CS-O-32009 | 34592-47-7 | In Stock |
| (3-oxopropanoyl)proline | Fine Chemicals | CS-O-37414 | Not Available | Enquire |
| 1-Isopropylproline | Fine Chemicals | CS-M-45556 | 342793-00-4 | Enquire |
| D-Proline tert-Butyl Ester | Fine Chemicals | CS-T-85304 | 90071-62-8 | Enquire |
| L-Alanyl-L-proline | Fine Chemicals | CS-T-01512 | 13485-59-1 | Enquire |
| N2-((S}-1-Corboxy-3 phenylpropyl)-N6- (ethoxy carbonyl)-L-ly... | Fine Chemicals | CS-O-34508 | Not Available | Enquire |
| N-Acetyl-3,4-dehydroproline | Fine Chemicals | CS-ED-01251 | 76945-40-9 | Enquire |
Building Blocks
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| (Fmoc-O-t-butyl-L-4-hydroxyproline | Building Blocks | CS-M-29841 | 122996-47-8 | Enquire |
| 1-L-Prolyl-L-proline Hydrochloride | Building Blocks | CS-ED-42209 | 76932-06-4 | Enquire |
| boc-trans-Hydroxy-L-proline | Building Blocks | CS-T-28484 | 13726-69-7 | In Stock |
| D-Proline | Building Blocks | CS-M-57677 | 344-25-2 | In Stock |
| L-Lysyl-L-proline | Building Blocks | CS-T-57344 | 52766-27-5 | In Stock |
| L-Proline, methyl ester | Building Blocks | CS-O-47363 | 2577-48-2 | Enquire |
| N-Acetyl-L-proline | Building Blocks | CS-O-30988 | 68-95-1 | In Stock |
| N-Phenacetyl-L-proline | Building Blocks | CS-O-56958 | 2752-38-7 | Enquire |
| (((9H-Fluoren-9-yl)methoxy)carbonyl)glycyl-D-proline | Building Blocks | CS-O-52380 | 2171235-45-1 | Enquire |
| ((Benzyloxy)carbonyl)-D-alanyl-D-proline | Building Blocks | CS-O-52377 | 1682648-28-7 | Enquire |
| ((Benzyloxy)carbonyl)-D-alanyl-L-proline | Building Blocks | CS-O-52379 | 22209-78-5 | Enquire |
| ((Benzyloxy)carbonyl)-D-prolyl-D-proline | Building Blocks | CS-O-52373 | 5183-91-5 | Enquire |
| ((Benzyloxy)carbonyl)-D-prolyl-L-proline | Building Blocks | CS-O-52375 | 1221446-62-3 | Enquire |
| ((Benzyloxy)carbonyl)-L-alanyl-D-proline | Building Blocks | CS-O-52378 | 116939-94-7 | Enquire |
| ((Benzyloxy)carbonyl)-L-prolyl-D-proline | Building Blocks | CS-O-52374 | 1867108-30-2 | Enquire |
| (3-(((Benzyloxy)carbonyl)amino)propanoyl)-L-proline | Building Blocks | CS-O-52376 | 61058-47-7 | Enquire |
| (4R)-4-Hydroxy-1-methyl-L-proline | Building Blocks | CS-T-78532 | 4252-82-8 | Enquire |
| (4R)-4-Propyl-L-proline | Building Blocks | CS-O-16130 | 31101-27-6 | Enquire |
| (R)-1-(3-Bromo-2-methyl-1-oxopropyl)-L-proline | Building Blocks | CS-T-49801 | 80629-36-3 | Enquire |
| (trans)-4-Propyl-L-proline Methyl Ester | Building Blocks | CS-T-40809 | 1356354-47-6 | Enquire |
| 1-(1-Oxohexadecyl)-L-proline sodium salt | Building Blocks | CS-M-54946 | 58725-33-0 | Enquire |
| 1-[(2R)-3-Hydroxy-2-methyl-1-oxopropyl]-L-proline | Building Blocks | CS-T-56218 | 613256-52-3 | Enquire |
| 1-[(2S)-3-(Acetylthio)-2-methylpropionyl]-L-proline | Building Blocks | CS-O-32312 | 64838-55-7 | Enquire |
| 1-[1-Deoxy-2,3:4,5-bis-O-(1-methylethylidene)-ß-D-fructopyra... | Building Blocks | CS-T-73403 | 173966-36-4 | Enquire |
| 1-[N2,N6-Bis[(phenylmethoxy)carbonyl]-L-lysyl]-L-proline Phe... | Building Blocks | CS-T-67730 | 145435-28-5 | Enquire |
| 1-ethyl-L-proline | Building Blocks | CS-TB-45312 | 98435-76-8 | Enquire |
| 3,4-Dehydro-L-proline Hydrochloride | Building Blocks | CS-T-73383 | 201469-31-0 | Enquire |
| 3-Allohydroxy-L-proline;cis-3-Hydroxy-L-proline; cis-3-Hydro... | Building Blocks | CS-DV-02096 | 567-35-1 | Enquire |
| Biocytin-L-proline | Building Blocks | CS-T-49113 | 1356931-03-7 | Enquire |
| Biocytin-N-(t-boc)-L-proline | Building Blocks | CS-T-49112 | 1356383-21-5 | Enquire |
| Boc-L-proline methyl ester | Building Blocks | CS-DB-00032 | 59936-29-7 | Enquire |
| cis-4-Hydroxy-L-proline | Building Blocks | CS-T-28447 | 618-27-9 | Enquire |
| cis-4-Hydroxy-L-proline Methyl Ester Hydrochloride | Building Blocks | CS-T-78918 | 40126-30-5 | Enquire |
| Fmoc-L-beta-homoproline | Building Blocks | CS-T-77833 | 193693-60-6 | Enquire |
| N-(tert-Butoxycarbonyl)-L-proline | Building Blocks | CS-T-49551 | 15761-39-4 | Enquire |
| N6-Trifluoroacetyl-L-lysyl-L-proline | Building Blocks | CS-T-88014 | 103300-89-6 | Enquire |
| N-acetyl-4-oxo-L-proline | Building Blocks | CS-O-13059 | 76868-78-5 | Enquire |
| N-Amino-D-proline | Building Blocks | CS-T-03338 | 10139-05-6 | Enquire |
| N-benzyloxycarbonyl-L-alanyl-L-proline | Building Blocks | CS-ED-42210 | 21027-01-0 | Enquire |
| N-Boc-alpha-methyl-l-proline | Building Blocks | CS-DL-00112 | 103336-06-7 | Enquire |
| N-Boc-cis-4-hydroxy-D-proline | Building Blocks | CS-G-00109 | 135042-12-5 | Enquire |
| N-Boc-cis-4-hydroxy-D-proline methyl ester | Building Blocks | CS-DV-03647 | 114676-69-6 | Enquire |
| N-Boc-trans-4-amino-L-proline methyl ester | Building Blocks | CS-AC-04713 | 121148-00-3 | Enquire |
| N-Carbobenzoxy-l-proline tert-butyl ester | Building Blocks | CS-T-70241 | 16881-39-3 | Enquire |
| N-Cbz-cis-4-hydroxy-l-proline methyl ester | Building Blocks | CS-T-70357 | 57653-35-7 | Enquire |
| N-CBZ-Glycyl-L-proline 7-Amido-4-methylcoumarin | Building Blocks | CS-T-68993 | 68542-93-8 | Enquire |
| trans-4-Hydroxy-1-L-phenylalanyl-L-proline | Building Blocks | CS-T-78088 | 90965-82-5 | Enquire |
| trans-4-Methyl-L-proline Hydrochloride | Building Blocks | CS-T-34243 | 365280-18-8 | Enquire |
Nitrosamine
| COMPOUND | CATEGORY | CAT. No. | CAS. No. | STOCK STATUS |
|---|---|---|---|---|
| 1-nitroso-DL-Proline | Nitrosamine | CS-O-49119 | 2571-28-0 | In Stock |
| N-Nitroso D-Hydroxyproline | Nitrosamine | CS-O-58481 | 1932275-09-6 | Enquire |
| N-Nitroso-D-proline (Mixture of Isomers) | Nitrosamine | CS-T-37290 | 42022-03-7 | In Stock |
| N-Nitroso-L-hydroxyproline | Nitrosamine | CS-T-83699 | 30310-80-6 | In Stock |
| N-Nitroso-L-proline | Nitrosamine | CS-T-37289 | 7519-36-0 | In Stock |
| Vildagliptin N-Nitroso-L-Proline Methyl Ester | Nitrosamine | CS-EO-01927 | 35909-01-4 | In Stock |