Nafamostat is a drug used to inhibit blood clotting and treat certain medical conditions. However, during the manufacturing process of nafamostat, impurities may be introduced which can affect the drug's purity, safety, and efficacy. Therefore, it is important to identify, monitor and control these impurities to ensure the quality and safety of the drug. These impurities may include degradation products, residual solvents, and heavy metals, among others.