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Apixaban Related Compounds

Fine Chemicals

COMPOUNDCATEGORYCAT. No.CAS. No.ACTIONS
X Structure - (Z)-ethyl 2-chloro-2-(2-(2-methoxyphenyl)hydrazono)acetate

(Z)-ethyl 2-chloro-2-(2-(2-methoxyphenyl)hydrazono)acetate
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Fine Chemicals CS-O-39250 2228050-22-2
X Structure - {5-hydroxy-6-oxo-1-[4-(2-oxopiperidin-1-yl)phenyl]-1,2,3,6- tetrahydropyridin-4-yl}(oxo)acetic acid

{5-hydroxy-6-oxo-1-[4-(2-oxopiperidin-1-yl)phenyl]-1,2,3,6- ...
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Fine Chemicals CS-O-35516 1609409-54-2
X Structure - 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetic acid

2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetic acid
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Fine Chemicals CS-O-36199 40345-06-0
X Structure - 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
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Fine Chemicals CS-ZH-16546 881386-01-2
X Structure - 5-((4-(3-Carbamoyl-1-(4-methoxyphenyl)-7-oxo-4,5-dihydro-1H-pyrazolo[3,4-c]pyridin-6(7H)-yl)phenyl)amino)pentanoic Acid

5-((4-(3-Carbamoyl-1-(4-methoxyphenyl)-7-oxo-4,5-dihydro-1H-...
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Fine Chemicals CS-TA-86542 2206825-87-6
X Structure - 5-Chloro-N-(4-nitrophenyl)pentanamide

5-Chloro-N-(4-nitrophenyl)pentanamide
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Fine Chemicals CS-ZH-30886 1039914-85-6
X Structure - 6-Chlorohexanoyl chloride

6-Chlorohexanoyl chloride
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Fine Chemicals CS-BX-01042 19347-73-0
X Structure - Ethyl 2-chloro-2-(2-(4-ethoxyphenyl)hydrazono)acetate

Ethyl 2-chloro-2-(2-(4-ethoxyphenyl)hydrazono)acetate
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Fine Chemicals CS-ED-01049 37522-29-5
X Structure - Ethyl -2-chloro-2-[2-(3-methoxyphenyl)hydrazin-1-ylidene]acetate

Ethyl -2-chloro-2-[2-(3-methoxyphenyl)hydrazin-1-ylidene]ace...
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Fine Chemicals CS-ZG-76541 405872-78-8
X Structure - Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate

Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate
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Fine Chemicals CS-O-31948 27143-07-3

Impurity

COMPOUNDCATEGORYCAT. No.CAS. No.ACTIONS
X Structure - (Z)-ethyl 2-(2-(4-methoxyphenyl)hydrazono)-2-(5-morpholino-6-oxo-1-(4-(2-oxopiperidin-1-yl)phenyl)-1,2,3,6-tetrahydropyridin-4-yl)acetate

(Z)-ethyl 2-(2-(4-methoxyphenyl)hydrazono)-2-(5-morpholino-6...
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Impurity CS-O-38830 Not Available
X Structure - 1-(2-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one

1-(2-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
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Impurity CS-O-39465 2444918-46-9
X Structure - 1-(4-Aminophenyl)-3-chloro-5,6-dihydro-2(1H)-pyridinone

1-(4-Aminophenyl)-3-chloro-5,6-dihydro-2(1H)-pyridinone
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Impurity CS-T-96113 1801881-15-1
X Structure - 1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one

1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
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Impurity CS-BX-00878 1267610-26-3
X Structure - 2-Chloro-2-(phenylhydrazono)acetic Acid Ethyl Ester

2-Chloro-2-(phenylhydrazono)acetic Acid Ethyl Ester
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Impurity CS-T-96099 28663-68-5
X Structure - 3-chloro-1-(4-nitrophenyl)-piperidin-2-one

3-chloro-1-(4-nitrophenyl)-piperidin-2-one
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Impurity CS-SN-00168 2512213-45-3
X Structure - 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropy...
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Impurity CS-O-31950 545445-44-1
X Structure - 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)piperidin-2(1H)-one

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)piperidin-2(1H...
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Impurity CS-O-46151 Not Available
X Structure - 4-methoxy-N-(4-methoxyphenyl)-N-nitrosoaniline

4-methoxy-N-(4-methoxyphenyl)-N-nitrosoaniline
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Impurity CS-O-53885 6947-36-0
X Structure - 6-(4-Aminophenyl)-4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxyl

6-(4-Aminophenyl)-4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-o...
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Impurity CS-T-66518 1466571-07-2
X Structure - Apixaban Acid Impurity

Apixaban Acid Impurity
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Impurity CS-O-31952 503614-92-4
X Structure - Apixaban Amino Acid Impurity

Apixaban Amino Acid Impurity
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Impurity CS-EO-00222 2206825-87-6
X Structure - Apixaban Amino Acid Impurity Hydrochloride

Apixaban Amino Acid Impurity Hydrochloride
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Impurity CS-EO-03324 2241139-69-3
X Structure - Apixaban carboxybutylaminophenyl

Apixaban carboxybutylaminophenyl
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Impurity CS-O-51474 2264018-89-3
X Structure - Apixaban cyclohexylmethoxy impurity

Apixaban cyclohexylmethoxy impurity
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Impurity CS-O-52314 Not Available
X Structure - Apixaban Diacid Impurity

Apixaban Diacid Impurity
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Impurity CS-O-51742 ----
X Structure - Apixaban dimer impurity

Apixaban dimer impurity
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Impurity CS-O-33907 1998079-11-0
X Structure - Apixaban Ethoxy Diethylamide impurity

Apixaban Ethoxy Diethylamide impurity
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Impurity CS-O-49146 Not Available
X Structure - Apixaban Hydroxy acid Impurity

Apixaban Hydroxy acid Impurity
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Impurity CS-O-52301 2459302-74-8
X Structure - Apixaban imp Dimer-2

Apixaban imp Dimer-2
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Impurity CS-O-41645 Not Available
X Structure - Apixaban Impurity 12

Apixaban Impurity 12
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Impurity CS-O-33908 1998079-12-1
X Structure - Apixaban Impurity 13 Potassium Salt

Apixaban Impurity 13 Potassium Salt
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Impurity CS-EO-01571 Not Available
X Structure - Apixaban Impurity 14

Apixaban Impurity 14
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Impurity CS-EO-01425 1704504-93-7
X Structure - Apixaban Impurity 17

Apixaban Impurity 17
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Impurity CS-P-07037 1423803-24-0
X Structure - Apixaban Impurity 24

Apixaban Impurity 24
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Impurity CS-EO-01424 1928718-22-2
X Structure - Apixaban Impurity 26

Apixaban Impurity 26
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Impurity CS-EO-00580 1449510-64-8
X Structure - Apixaban Impurity 28

Apixaban Impurity 28
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Impurity CS-O-41129 2208275-54-9
X Structure - Apixaban Impurity 29

Apixaban Impurity 29
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Impurity CS-O-39680 2413365-22-5
X Structure - Apixaban Impurity 3

Apixaban Impurity 3
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Impurity CS-T-95959 1643330-62-4
X Structure - Apixaban Impurity 3

Apixaban Impurity 3
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Impurity CS-EO-00997 Not Available
X Structure - Apixaban Impurity 32

Apixaban Impurity 32
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Impurity CS-EO-00685 1998079-16-5
X Structure - Apixaban Impurity 33

Apixaban Impurity 33
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Impurity CS-EO-00334 1686149-78-9
X Structure - Apixaban Impurity 38

Apixaban Impurity 38
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Impurity CS-EO-02748 1998079-13-2
X Structure - Apixaban Impurity 39

Apixaban Impurity 39
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Impurity CS-EO-02749 1998079-14-3
X Structure - Apixaban Impurity 40

Apixaban Impurity 40
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Impurity CS-P-08545 Not Available
X Structure - Apixaban Impurity 43

Apixaban Impurity 43
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Impurity CS-EO-00686 1998079-15-4
X Structure - Apixaban Impurity 44

Apixaban Impurity 44
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Impurity CS-P-08544 2206825-81-0
X Structure - Apixaban Impurity 51

Apixaban Impurity 51
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Impurity CS-EO-01545 1620494-29-2
X Structure - Apixaban Impurity 52

Apixaban Impurity 52
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Impurity CS-EO-01544 1620494-31-6
X Structure - Apixaban Impurity 78

Apixaban Impurity 78
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Impurity CS-O-56631 1620386-62-0
X Structure - Apixaban Impurity 84

Apixaban Impurity 84
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Impurity CS-EO-02817 2816305-40-3
X Structure - Apixaban Impurity 99

Apixaban Impurity 99
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Impurity CS-O-54494 1801881-16-2
X Structure - Apixaban impurity A

Apixaban impurity A
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Impurity CS-AQ-00214 2098457-92-0
X Structure - Apixaban Impurity C

Apixaban Impurity C
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Impurity CS-EO-00943 1904628-10-9
X Structure - Apixaban impurity E

Apixaban impurity E
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Impurity CS-EO-00940 1609409-53-1
X Structure - Apixaban Intermediate

Apixaban Intermediate
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Impurity CS-O-59639 ----
X Structure - Apixaban Isopropyl Ester Impurity

Apixaban Isopropyl Ester Impurity
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Impurity CS-O-36474 Not Available
X Structure - Apixaban meta methoxy Impurity

Apixaban meta methoxy Impurity
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Impurity CS-O-54495 1801881-18-4
X Structure - Apixaban methyl ester Dimer imp

Apixaban methyl ester Dimer imp
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Impurity CS-O-41644 Not Available
X Structure - Apixaban Methyl Ester Impurity

Apixaban Methyl Ester Impurity
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Impurity CS-O-15286 1074365-84-6
X Structure - Apixaban Open Ring Amide

Apixaban Open Ring Amide
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Impurity CS-AQ-00217 2187409-01-2
X Structure - Apixaban PG Ester-I

Apixaban PG Ester-I
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Impurity CS-O-35352 Not Available
X Structure - Apixaban Related Compound 1

Apixaban Related Compound 1
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Impurity CS-P-00639 4792-57-8
X Structure - Apixaban Related Compound D

Apixaban Related Compound D
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Impurity CS-T-77184 1351611-14-7
X Structure - Apixaban Related Compound F

Apixaban Related Compound F
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Impurity CS-O-32147 536759-91-8
X Structure - Apixaban Related Compound G

Apixaban Related Compound G
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Impurity CS-O-43379 881386-12-5
X Structure - Apixaban Related Compound H

Apixaban Related Compound H
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Impurity CS-P-07038 1421823-20-2
X Structure - Apixaban ring open Diacid and amide impurity

Apixaban ring open Diacid and amide impurity
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Impurity CS-O-54365 ----
X Structure - Desmethoxy Apixaban

Desmethoxy Apixaban
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Impurity CS-EO-00211 1801881-17-3
X Structure - Ethyl (2E)-2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]acetate

Ethyl (2E)-2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]ac...
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Impurity CS-O-44767 1644619-42-0
X Structure - ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazineylidene)acetate

ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazineylidene)ac...
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Impurity CS-ED-01790 473927-63-8
X Structure - Ethyl 2-chloro-2-[2-(2-methoxyphenyl)hydrazin-1-ylidene]acetate

Ethyl 2-chloro-2-[2-(2-methoxyphenyl)hydrazin-1-ylidene]acet...
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Impurity CS-O-46150 85014-68-2
X Structure - Ethyl-2-chloro-2-(2-(4-hydroxy phenyl)hydrazono)acetate

Ethyl-2-chloro-2-(2-(4-hydroxy phenyl)hydrazono)acetate
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Impurity CS-O-46152 Not Available
X Structure - N-(4-methoxyphenyl)nitrous hydrazide

N-(4-methoxyphenyl)nitrous hydrazide
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Impurity CS-O-44916 Not Available
X Structure - O-Desmethyl Apixaban

O-Desmethyl Apixaban
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Impurity CS-T-15230 503612-76-8
X Structure - O-Desmethyl Apixaban Sulfate

O-Desmethyl Apixaban Sulfate
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Impurity CS-T-88771 1118765-14-2

Intermediate

COMPOUNDCATEGORYCAT. No.CAS. No.ACTIONS
X Structure - Apixaban Related Compound 2

Apixaban Related Compound 2
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Intermediate CS-O-10617 536760-29-9

Nitrosamine

COMPOUNDCATEGORYCAT. No.CAS. No.ACTIONS
X Structure - (E)-1-(4-methoxyphenyl)-2-nitrosodiazene

(E)-1-(4-methoxyphenyl)-2-nitrosodiazene
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Nitrosamine CS-O-59136 ----
X Structure - (Z)-ethyl 2-chloro-2-(2-(4-methoxyphenyl)-2-nitrosohydrazono)acetate

(Z)-ethyl 2-chloro-2-(2-(4-methoxyphenyl)-2-nitrosohydrazono...
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Nitrosamine CS-O-43008 Not Available
X Structure - 5-((4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)(nitroso)amino)pentanoic acid

5-((4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl...
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Nitrosamine CS-O-49703 Not Available
X Structure - Apixaban Nitrosoacid impurity

Apixaban Nitrosoacid impurity
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Nitrosamine CS-O-45384 Not Available
X Structure - Apixaban Nitrosoamide impurity

Apixaban Nitrosoamide impurity
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Nitrosamine CS-O-45383 ----
X Structure - Apixaban N-Nitroso Impurity 16

Apixaban N-Nitroso Impurity 16
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Nitrosamine CS-O-50954 Not Available
X Structure - Apixaban N-Nitroso Impurity 3

Apixaban N-Nitroso Impurity 3
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Nitrosamine CS-O-50195 Not Available
X Structure - Apixaban N-Nitroso Related Compound H

Apixaban N-Nitroso Related Compound H
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Nitrosamine CS-O-50196 Not Available
X Structure - Ethyl (E)-2-(2-(4-hydroxyphenyl)-2-nitrosohydrazineylidene)-3-oxobutanoate

Ethyl (E)-2-(2-(4-hydroxyphenyl)-2-nitrosohydrazineylidene)-...
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Nitrosamine CS-O-59137 ----
X Structure - Ethyl (Z)-2-chloro-2-(2-(4-chlorophenyl)-2-nitrosohydrazineylidene)acetate

Ethyl (Z)-2-chloro-2-(2-(4-chlorophenyl)-2-nitrosohydraziney...
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Nitrosamine CS-O-59138 ----
X Structure - N-Nitroso 5-Chloropentanamide Apixaban

N-Nitroso 5-Chloropentanamide Apixaban
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Nitrosamine CS-O-44917 Not Available
X Structure - N-Nitroso Apixaban Amino Acid ethyl ester Impurity

N-Nitroso Apixaban Amino Acid ethyl ester Impurity
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Nitrosamine CS-O-54413 ----
X Structure - N-Nitroso Apixaban diacid impurity

N-Nitroso Apixaban diacid impurity
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Nitrosamine CS-O-53125 ----
X Structure - N-Nitroso Apixaban Diamide Impurity

N-Nitroso Apixaban Diamide Impurity
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Nitrosamine CS-O-48922 Not Available
X Structure - N-Nitroso Apixaban Impurity 73 (Z-isomer)

N-Nitroso Apixaban Impurity 73 (Z-isomer)
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Nitrosamine CS-O-57169 ----

Stable Isotopes

COMPOUNDCATEGORYCAT. No.CAS. No.ACTIONS
X Structure - Apixaban Acid-13C

Apixaban Acid-13C
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Stable Isotopes CS-F-00053 503614-92-4(Unlabelled)
X Structure - Apixaban Acid-13C,D3

Apixaban Acid-13C,D3
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Stable Isotopes CS-F-00176 503614-92-4 (unlabelled)
X Structure - Apixaban PG Ester-I d3

Apixaban PG Ester-I d3
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Stable Isotopes CS-T-103968 1904628-12-1(unlabelled)
X Structure - Apixaban PG Ester-II d3

Apixaban PG Ester-II d3
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Stable Isotopes CS-T-103969 1904628-11-0(unlabelled)

Therapeutic

COMPOUNDCATEGORYCAT. No.CAS. No.ACTIONS
X Structure - 4,5-Dehydro Apixaban

4,5-Dehydro Apixaban
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Therapeutic CS-O-15285 1074549-89-5
X Structure - Apixaban

Apixaban
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Therapeutic CS-O-00932 503612-47-3
X Structure - Apixaban aminophenyl Impurity

Apixaban aminophenyl Impurity
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Therapeutic CS-O-32148 503615-07-4
X Structure - Apixaban Ester Impurity

Apixaban Ester Impurity
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Therapeutic CS-O-15287 503614-91-3
X Structure - Apixaban Impurity B

Apixaban Impurity B
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Therapeutic CS-AQ-00215 1686149-74-5
X Structure - Apixaban-13C,d3

Apixaban-13C,d3
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Therapeutic CS-O-06410 1261393-15-0