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Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Apixaban, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Apixaban impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Apixaban-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.

Apixaban Related Compounds

Stable Isotopes

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Apixaban Acid-13C Stable Isotopes CS-F-00053 503614-92-4(Unlabelled) Enquire
Apixaban Acid-13C,D3 Stable Isotopes CS-F-00176 503614-92-4 (unlabelled) Enquire
Apixaban PG Ester-I d3 Stable Isotopes CS-T-103968 1904628-12-1(unlabelled) Enquire
Apixaban PG Ester-II d3 Stable Isotopes CS-T-103969 1904628-11-0(unlabelled) Enquire
Apixaban-13C,d3 Stable Isotopes CS-O-06410 1261393-15-0 In Stock
Apixaban-d3 Stable Isotopes CS-T-66655 1131996-12-7 In Stock
Apixaban 13C D7 Stable Isotopes CS-O-15737 503612-47-3 (Unlabeled) Enquire


API

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Apixaban API CS-O-00932 503612-47-3 In Stock


Impurity

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
1-(4-Aminophenyl)-3-chloro-5,6-dihydro-2(1H)-pyridinone Impurity CS-T-96113 1801881-15-1 Enquire
1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one Impurity CS-BX-00878 1267610-26-3 In Stock
2-Chloro-2-(phenylhydrazono)acetic Acid Ethyl Ester Impurity CS-T-96099 28663-68-5 Enquire
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropy... Impurity CS-O-31950 545445-44-1 In Stock
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)piperidin-2(1H... Impurity CS-O-46151 Not Available Enquire
4-methoxy-N-(4-methoxyphenyl)-N-nitrosoaniline Impurity CS-O-53885 6947-36-0 In Stock
Apixaban Acid Impurity Impurity CS-O-31952 503614-92-4 In Stock
Apixaban Amino Acid Impurity Impurity CS-EO-00222 2206825-87-6 In Stock
Apixaban Amino Acid Impurity Hydrochloride Impurity CS-EO-03324 2241139-69-3 Enquire
Apixaban aminophenyl Impurity Impurity CS-O-32148 503615-07-4 In Stock
Apixaban carboxybutylaminophenyl Impurity CS-O-51474 2264018-89-3 In Stock
Apixaban Chloro Impurity Impurity CS-O-34152 2029205-64-7 In Stock
Apixaban cyclohexylmethoxy impurity Impurity CS-O-52314 Not Available Enquire
Apixaban Diacid Impurity Impurity CS-O-51742 ---- In Stock
Apixaban Ethoxy Diethylamide impurity Impurity CS-O-49146 Not Available In Stock
Apixaban Hydroxy acid Impurity Impurity CS-O-52301 2459302-74-8 Enquire
Apixaban Impurity 17 Impurity CS-P-07037 1423803-24-0 In Stock
Apixaban Impurity 24 Impurity CS-EO-01424 1928718-22-2 In Stock
Apixaban Impurity 26 Impurity CS-EO-00580 1449510-64-8 In Stock
Apixaban Impurity 3 Impurity CS-T-95959 1643330-62-4 Enquire
Apixaban Impurity 32 Impurity CS-EO-00685 1998079-16-5 Enquire
Apixaban Impurity 38 Impurity CS-EO-02748 1998079-13-2 Enquire
Apixaban Impurity 39 Impurity CS-EO-02749 1998079-14-3 Enquire
Apixaban Impurity 44 Impurity CS-P-08544 2206825-81-0 In Stock
Apixaban Impurity 78 Impurity CS-O-56631 1620386-62-0 Enquire
Apixaban Impurity 84 Impurity CS-EO-02817 2816305-40-3 Enquire
Apixaban Impurity 99 Impurity CS-O-54494 1801881-16-2 Enquire
Apixaban impurity A Impurity CS-AQ-00214 2098457-92-0 In Stock
Apixaban Impurity B Impurity CS-AQ-00215 1686149-74-5 In Stock
Apixaban Impurity C Impurity CS-EO-00943 1904628-10-9 In Stock
Apixaban impurity E Impurity CS-EO-00940 1609409-53-1 Enquire
Apixaban Intermediate Impurity CS-O-59639 ---- Enquire
Apixaban Isopropyl Ester Impurity Impurity CS-O-36474 Not Available In Stock
Apixaban meta methoxy Impurity Impurity CS-O-54495 1801881-18-4 Enquire
Apixaban Methyl Ester Impurity Impurity CS-O-15286 1074365-84-6 In Stock
Apixaban Open Ring Amide Impurity CS-AQ-00217 2187409-01-2 In Stock
Apixaban Related Compound 1 Impurity CS-P-00639 4792-57-8 In Stock
Apixaban Related Compound D Impurity CS-T-77184 1351611-14-7 In Stock
Apixaban Related Compound F Impurity CS-O-32147 536759-91-8 In Stock
Apixaban Related Compound G Impurity CS-O-43379 881386-12-5 In Stock
Apixaban Related Compound H Impurity CS-P-07038 1421823-20-2 In Stock
Apixaban ring open Diacid and amide impurity Impurity CS-O-54365 ---- Enquire
Desmethoxy Apixaban Impurity CS-EO-00211 1801881-17-3 In Stock
Ethyl (2E)-2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]ac... Impurity CS-O-44767 1644619-42-0 Enquire
ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazineylidene)ac... Impurity CS-ED-01790 473927-63-8 In Stock
Ethyl 2-chloro-2-[2-(2-methoxyphenyl)hydrazin-1-ylidene]acet... Impurity CS-O-46150 85014-68-2 Enquire
Ethyl-2-chloro-2-(2-(4-hydroxy phenyl)hydrazono)acetate Impurity CS-O-46152 Not Available Enquire
Hydroxy O-Demethyl Apixaban Impurity CS-EO-02248 2204368-56-7 Enquire
N-(4-methoxyphenyl)nitrous hydrazide Impurity CS-O-44916 Not Available Enquire
O-Desmethyl Apixaban Impurity CS-T-15230 503612-76-8 In Stock
(Z)-ethyl 2-(2-(4-methoxyphenyl)hydrazono)-2-(5-morpholino-6... Impurity CS-O-38830 Not Available Enquire
1-(2-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one Impurity CS-O-39465 2444918-46-9 Enquire
3-chloro-1-(4-nitrophenyl)-piperidin-2-one Impurity CS-SN-00168 2512213-45-3 Enquire
3-morpholino-1-(4-nitrophenyl)pyridin-2(1H)-one Impurity CS-O-35634 2818923-97-4 Enquire
4,5-Dehydro Apixaban Impurity CS-O-15285 1074549-89-5 Enquire
6-(4-Aminophenyl)-4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-o... Impurity CS-T-66518 1466571-07-2 Enquire
Apixaban dimer impurity Impurity CS-O-33907 1998079-11-0 Enquire
Apixaban imp Dimer-2 Impurity CS-O-41645 Not Available Enquire
Apixaban Impurity - (2 H2O) Impurity CS-O-40429 898235-61-5 Enquire
Apixaban Impurity - (3/2 H2O) Impurity CS-O-40428 1623070-09-6 Enquire
Apixaban Impurity 12 Impurity CS-O-33908 1998079-12-1 Enquire
Apixaban Impurity 13 Potassium Salt Impurity CS-EO-01571 Not Available Enquire
Apixaban Impurity 14 Impurity CS-EO-01425 1704504-93-7 Enquire
Apixaban Impurity 16 Impurity CS-EO-01572 2203740-09-2 Enquire
Apixaban Impurity 27 Impurity CS-EO-00579 2133292-60-9 Enquire
Apixaban Impurity 28 Impurity CS-O-41129 2208275-54-9 Enquire
Apixaban Impurity 29 Impurity CS-O-39680 2413365-22-5 Enquire
Apixaban Impurity 3 Impurity CS-EO-00997 Not Available Enquire
Apixaban Impurity 33 Impurity CS-EO-00334 1686149-78-9 Enquire
Apixaban Impurity 34 Impurity CS-EO-01012 2098457-93-1 Enquire
Apixaban Impurity 40 Impurity CS-P-08545 Not Available Enquire
Apixaban Impurity 43 Impurity CS-EO-00686 1998079-15-4 Enquire
Apixaban Impurity 5 Impurity CS-EO-00998 Not Available Enquire
Apixaban Impurity 51 Impurity CS-EO-01545 1620494-29-2 Enquire
Apixaban Impurity 52 Impurity CS-EO-01544 1620494-31-6 Enquire
Apixaban methyl ester Dimer imp Impurity CS-O-41644 Not Available Enquire
Apixaban PG Ester-I Impurity CS-O-35352 Not Available Enquire
Apixaban PG Ester-II Impurity CS-O-35353 Not Available Enquire
Apixaban Related Compound 5 Impurity CS-EO-00335 2219376-48-2 Enquire
AXN-III Impurity CS-T-94078 473927-64-9 Enquire
Methyl 5-((4-(3-Carbamoyl-1-(4-methoxyphenyl)-7-oxo-4,5-dihy... Impurity CS-O-39508 Not Available Enquire
O-Desmethyl Apixaban Sulfate Impurity CS-T-88771 1118765-14-2 Enquire


Intermediate

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Apixaban Related Compound 2 Intermediate CS-O-10617 536760-29-9 In Stock
Methyl 5-bromovalerate Intermediate CS-T-81382 5454-83-1 In Stock
N-[(5-Bromo-2-thienyl)methyl]-2-[(2-chloroacetyl)amino]-N-me... Intermediate CS-O-53128 1904028-10-9 Enquire


Fine Chemicals

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(Z)-ethyl 2-chloro-2-(2-(2-methoxyphenyl)hydrazono)acetate Fine Chemicals CS-O-39250 2228050-22-2 Enquire
5-Bromovaleric Acid Fine Chemicals CS-T-08691 2067-33-6 In Stock
{5-hydroxy-6-oxo-1-[4-(2-oxopiperidin-1-yl)phenyl]-1,2,3,6- ... Fine Chemicals CS-O-35516 1609409-54-2 Enquire
2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetic acid Fine Chemicals CS-O-36199 40345-06-0 Enquire
3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Fine Chemicals CS-ZH-16546 881386-01-2 Enquire
5-((4-(3-Carbamoyl-1-(4-methoxyphenyl)-7-oxo-4,5-dihydro-1H-... Fine Chemicals CS-TA-86542 2206825-87-6 Enquire
5-Chloro-N-(4-nitrophenyl)pentanamide Fine Chemicals CS-ZH-30886 1039914-85-6 Enquire
6-Chlorohexanoyl chloride Fine Chemicals CS-BX-01042 19347-73-0 Enquire
Ethyl 2-chloro-2-(2-(4-ethoxyphenyl)hydrazono)acetate Fine Chemicals CS-ED-01049 37522-29-5 Enquire
Ethyl -2-chloro-2-[2-(3-methoxyphenyl)hydrazin-1-ylidene]ace... Fine Chemicals CS-ZG-76541 405872-78-8 Enquire
Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Fine Chemicals CS-O-31948 27143-07-3 Enquire


Nitrosamine

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(E)-1-(4-methoxyphenyl)-2-nitrosodiazene Nitrosamine CS-O-59136 ---- Enquire
(Z)-ethyl 2-chloro-2-(2-(4-methoxyphenyl)-2-nitrosohydrazono... Nitrosamine CS-O-43008 Not Available Enquire
5-((4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl... Nitrosamine CS-O-49703 Not Available Enquire
Apixaban Nitrosoacid impurity Nitrosamine CS-O-45384 Not Available Enquire
Apixaban Nitrosoamide impurity Nitrosamine CS-O-45383 ---- Enquire
Apixaban N-Nitroso Impurity 16 Nitrosamine CS-O-50954 Not Available Enquire
Apixaban N-Nitroso Impurity 3 Nitrosamine CS-O-50195 Not Available Enquire
Apixaban N-Nitroso Related Compound H Nitrosamine CS-O-50196 Not Available Enquire
Ethyl (E)-2-(2-(4-hydroxyphenyl)-2-nitrosohydrazineylidene)-... Nitrosamine CS-O-59137 ---- Enquire
Ethyl (Z)-2-chloro-2-(2-(4-chlorophenyl)-2-nitrosohydraziney... Nitrosamine CS-O-59138 ---- Enquire
N-Nitroso 5-Chloropentanamide Apixaban Nitrosamine CS-O-44917 Not Available Enquire
N-Nitroso Apixaban Amino Acid ethyl ester Impurity Nitrosamine CS-O-54413 ---- Enquire
N-Nitroso Apixaban diacid impurity Nitrosamine CS-O-53125 ---- Enquire
N-Nitroso Apixaban Diamide Impurity Nitrosamine CS-O-48922 Not Available Enquire
N-Nitroso Apixaban Impurity 73 (Z-isomer) Nitrosamine CS-O-57169 ---- Enquire


Therapeutic

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Apixaban Ester Impurity Therapeutic CS-O-15287 503614-91-3 In Stock